Regulators warning over possible allergic reaction to Pfizer jab if you have significant allergies

[CrunchyCarrot]

UK regulators warn people with history of 'significant' allergic reactions not to have Pfizer/BioNTech jab

Saw this flash up on the news just now.

news.sky.com/story/covid-19-vaccine-uk-regulators-warn-people-with-history-of-significant-allergic-reactions-not-to-have-pfizer-biontech-jab-12155916

Professor Stephen Powis, national medical director for the NHS in England, said: "As is common with new vaccines the MHRA have advised on a precautionary basis that people with a significant history of allergic reactions do not receive this vaccination after two people with a history of significant allergic reactions responded adversely yesterday. Both are recovering well."

Something to consider if you do have significant allergies.

Dsis is so low down on list I guess this all be ironed out by then. Must be alarming for elderly with allergies though so they need to sort.

I pay for a flu jab from a pharmacy each year and I'm always asked about allergies (particularly egg). I wonder those who aren't asked are getting it from their GP?

whereas this development wouldn't put me off having the vaccine if offered, I find it rather worrying that this issue was just picked up in the first day rather than during the trials.

@Frazzled2207

whereas this development wouldn't put me off having the vaccine if offered, I find it rather worrying that this issue was just picked up in the first day rather than during the trials.

Those with severe adverse / allergic reactions were excluded from participating in the trial.

Here’s a full list of those who were excluded from taking part in the Pfizer trial, if anyone is interested.

Exclusion Criteria

• Other medical or psychiatric condition including recent (within the past year) or active suicidal ideation/behavior or laboratory abnormality that may increase the risk of study participation or, in the investigator's judgment, make the participant inappropriate for the study.
• History of severe adverse reaction associated with a vaccine and/or severe allergic reaction (eg, anaphylaxis) to any component of the study intervention(s).
• Receipt of medications intended to prevent COVID 19.
• Previous clinical (based on COVID-19 symptoms/signs alone, if a SARS-CoV-2 NAAT result was not available) or microbiological (based on COVID-19 symptoms/signs and a positive SARS-CoV-2 NAAT result) diagnosis of COVID 19
• Immunocompromised individuals with known or suspected immunodeficiency, as determined by history and/or laboratory/physical examination.
• Bleeding diathesis or condition associated with prolonged bleeding that would, in the opinion of the investigator, contraindicate intramuscular injection.
• Women who are pregnant or breastfeeding.
• Previous vaccination with any coronavirus vaccine.
• Individuals who receive treatment with immunosuppressive therapy, including cytotoxic agents or systemic corticosteroids, eg, for cancer or an autoimmune disease, or planned receipt throughout the study.

Receipt of blood/plasma products or immunoglobulin, from 60 days before study intervention administration or planned receipt throughout the study.

• Participation in other studies involving study intervention within 28 days prior to study entry and/or during study participation.
• Previous participation in other studies involving study intervention containing lipid nanoparticles.
• Investigator site staff or Pfizer employees directly involved in the conduct of the study, site staff otherwise supervised by the investigator, and their respective family members.

If you intentionally exclude a group from trials then it doesn’t make sense to allow that group to be among the first wave injected. That might go for immunocompromised people who weren’t part of the trials either.

We are asking about allergies before vaccinating. This is what should be happening. Unless the individuals lied and said they don't have allergies
Maybe they didn't know or didn't understand? I don't have any allergies. Two years ago I had a bad reaction to the flu jab (which previously I had had without any problems). I've been advised not to have it anymore so not sure where that leaves me with this vaccine.

What symptoms are the bad reaction I wonder?

@Gobbledygook20

What symptoms are the bad reaction I wonder?

Guardian mentioned they had an anaphylactoid reaction

It's normal that people allergic to any of the components were obviously excluded from the trial and people who had had adverse reactions to other vaccines

History of severe adverse reaction associated with a vaccine and/or severe allergic reaction (eg, anaphylaxis) to any component of the study intervention(s).

