Would you be one of the 500? Vaccine

[RigaBalsam]

Human trials are to start this week. I am
thankful to these people.

I don't know if I could myself. Maybe when i was younger.

Bet they are not paid that much either.

I would volunteer. But they need people who have NOT had covid. As I had a persistent cough in mid March (not tested and now fine) I am not eligible.
They were paying £235. Required up to 11 visits over 6 months

I guess worst case is that they could create a vaccine which is a virus that is more lethal than cv19. From what I've heard they take a chimp virus and engineer it with cv19 proteins.
Sounds really dangerous to me. Fortunately I'm not suitable. Good luck to the brave people who are. They haven't even tested it on animals. It would scare the hell out of me having something this rushed and untested injected into me.

I definitely would.

If I was seriously ill with CV I’d let them try anything

Just had the same conversation with my OH. We agreed he'd do it. Before Covid he was having treatment for incurable (but treatable) cancer which was highly likely to give him several more years of quality life. Due to covid, the oncology dept have shut the doors to him and cancelled his treatment because he's in the shielding group they don't want in the hospital. Without treatment, he will die this Summer. So, to have a vaccine and then hopefully be allowed to restart the treatment, could save his life. What other choice would there be for people in his situation.

@Bessica1970 - what do you do for a job?

If it was as safe as @bessica sats, then yes I would Except a) I don't think they'd want me(old fat diabetic) & b) I'm isolating & doing my damnest not to get it, so probably not a very good guinea pig

they also say that if you do get Covid, you will be treated with usual NHS referral routes, and no special treatment

This makes me far less inclined.

This may be a silly question, but I’m going to ask it anyway.

If they’re doing human trials from this week, does that mean the vaccine could be ready to the U.K. population very soon or are we still looking at months/years? I have no idea how this process works but it sounds promising.

No. Too scared. Am 51 so in a slightly raised risk category, but even if I were younger I think I would be too scared.

They have no idea Day

They don't know if it will be safe, efficacious or how long it will give immunity for. Once they know they will still have to manufacture enough doses.

I see. Thank you

I would. As Im in my early 40's, no health conditions and very fit. I must have a fairly good immune system to as I've never had flu and quite often miss the cold that does the rounds with other people in my life (ie work or family). I do still get them though, but never anything worse than a couple of days of painkillers.

I've often thought about looking into it, didn't realise it was so close to being tested.

Im in the north east though.

@Daybyday89 from what I understand the oxford group say it could be ready by the autumn, IF it all goes well (and it is a big if). However they wouldn’t be able to manufacture massive quantities so I would guess it would be for the highest risk groups first, like we do for the flu vaccine. I’m not an expert though, so feel free to correct me if someone knows better.

I guess worst case is that they could create a vaccine which is a virus that is more lethal than cv19. From what I've heard they take a chimp virus and engineer it with cv19 proteins.
Sounds really dangerous to me. Fortunately I'm not suitable. Good luck to the brave people who are. They haven't even tested it on animals. It would scare the hell out of me having something this rushed and untested injected into me.

Did you bother to read any information about this?

From the information sheet:

ChAdOx1 nCoV-19 is made from a virus (ChAdOx1), which is a weakened version of a common cold virus (adenovirus) from chimpanzees that has been genetically changed so that it is impossible for it to grow in humans. To this virus we have added genes that make proteins from the COVID-19 virus (SARS-CoV-2) called Spike glycoprotein (S), which play an essential role in the infection pathway of the SARS-CoV-2 virus. By vaccinating with ChAdOx1 nCoV-19, we are hoping to make the body recognise and develop an immune response to the Spike protein that will help stop the SARS-CoV-2 virus from entering human cells and therefore prevent infection. Vaccines made from the ChAdOx1 virus have been given to more than 320 people to date, and have been shown to be safe and well tolerated

It also goes on to say it's been tested on laboratory mice and other animal species.

I would consider volunteering if I lived closer. I know a doctor in the area who has volunteered.

The oxford one , if it works, could be ready by the autumn. That’s a big if of course. And the question is also who it works for - does it also work for the older generation . It seems they don’t need a huge amount of data to know it works but I may have misunderstood that. They’re not deliberately exposing people, but I spose if over a few months x % in control group get covid and no one in the vaccine group does then that enables them to widen the testing on the basis that it likely works .

The paradox is that the less covid in the community - the longer the vaccine will take

One of the professors conducting the trial Professor Faust at Southampton was the Professor in charge of a trial that my daughter took part in for swine flu years ago. He is an amazing guy. I had no problems looking into if I was eligible knowing he would of been leading it locally.

They also won't know.how long the.immunity lasts for. The Hep B vaccine for example.isnthree doses (if my.memorybserves me from when I had it) to enable you to build lasting immunity. Without sufficient time lapsed how will they know this?

I applied for the Oxford one and was ruled out as I was in another clinical trial last year.

I just tried to sign up, but I'm ruled out by the fact I've had possible Covid in the last month. Boo. Oh well, I'll try again in a few weeks!

I've participated in research before. It's the only way science moves forward. I'm comfortable with the degree of risk, and I find it fascinating and meaningful.

I’m out of the Bristol catchment and would have asked friends and family to consider if we weren’t. I can’t or I would.

No. I looked into volunteering for the Oxford trial but the possibility the trial vaccine could make covid worse if you catch it made me reconsider.

AmelieTaylor I’m a science teacher 👩‍🏫

Thanks for that! @peajotter