Science. Interesting study to genetics. Could this explain something?

[Xtinalee]

If you scroll down to the paragraph starting ‘We found studies...’ in the link... and I looked up the b 4601 gene and it said:
Turns out the B*4601 is the most common HLA-B allele that does not have an origin within Africa, and estimated 400 million people in Eastern Asia carry a B46 allele.

. Our analysis predicted that one allele, called B46:01, is particularly bad with regards to both SARS-CoV-2 and SARS-CoV. Sure enough, previous studies showed that people with this allele tended to have more severe SARS infections and higher viral loads than people with other versions of the HLA gene.

theconversation.com/amp/your-genes-could-determine-whether-the-coronavirus-puts-you-in-the-hospital-and-were-starting-to-unravel-which-ones-matter-137145?__twitter_impression=true

Thoughts?

I think it's interesting, especially as there seems to be a number of families where more than one person has died or been severely ill.

There's already been a large study involving twins who've caught COVID-19. They found that identical twins tended to similar symptoms/severity, whereas there was more variance for non-identical twins - suggesting that genetics does play a role.

Interesting.

It's thought that China were studying coronaviruses not for nefarious purposes, but for self defence (they believed they are more susceptible and wanted to be able to counter an outbreak).

It sounds interesting, but as with any scientific studies, I’d be waiting for a peer-reviewed publication of data..

It does sound like a good reason there are so many bame deaths, but many on mumsnet are so far down the vitamin d aspect that you wont get very far with this.

I've also raised that a lot of covid deaths have been due to the blood clotting and blood clots being found on the lungs rather than pneumonia when they do autopsies. Some people are genetically susceptible to blood clotting, (factor 2 and factor 5) and this is also something prevalent in bame people.

Once they crack the genetics they can really say for certain who is high risk. For example the young and healthy who end up on ventilators and no explanation as to why.😞 they’re not all obese either.

It is useful to know who is at higher risk - but mainly to shield them, as we can't change genetics

Vitamin D is being investigated because it may help avoid the most severe symptoms

Similarly, aspirin may help - BUT regularly taking aspirin can have side effects, which can be serious for a small minority, e.g.

"BMJ: Aspirin, like all other drugs, is a poison"

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1118944/

whereas there are almost no cases of people suffering serious problems from even Vitamin D OVERdoses,
let alone the recommended doses

Yes bigchoc, aspirin can be taken and there are heated discussions both sides of this, ie take it or not take it. What I'm surprised about is that they dont seem to add people to the shielding list who are susceptible to clots. The list mentions sickle cell disease but not factor 2 or 5.

Also read Quercetin And zinc prevents and subsides symptoms . Does anyone know the characteristics of the younger people ending up in icu ?

I agree, tabby the omission of that group is surprising in the light of patient data
Maybe it depends on severity - they are presumably at least classed as "clinically vulnerable"

This doctor uses quercetin and zinc

I watched that last night. He is so informative!!!

Found this also . If anyone can explain or elaborate is appreciate it

Local icu patients have been mainly Asian despite not being in the majority locally. Icu now has 6 Covid patients, 4 of whom are Asian. There is a higher risk I believe, because of the multigenerational households and many members needing to carry on working, so this may be a local risk factor, but it's very interesting research is supporting the BAME risk factor.

www.washingtonpost.com/health/2020/04/24/strokes-coronavirus-young-patients/

Not sure if this link will work but it shows more strokes (essentially blood clots) due to covid.

Ace is an antigen converting enzyme

Yeah I’ve read that too and told my dr my worries when he rang an hour ago and his response was ‘you’re 32 and female and I’ll keep telling you that’ so no matter what I tell my doctors they aren’t taking me seriously and it is frustrating.

Paniquer it isn’t. It’s angiotensin converting enzyme. Similar word, easily confused in the circumstances

www.bbc.co.uk/news/health-52662065

Here's another one about blood clots. They are now saying a third of patients are getting them. Lots of people are genetically susceptible to clotting too.

I’m confused about the cytokine storm aspect. Some say it’s vitamin d deficiency that causes it but some say it’s the immune system being too strong ??! Can anyone shed any light onto this?

I have an autoimmune disorder that means I am at increased risk of clots. I have had no advice telling me I am at raised risk.

From covid I mean. Also have a history of extreme inflammatory responses. I am hoping to speak to a Dr soon just to check there is nothing I should know about this with regard to covid.

There are thousands of people at increased risk to clots. They havent been added to the shielding list or been told they are vulnerable, although I suspect most people with these gene mutations will suspect they are.

There are also genetic changes related to Vitamin D as well...interesting
(I mean low or high levels) VDR Vitamin D receptor genes..

www.nhs.uk/news/genetics-and-stem-cells/genetic-effects-of-vitamin-d-studied/

I’m confused about the cytokine storm aspect. Some say it’s vitamin d deficiency that causes it but some say it’s the immune system being too strong ??! Can anyone shed any light onto this?

A cytokine storm is when the immune system over-reacts. Obviously only a strong immune system is capable of that, but that still doesn't mean it's "correct" behaviour (much like auto-immune diseases). There's a theory that adequate levels of vitamin D helps your immune system launch an appropriate response, rather than an overly strong one.