What's different here is that they're now saying that anyone with a history of any serious allergy at all shouldn't have this one.

Following

@OpheliasCrayon

I hope you can find a solution for the pain. It must be awful

I think it will make a lot of people even more cautious of the new vaccine, just a day in and there are problems...

@Circumlocutious

I'm guessing none of the volunteers in the trial had any severe allegories?

It does seem like the kind of thing that is predictable shouldn't have been flagged up after administration of the vaccine to the population...

Apparently one person in the trial had a severe allergic reaction. I can’t remember where I read that, but I think it was today, possibly on the BBC website

Thank you for the heads up @CrunchyCarrot

Guardian mentioned they had an anaphylactoid reaction

Well yeah.. that is a severe reaction. Bloody hell.

Not the same as anaphylaxis though.

I think anaphylactoid comes with first exposure then with a future exposure they’d be a risk of anaphylactic reaction - is that right? Maybe someone more scientific can confirm .

According to a scientific paper I just looked at:

Anaphylactoid reactions are defined as those reactions that produce the same clinical picture with anaphylaxis but are not IgE mediated, occur through a direct nonimmune-mediated release of mediators from mast cells and/or basophils or result from direct complement activation.

www.ncbi.nlm.nih.gov/pmc/articles/PMC3209676/

This was predictable surely?? Lotsxofvpeople havexreactions to vaccines and medication.
I suspect more than 2vpeople somewhere on thecworld will have had a reaction today to another vaccineclike Typhoid or MMR.

I had a reaction to my Hep A in October.

I'm sadly not in a category to get vaccinated anytime soon but would like to do do, however, I've had increasing allergies the last 5 years and even anaphylactic shock to penicillin at the age of 44 after having had lots of times previously throughout my life, so will need to be careful.

I hope the anti vaxers don't jump on this and make it more of a drama than it actually is in reality.

When you're testing a vaccine or any medication you can't purposely test it on people who might have a problem with it. I mean you don't purposely test pregnant women, people on every combination of medication, people with heart conditions, people in comas, terminal patients and so on.

So all you can do is use it and look for unusual reactions.

Anaphylactic shock kills a lot of people.

First few hours and they have 2 people reacting. How many doses were administered yesterday? 1000 maybe?

Very shoddy behaviour and bullish as usual of the government to push it through to be first, without ensuring the safety of the public.

Bunnyboiler, why do call anyone who has any concerns an anti Vaxer? Everyone is entitled to their own options and concerns whatever they may be.
There certainly seems to be a lot of unpleasant people around now using name calling.

I am an allergy sufferer and can get most vaccinations.

I’m trying hard to find a comprehensive ingredient list for any of the versions of the Covid vaccine and failing. I’d really like to see if my known allergens are on the list. I’m surprisingly upset that I might not be able to get this shot. I know part of my upset is I’m currently dealing with an burn injury that has been very hard for the doctors to treat because I’m allergic to at least one inactive ingredient in all the standard treatments. When you have a decently bad burn you don’t want the doctor to settle on having you use the allergen free tube of aloe you special ordered in case you got a sunburn on holiday. My allergies aren’t even that esoteric, but companies keep using these ingredients without concern for people like us.

My brother has no allergies that we know of but went into anaphylactic shock after whooping cough vaccine many years ago, he’s not had a vaccine since.

I’d imagine this will impact how they were intending to roll out. Sports Halls etc by the 1000? Still sensible? They’ll need waiting time post each injection to assess possible reactions and won’t it mean that mass vaccination will need to be amended? I would hope so. I’m sure the two adverse reactions in hospital yesterday were swiftly seen to but would the same be true in a pop up mass vaccination hub?

There isn't much the regulators can do about a vaccine that has ingredients that some people will be allergic to, though, whether it's approved sooner or later. That's always the case with vaccines. It's not something they won't have predicted to some extent. But awful for the people who won't be able to have it.