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Studies corner

459 replies

Branster · 02/04/2020 23:00

There are so many snippets of information regarding small tests, case studies and even research from all over the world, some interesting, some surprising, some hopeful. Too many and too small or sometimes obscure to make the main news

If you’d like to share you are welcome to join the thread.

I’ll make a start with these findings from Canada about a potential inhibitor drug

www.sciencedaily.com/releases/2020/04/200402144526.htm

OP posts:
Thread gallery
39
BigChocFrenzy · 14/07/2020 11:31

France: Transplacental transmission of SARS-CoV-2 infection

The baby has since recovered, as have the other reported cases in France

https://www.nature.com/articles/s41467-020-17436-6

BigChocFrenzy · 15/07/2020 21:44

Diagnostic value of skin manifestation of SARS-CoV-2 infection

https://www.medrxiv.org/content/10.1101/2020.07.10.20150656v1.article-info

https://news.sky.com/story/coronavirus-skin-rash-can-be-only-covid-19-symptom-and-should-be-fourth-key-sign-study-finds-12029116

A skin rash can sometimes be the only symptom of people infected with COVID-19,
a study has concluded.

Three types of rashes are identified in the research by King's College London,
leading those behind the study to call for skin rashes to be included as a fourth key symptom of COVID-19.

alreadytaken · 16/07/2020 17:27

preliminary vaccine report, encouraging. www.nejm.org/doi/10.1056/NEJMoa2022483

alreadytaken · 19/07/2020 19:52

impaired interfon response in severe cases science.sciencemag.org/content/early/2020/07/10/science.abc6027

Antibodies decline very rapidly, bad news for vaccines www.medrxiv.org/content/10.1101/2020.07.09.20148429v1

BigChocFrenzy · 20/07/2020 21:59

All-cause excess mortality observed by age group and regions in the first wave of the COVID-19 pandemic in England

https://www.eurosurveillance.org/content/10.2807/1560-7917.ES.2020.25.28.2001239#abstract_content

Studies corner
BigChocFrenzy · 21/07/2020 00:07

Obesity and COVID-19 Severity

Tabulates age, Obesity level, O2 requirement, outcomes for 119,582 COVID-19 positive patients in the USa
Note: paper is from early May

ehrn.org/obesity-and-covid-19-severity/

Studies corner
alreadytaken · 21/07/2020 08:05

Possible disinfection method for public space

www.nature.com/articles/s41598-020-67211-2?fbclid=IwAR0aB85FU7gatzYzw91iZfUNvRwQHejbVVxtT2ldRdAkQsOO-RJbalSU4RA

BigChocFrenzy · 21/07/2020 20:56

The Infectious Nature of Patient-Generated SARS-CoV-2 Aerosol

https://www.medrxiv.org/content/10.1101/2020.07.13.20041632v1.full.pdf

The infectious nature of aerosol collected in this study further suggests that airborne transmission of COVID-19 is possible, and that aerosol prevention measures are necessary to effectively stem the spread of SARS-CoV-2.

alreadytaken · 22/07/2020 13:17

well that paper is not going to encourage me back to the shops, although masks will help.

BigChocFrenzy · 24/07/2020 14:50

Weather & COVID:

https://www.medrxiv.org/content/10.1101/2020.05.21.20108803v1

alreadytaken · 25/07/2020 23:04

Identification s significant antibodies - good for targeting treatments. www.nature.com/articles/s41586-020-2571-7

but will be needed as natural antibodies dont last www.medrxiv.org/content/10.1101/2020.07.09.20148429v1

alreadytaken · 25/07/2020 23:06

outbreak in Israeli school - believed to be because they were allowed to remove masks during a heat wave www.eurosurveillance.org/content/10.2807/1560-7917.ES.2020.25.29.2001352

BigChocFrenzy · 28/07/2020 10:55

Outcomes of Cardiovascular Magnetic Resonance Imaging in Patients Recently Recovered From Coronavirus Disease 2019 (COVID-19)

https://jamanetwork.com/journals/jamacardiology/fullarticle/2768916

"In this study of a cohort of German patients recently recovered from COVID-19 infection,

CMR revealed cardiac involvement in 78 patients (78%) and ongoing myocardial inflammation in 60 patients (60%), independent of preexisting conditions, severity and overall course of the acute illness, and time from the original diagnosis.

