Studies corner

[Branster]

There are so many snippets of information regarding small tests, case studies and even research from all over the world, some interesting, some surprising, some hopeful. Too many and too small or sometimes obscure to make the main news

If you’d like to share you are welcome to join the thread.

I’ll make a start with these findings from Canada about a potential inhibitor drug

www.sciencedaily.com/releases/2020/04/200402144526.htm

[alreadytaken]

Covid causes changes in the brain

www.nature.com/articles/s41586-022-04569-5_reference.pdf

[alreadytaken]

Vitamin D intervention study showing reduced admission to ICU and reduced death. pubmed.ncbi.nlm.nih.gov/34097036/

[alreadytaken]

Preprint looking at whether you can find a genetic base for severe covid www.medrxiv.org/content/10.1101/2021.06.21.21257822v1

[alreadytaken]

Preprint suggesting vitamin B12 may be useful www.biorxiv.org/content/10.1101/2021.06.25.449609v1

[alreadytaken]

More evidence of the damage covid does even in apparently "mild" cases in young people physoc.onlinelibrary.wiley.com/doi/10.1113/EP089481

[Quarantino]

Yes, thanks for carrying on!
Asthma drug budesonide seems to shorten covid recovery times:
www.principletrial.org/results

[alreadytaken]

Significant readmission to hospital and death in those admitted to hospital with covid. www.bmj.com/content/372/bmj.n693

[Geamhradh]

[quote alreadytaken]Italy doesnt think schools drive covid infection www.thelancet.com/journals/lanepe/article/PIIS2666-7762(21)00069-7/fulltext[/quote]
That's probably because of compulsory mask wearing and SD in schools in Italy, plus most regions vaccinating teachers and school staff as a priority.

[notrub]

[quote alreadytaken]Italy doesnt think schools drive covid infection www.thelancet.com/journals/lanepe/article/PIIS2666-7762(21)00069-7/fulltext[/quote]
Wow - so a country has an opinion??

Was it spoken or written? Which bit of the country does the communicating? That leg looks like it could hold an enormous pen... or did Etna just twerk the psychic medium and you picked up the vibes?

[alreadytaken]

Italy doesnt think schools drive covid infection www.thelancet.com/journals/lanepe/article/PIIS2666-7762(21)00069-7/fulltext

[alreadytaken]

Effectiveness of testing air passengers

www.oxera.com/publications/effectiveness-of-dual-testing-schemes-for-air-passengers/?utmsource=UKH+CV19+-+update+email&utmcampaign=4f493ef9e9-EMAILCAMPAIGN8720201258COPY01&utmmedium=email&utmterm=0_5608eb3d21-4f493ef9e9-57364442

and rapid tests that could give results at the airport

www.reuters.com/article/uk-health-coronavirus-britain-20second/britain-approves-20-second-covid-19-test-distributor-says-idUSKBN2BI16J?rpc=401&

[alreadytaken]

@kittykatkit Thanks, I have been posting less but will add some more after the encouragement

Pregnant and breastfeeding mothers who are vaccinated pass on covid antibodies www.ajog.org/article/S0002-9378(21)00187-3/fulltext

[kittykatkit]

Just wanted to say thanks for continuing to add studies. Your thread is on my watchlist!

[alreadytaken]

Changes to the microbiome reduces time to resolution of symptoms in those with covid who have comorbidites

www.globenewswire.com/news-release/2021/01/14/2158541/0/en/Kaleido-Biosciences-Announces-Positive-Interim-Results-of-Controlled-Study-of-KB109-in-Patients-with-Mild-to-Moderate-COVID-19.html

[alreadytaken]

CBD compound from cannabis has been found to stop COVID-19 replication in lung epithelial cells

www.goodnewsnetwork.org/cbd-was-found-to-prevent-viral-rna-expression-and-reverse-gene-changes-in-infected-lung-cells/

[alreadytaken]

Antibodies mutate too - good news theconversation.com/coronavirus-is-evolving-but-so-are-our-antibodies-156810

