Science. Interesting study to genetics. Could this explain something?

[Xtinalee]

If you scroll down to the paragraph starting ‘We found studies...’ in the link... and I looked up the b 4601 gene and it said:
Turns out the B*4601 is the most common HLA-B allele that does not have an origin within Africa, and estimated 400 million people in Eastern Asia carry a B46 allele.

. Our analysis predicted that one allele, called B46:01, is particularly bad with regards to both SARS-CoV-2 and SARS-CoV. Sure enough, previous studies showed that people with this allele tended to have more severe SARS infections and higher viral loads than people with other versions of the HLA gene.

theconversation.com/amp/your-genes-could-determine-whether-the-coronavirus-puts-you-in-the-hospital-and-were-starting-to-unravel-which-ones-matter-137145?__twitter_impression=true

Thoughts?

www.scientificamerican.com/article/how-blood-sugar-can-trigger-a-deadly-immune-response-in-the-flu-and-possibly-covid-191/

@PowerslidePanda It just doesn’t make sense to me that someone who eats a perfectly healthy diet with fruit vegetables etc could suffer an inflammatory response ?

What do you mean @Xtinalee?

I read that young and healthy are getting cytokine storms from an immune response that is too strong. If your immune system is strong then how can that be? It just doesn’t make sense .

My understanding is that the cytokines storm is an over reaction- like autoimmune diseases cause self harm. There’s strong and well regulated and too strong and in a panic!

So how do you know what response you’re likely to have?

@PowerslidePanda It just doesn’t make sense to me that someone who eats a perfectly healthy diet with fruit vegetables etc could suffer an inflammatory response ?

Bad foods do trigger inflammation, but so does the immune system (everyone's immune system, regardless of how healthily they eat). Think about when you injure yourself and it goes red and swollen for a bit - that's inflammation, courtesy of your immune system. Inflammation itself isn't a bad thing, but your body being in a permanent state of inflammation is bad.

As for the cytokine storm - think of the virus as invader in your body, and your immune system as an arsenal of weapons. If you have a weak immune system, all you get is a baseball bat. If you have a strong immune system, you have a baseball bat, a pistol and a grenade. The grenade will do a great job of attacking the invader, but it'll also damage everything else. Vitamin D says to your body, "Stop - you want to use the pistol instead!"

I don't think you can reliably predict what response someone will have. To a large extent it's out of your control.

If a heathy diet with fruit and vegetables prevented the immune system going inot inflammatory overdrive that would have solved an immense number of problems years ago!

This is very interesting to me. I have factor V leiden
I had multiple PE tiny aparently so Dr said in the being of March no reason last clot was 23yrs ago after taking combined pill.
Had what could be now classes as mild covid symptoms in February temp, cough fatigue.
Am following with interest.

Metabolic issues seem to play a big part from the research I’ve done. There are a lot of interesting videos from a Dr Or scientist called Ivor that talks about the cytokine storm. Athletes seem to have metabolic issues. This could possibly explain why fit and healthy people experience this. I’m no expert I’ve just done a lot of research because I’m terrified

@PowerslidePanda so why aren’t doctors administering vitamin D instead of C. And how do you know if your immune system is too strong

You sound very anxious, can you explain why you think you would become very unwell if you were to catch covid ? How do you know you haven't already had it ?

@PowerslidePanda so why aren’t doctors administering vitamin D instead of C. And how do you know if your immune system is too strong

In many countries, they are. Lots have advised their citizens to increase their vitamin D levels, as there's evidence emerging of a correlation between vitamin D deficiency and having a more severe case of COVID. In some places, they're also studying whether it's beneficial to inject high doses of vitamin D into patients who are already seriously ill.

Unfortunately, as a PP said, I don't think it's possible to predict how your own immune system will respond.

Zzz has your gp told you to shield?

I am extremely anxious. I have eczema And allergies which is an over reaction in the immune system. Read that the virus activates mast cells in food and drug allergies, which creates an over inflammatory response. Also when I get a virus or even a cold I know about it and have to take time off work. I had some kind of virus or flu in December and I was so ill I had such a high fever. Also had time off work August September October due to being ill. Family had pneumonia in the past. I’m just so scared , when I get ill I know about it so why would this be any different? 😞

Were you hospitalised on any of the occasions you were unwell last year or did you just take time off work and took to your bed feeling really grotty ? but your body fought off whatever virus you had and you recovered ?

No I’ve never been hospitalised but should have called the doctor with my fever in December I felt so dizzy like I was going to pass out and was sick a lot of times. Even the gym goers are getting hospitalised with this. It’s bizarre and the unknown . I do believe viral load plays a big part which is why kids should not be going back to school . My main concern is my immune response.

Your immune response has worked rather well for you, you haven't needed hospital treatment and you have recovered from a variety of viruses. You also can not be absolutely sure that you haven't had Covid already can you ?
Sress/anxiety have a negative impact on your immune system, can you think of any ways to reduce that ?

@frumpety This virus is another species. The cytokine storms target young and healthy as they did in flu 😔

@frumpety also any would I be symptomatic to colds and asymptomatic to covid , doesn’t make sense

@Xtinalee

Everyone bar the very youngest has been symptomatic with colds, and yet many have been asymptomatic with the initial infection at least of covid. So clearly the two things are not mutually exclusive.

On the one hand you are saying you have recovered from other things but covid is different so why would recover from that, and then also saying that other things have caused you symptoms so why would you respond any differently to covid. As you know, it's fear talking.

It's a complex and highly specialised field. It is sensible to try and educate ourselves but there is a danger, well a certainty really, of picking up bits of information without being able to put them in context. Experts will be studying these issues and reviewing each other's findings. If they feel they have insight that leads to practical advice for preventing or treating covid 19, that will become widely known.

Ps. You don't know what you may have had asymptomatically in the past either.

When I’m ill I know about it. The slightest cold puts me in bed. 😞 changed my diet and taking vit c and D and not deficient in D as did a test but I know someone who had mild symptoms who has issues and is deficient in D and obese so no one is safe it’s bizarre and scary