These findings indicate the need for ongoing investigation of the long-term cardiovascular consequences of COVID-19."

BigChocFrenzy · 31/07/2020 20:50

JAMA Pediatrics: Age-Related Differences in Nasopharyngeal Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Levels in Patients With Mild to Moderate Coronavirus Disease 2019 (COVID-19)

https://jamanetwork.com/journals/jamapediatrics/fullarticle/2768952

Our analyses suggest children younger than 5 years with mild to moderate COVID-19 have high amounts of SARS-CoV-2 viral RNA in their nasopharynx compared with older children and adults.

BigChocFrenzy · 31/07/2020 21:54

I meant to add re the above paper
that they found under-5s carry more of the viral nucleic acid that the other age groups,
but that doesnt necessarily mean live virus that can infect adults around them

alreadytaken · 01/08/2020 22:59

if I was a teacher wouldnt want to be around children with symptoms, that means sending more children home.

Pretty good response to vaccines in monkeys - but they havent found out how long it lasts. www.nature.com/articles/s41586-020-2607-z_reference.pdf

Cross reactive T cells in healthy blood donors - possibly useful for them but not convinced it's going to make a massive difference. www.nature.com/articles/s41586-020-2598-9

alreadytaken · 04/08/2020 08:23

Report on summer camp outbreak in America, despite negative test being required before attendance. Attack rate was higher in the 6-10 age group than older children. Lower rate in teenagers possibly because staff members were supposed to wear cloth masks.

www.cdc.gov/mmwr/volumes/69/wr/mm6931e1.htm?s_cid=mm6931e1_w

alreadytaken · 04/08/2020 08:46

This reply has been deleted

Message withdrawn at poster's request.

alreadytaken · 04/08/2020 08:47

sorry - posted on wrong thread.

BigChocFrenzy · 05/08/2020 15:52

BMJ Editorial: Long term respiratory complications of covid-19

https://www.bmj.com/content/370/bmj.m3001

"Substantial population morbidity is likely"

The extent and severity of the long term respiratory complications of covid-19 infection remain to be seen, but emerging data indicate that many patients experience persistent respiratory symptoms months after their initial illness.1

Recently published guidance by the NHS lays out the likely aftercare needs of patients recovering from covid-19 and identifies potential respiratory problems including chronic cough, fibrotic lung disease, bronchiectasis, and pulmonary vascular disease.

The evidence for these possible sequelae is largely derived from acute manifestations of covid-19, along with extrapolations from the 2003 outbreak of severe acute respiratory syndrome (SARS) and data on acute respiratory distress syndrome (ARDS).2
....
To summarise, persistent respiratory complications following covid-19 may cause substantial population morbidity, and optimal management remains unclear.

Prospective studies are under way to evaluate these complications further and to identify people at greatest risk.
Meanwhile, a pragmatic approach to primary care management might include first line investigations such chest radiography and oxygen saturation measurements, with referral to secondary care where lung pathology needs investigation.
Integrated support from a broader primary care team should be considered for patients with more complex symptoms, including those with disproportionate functional impairment.

BigChocFrenzy · 08/08/2020 17:58

Looks v promising for treatment or vaccine:

www.biorxiv.org/content/10.1101/2020.08.06.238915v1

Critically, SARS-BLOCKâ„¢ peptides are able to potently and competitively inhibit SARS-CoV-2 S1 spike protein receptor binding domain (RBD) binding to ACE2, the main cellular entry pathway for SARS-CoV-2,
while also binding to neutralizing antibodies against SARS-CoV-2.

In order to create this potential therapeutic antidote-vaccine, we designed, simulated, synthesized, modeled epitopes, predicted peptide folding, and characterized behavior of a novel set of synthetic peptides.

alreadytaken · 08/08/2020 20:14

Israeli study suggests those with low vitamin D levels are both more likely to become infected and more likely to need hospital treatment. www.medrxiv.org/content/10.1101/2020.07.01.20144329v1

BigChocFrenzy · 08/08/2020 23:38

CDC: _Hospitalization Rates and Characteristics of Children Aged

alreadytaken · 09/08/2020 09:02

Good news for those on ACE inhibitors - no increased risk

heart.bmj.com/content/early/2020/07/31/heartjnl-2020-317393

alreadytaken · 10/08/2020 11:02

preprint re a saliva test www.medrxiv.org/content/10.1101/2020.08.03.20167791v1

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