Mitchy - I suggest you try some other brands as I have heard of lots of people finding their stomach rejects high5. I use Torq products, which are a bit pricier than some other brands but they have less artificial crap and I find them very digestible. They are not overly sweet either.
With regards to the nutrition whist exercising, I am not a marathon runner so I don't know if there is anything specific to that as a discipline, but I do cycle on a weekly basis for 3-4 hours at a fairly high intensity.
What I have leant from various experts in sport nutrition is that it is better to fuel your long-distance events, even if losing weight is one of your goals. You simply cannot sustain a high level of intensity for more than 90 mins or so without taking on fuel. You will be unable to work as hard, and so you won't be working at the same fat-burning intensity. You will take longer to recover if you don't fuel as you go along, so if you are training several times a week, you will again be unable to work at as high an intensity on each subsequent workout.
Your body takes quite some time to break down fat to use as fuel, and it will not be able to do so in meaningful amounts whilst you are exercising. It certainly can't do so at a sufficient rate to fuel intense exercise. The 'burning' of body fat happens in the recovery period whilst you are still in a calorie deficit from your exercise.
If you are aiming for weight loss at the same time as doing a very demanding sport, you are much better off aiming for a slow and steady loss than anything dramatic. You might think "excellent, I have burned 1,500 calories today, I will lose a shed load of fat" but if you do that several times a week you will end up seriously weakening your body and making yourself unable to train properly, if at all. You are better off aiming for a deficit of no more than maybe 500 calories (inexact figure, I might correct this when I find my book that I seem to have mislaid) per session, so you can keep working hard, recovering well, and training hard again the next session.