Have people experienced overwhelming exhaustion on high dose venlafaxine, and a feeling of being a bit detached from reality, also, still some suicidal feelings. But how do I know if the venlafaxene is actually making me worse. When I feel at my worst, it is due to the sheer exhaustion, which leads me to feel useless/worthless and generally yuk. I feel sure if I got rid of this "drugged up" feeling I would feel so much better, but don't know what to do or how I can deceide if this is the right medication for me.