In a French newspaper yesterday, there was an article reporting a research paper drawing the hypothesis that the thrombosis events are caused by an abnormal activation of Neutrophil extracellular traps (NET) when vaccine hits a vein instead of muscle tissue.
The paper is in French
ducotedelascience.org/evenements-thrombotiques-apres-le-vaccin-astrazeneca-et-si-cetait-lie-a-une-reponse-immunitaire-discordante/ but you can use google translate to translate it into French. I have done so for the relevant parts and pasted them here
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One of the hypotheses that may explain the occurrence of thrombosis by abnormal activation of NET, following the vaccine injection, is the accidental injection of the vaccine into a vein within the deltoid. The adenoviruses would then be injected directly into the blood, which would trigger an innate and adaptive immune response, the activation of neutrophils and the release of NET. Then the formation of thrombi would define the severity of the thromboses.
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"Intravenous passage: a possible hypothesis, according to the literature?
The adenovirus like many other viruses (retroviruses, lentiviruses, AAV) is widely used in research as a vector either to study certain genes or to deliver them to cells, in vitro or in vivo [14]. In the latter case, the injection of the viruses into mouse models has given rise to numerous publications concerning the pharmacokinetics / pharmacodynamics of these viruses depending on the routes of administration. A recent publication takes stock of the immune response induced by intravenous injection of adenovirus in mice: it shows that adenovirus administered by IV disappears very quickly from the bloodstream and is undetectable after 30 minutes [14].
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"This does not correspond to its elimination but to its trapping . When it comes to large amounts of viral particles, this intravenous administration can be lethal in mice but also in non-human primates [15].
In fact, if the quantity of virus is too large, the different capture mechanisms by the innate immune system can cause hepatic capture and an “inflammatory storm” with cytokine shock, activation of the coagulation cascade, likely to lead to consumer thrombocytopenia, DIC, and multiorgan disease that can endanger or kill mice [14]."