@PetraRabbit
babbaloushka
I appreciate your calm post. So many replies in favour of mass vaccination are hysterical and emotion driven.
I think the problem is that the questions I have are ones noone can answer without time travel!
They are: What will the long term effects of these vaccines be? I'm not looking for "all the evidence suggests" or "it follows that..." I'm only really going to be satisfied with the passage of time actually confirming safety over the next five to ten years. Even the best scientists get surprises sometimes.
My other question is whether any of the other vaccines will have their own 'Astra Zeneca moment' as more data becomes available? The blood clot issue was not predicted so it's hard to reassure me another issue is impossible.
That's really the essence of why most who are not keen will be unpersuadable.
Good and valid questions!
The only long term effect a vaccine has is storing the response of your own immune system. Much like when you have a cold, your body makes antibodies to attack the pathogen, and it remembers the antibodies so that next time that pathogen is detected, the immune response happens much more quickly. The constituents of the vaccine (the bits that are injected) are broken down and ejected within a few days, the only lasting effect is your body's immune response.
This is also why people feel side effects; it's not the actual vaccine that makes you feel feverish or achy, but rather the work of your immune system against what it perceives as a viral infection. In an unfortunate way, the side effects are confirmation that your immune system is doing its job, creating antibodies, raising body temperate and working overtime to "kill" the virus.
The issue with AZ clots, as you said, was unpredictable, and even though the instance was comparatively very, very small, it is still a valid concern. The most reassuring advice I can offer is that given the millions of patients receiving the different vaccines, there is an awful, awful lot of data available, far more than we would ever hope for most trials, which allows problems to be identified and dealt with promptly.
In the scale of pharmaceuticals, not even half the drugs you are likely to take (antibiotics, painkillers, steroids) have the same trial sample size, so the risk mitigation of these vaccines is vastly superior to others. No drug is taken without risk, nor any action, really, so I think sometimes putting the risk into perspective is very useful and by comparing it to things you would take without hesitation, like paracetamol, might help alleviate these concerns?
A final point would be that the risk of getting a blood clot from COVID is ten times higher than that of the 79 in 20 million from the AZ vaccine. My company has had an unprecedented demand for child dosages of the drugs used to treat blood clots, and friends on frontline wards have reported seeing more children than ever suffering blood clots secondary to a COVID infection.
Any more questions, please ask! I hope that helps a bit.