[alreadytaken]

Effect on behaviour of misinformation and political views in America www.brookings.edu/research/how-misinformation-is-distorting-covid-policies-and-behaviors/

[alreadytaken]

Protection against covid reinfection lower in the elderly in Denmark linkinghub.elsevier.com/retrieve/pii/S0140673621005754

[alreadytaken]

small study suggests nitric oxide sprays are worth watching www.goodnewsnetwork.org/taffix-success-and-other-covid-19-nasal-sprays/

[CherryBlossomOsaka]

An open-label randomized study of 87 vitamin D deficient hospitalized Covid patients found that vitamin D supplementation (60,000 IU/day for 8-10 days) lowered inflammatory biomarkers.

Inflammatory biomarkers are compounds in the bloodstream which are excessive during cytokine storms.

Therapeutic improvement in vitamin D to 80-100 ng/ml has significantly reduced the inflammatory markers associated with COVID-19 without any side effects. Hence, adjunctive Pulse D therapy can be added safely to the existing treatment protocols of COVID-19 for improved outcomes.

www.researchsquare.com/article/rs-152494/v1


All hospitals should be using this protocol - Dr Quinton is successfully using this type of protocol in Newcastle Hospital which is the second best performing England covid 19 hospital.

This is the 30th replication of these types of results in a worldwide study. Please do not reply that this is not a double blind RCT which would result in many placebo patients dying - we already know.

[alreadytaken]

Gym outbreaks - but from classes
www.nytimes.com/2021/02/24/health/coronavirus-gyms-outbreaks.html

[alreadytaken]

If the virus evades vaccines there will be other ways to deal with it. news.osu.edu/tricking-the-novel-coronavirus-with-a-fake-handshake/

[CherryBlossomOsaka]

How quickly proven science is so easily forgotten and purposely ignored as irrelevant.

We already know and have RCTs that respiratory virus serious outcomes are mitigated by optimal vitamin d3 serum lebels.

Results: We identified 25 eligible RCTs (a total of 11,321 participants, aged from 0 to 95 years.)

Vitamin D supplementation reduced the risk of ARI among all participants.

Vitamin D supplementation was safe, and it protected against ARIs overall. Very deficient individuals and those not receiving bolus doses experienced the benefit.

This is totally ignored 2019 pre-covid science.

Scientists have already proved that increasing our vitamin d3 serum increase our protection against severe outcomes from respiratory viruses - it's not really such a big deal.

pubmed.ncbi.nlm.nih.gov/30675873/

[alreadytaken]

Latest vitamin D study to be published - negative results but again showing that a lot of poor quality research gets published.

jamanetwork.com/journals/jama/fullarticle/2776738?guestAccessKey=f5804d82-41ff-44f8-829f-90c98f52e117&utm_source=silverchair&utm_medium=email&utm_campaign=article_alert-jama&utm_content=olf&utm_term=021721

In this study the treatment group were more likely to be male, black, diabetic, have hypertension and were heavier - all factors known to be associated with poor outcomes in covid. This is a problem with simple randomisation and a small sample, but a problem that could have been at least partially avoided by using a stratified sample. Sample is unfortunately too small to compare outcomes within subgroups.

They were given a single dose on average 10 days after symptoms developed. While this lifted them out of severe deficiency it isnt necessarily enough to be beneficial. They had more deaths but less need for oxygen and fewer admissions to ICU.

Disappointing study - but given the considerable differences between treatment and control group it would have to have had massive benefit to be detected. Not enough to stop me taking vitamin D.

[MedSchoolRat]

Oh dear, silly me to notice this late, SSRN actually retracted the preprint about vitamin D in Spanish covid patients.

Do you know how BAD an article has to be to get retracted from preprint? In this case, it was absence of ethics approval that the commentators grabbed onto in detail and probably was the last straw.

COVID-19 scientific literature is indeed a disaster area.
Fun to read about little cutting edge studies gals, but don't believe any of it matters without a lot of validation work.