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Studies corner

459 replies

Branster · 02/04/2020 23:00

There are so many snippets of information regarding small tests, case studies and even research from all over the world, some interesting, some surprising, some hopeful. Too many and too small or sometimes obscure to make the main news

If you’d like to share you are welcome to join the thread.

I’ll make a start with these findings from Canada about a potential inhibitor drug

www.sciencedaily.com/releases/2020/04/200402144526.htm

OP posts:
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alreadytaken · 10/09/2020 16:42

Not massively impressed by the latest vitamin D study as they were largely using out of date vitamin D levels and didnt even say if they had adjusted them for seasonal effects. However the interesting bit was the liquid v tablets bit. It's actually a fat soluble vitamin so taking it with some form of fat may help absorption. I dont know what is in their vitamin D drops but my guess would be there is some oil in there. You can get the same effect by taking your tablets with a meal that contains some fat - not necessarily a high fat meal, just a small amount.

BigChocFrenzy · 11/09/2020 13:41

Transmission dynamics of COVID-19 in household and community settings in the United Kingdom

Transmission calculations - age, incubation time, attack rate etc BEFORE lockdown
Dataset was people who developed symptoms between 24th January 2020 and 13th March 2020

https://www.medrxiv.org/content/10.1101/2020.08.19.20177188v1

"In the UK, prior to the implementation of social and physical distancing measures, we estimate an

overall household SAR of 37% < secondary attack rate = probability of transmission between first case and each household contact>
a serial interval of 4.67 days
an R0 of 1.85
and a household reproduction number of 2.33

We find lower secondary attack rates in larger households

There is some suggestion that where the primary case is a child, household SARs are higher and the serial interval is shorter.

Conversely serial intervals were longer if the household contact was a child or an older adult.
Using point source exposures we estimate a mean incubation period of around 4.5 days.

Our estimated household SAR in the UK is greater than that reported in China, Taiwan and South Korea estimated household SARs ranging from 5% to 30% (4-10).

Making comparisons across studies is challenging due to differences in follow-up, symptom ascertainment or testing of contacts,
however, the higher household SAR in the UK could reflect differences in isolation and infection control measures taken to reduce spread.

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BigChocFrenzy · 11/09/2020 14:19

Spiegelhalter: Use of “normal” risk to improve understanding of dangers of covid-19

https://www.bmj.com/content/bmj/370/bmj.m3259.full.pdf

David Spiegelhalter@d_spiegel

My BMJ paper on using the idea of ‘normal’/background/actuarial risk to communicate
the huge range of risks from COVID-19 experienced by people of different ages
...
Risk of catching and dying from Covid-19 doubles for each 6 years older,
all the way from childhood to old age, overwhelms other factors.

Extraordinary consistent gradient:
13% increase per year like some horrible form of compound interest
......
The risk of death from COVID-19 if infected,
roughly similar to the risk of dying from all other causes over the next year,
therefore essentially doubling the risk.

Bit more than a year's worth for over 55s,
less for under 55s
......
Conclusion:
dominating effect of age highlights the need for caution at intergenerational meetings.

As a simple guide, younger people should be particularly cautious around those over 55

(NB Only look at death: do not yet have good data on long-term morbidity)

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BigChocFrenzy · 11/09/2020 19:26

Royal Society: Reproduction number (R) and growth rate (r) of the COVID-19 epidemic in the UK

methods of estimation, data sources, causes of heterogeneity, and use as a guide in policy formulation

Explanations in depth - 85 pages is their "rapid" overview ! - with comparison to other diseases, lots of maths to enjoy

royalsociety.org/-/media/policy/projects/set-c/set-covid-19-R-estimates.pdf

alreadytaken · 12/09/2020 10:02

Some good news

"The vast majority of hospitalized COVID-19 patients show lung damage 6 weeks after discharge, but this proportion drops significantly after 12 weeks, suggesting that the lungs have a self-repair mechanism, researchers report."

www.medscape.com/viewarticle/937263

BigChocFrenzy · 12/09/2020 12:45

Overview: School Transmissions

<a class="break-all" href="http://go.mumsnet.com/?xs=1&id=470X1554755&url=threader.app/thread" target="_blank">http://go.mumsnet.com/?xs=1&id=470X1554755&url=threader.app/thread/

AlasdairMunro@apsmunro (Paediatric Registrar | Clinical Research Fellow Paediatric Infectious diseases @southamptonCRF)
....
Summary:

  • If prevalence high in the community, it will be high in schools and some will transmit
  • Isolated cases result in low transmission
  • Infection prevention works

..... He discusses several studies + tables ....

What does this mean?

Careful reopening of schools in areas of low community prevalence with good, basic infection prevention measures can work

Israel had problems, but Denmark, Finland, Norway, Netherlands, Switzerland, Iceland, Singapore etc managed it well

alreadytaken · 12/09/2020 14:15

Another vitamin D study, this one German and still correlation rather than intervention www.mdpi.com/2072-6643/12/9/2757/htm

BigChocFrenzy · 13/09/2020 14:12

Royal Society & Wellcome Trust: The effectiveness of social bubbles as part of a Covid-19 lockdown exit strategy, a modelling study

wellcomeopenresearch.org/articles/5-213

Conclusions: If managed appropriately, social bubbles can be an effective way of extending contacts beyond the household while limiting the increase in epidemic risk.

whatsnext2 · 13/09/2020 20:11

Another vitamin d study Showing good results

www.ncbi.nlm.nih.gov/pmc/articles/PMC7456194/

alreadytaken · 13/09/2020 20:56

That study has been posted before, but as a preprint. However if those results held true in large studies it would be the most effective treatment there is. The imbalance in the control groups - more diabetics and men in the control, but slightly older in the intervention groups - mean I'd like to see other studies.

If I get symptoms suggestive of Covid I shall take extra vitamin D though.

IceCreamSummer20 · 13/09/2020 22:28

(i) limiting interaction to a few repeated contacts

This makes so much sense, really good to see some studies looking at how we as the public can be most effective. Everyone does seem a but weary and confused. When we are in it for the long haul, it could massively help if we took the latest studies and shared them to raise awareness of priority actions. The above was the most effective, then that would be really good to share.

alreadytaken · 14/09/2020 12:51

Risk of transmission on train - but Chinese trains. Doesnt mention mask wearing but I'd assume they wore them since its China. www.southampton.ac.uk/news/2020/07/train-transmission.page

BigChocFrenzy · 14/09/2020 13:41

Why "herd immunity" by just letting it rip costs far more lives

Adam Kucharski @AdamJKucharski (Mathematician/epidemiologist at LSHTM, WellcomeTrust)

I still see the persistent, but incorrect, claim that control measures just delay - rather than reduce - the impact of an epidemic.

A thread on the problem of 'overshoot'... 1/

This claim seems to arise from a misunderstanding about two related, but different metrics:

the % of people infected during an epidemic,

and the point at which immunity leads to a decline in transmission 2/

In an uncontrolled epidemic, 'herd immunity' is reached at the peak (because R

BigChocFrenzy · 14/09/2020 13:58

...

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BigChocFrenzy · 14/09/2020 14:02

Notes:

The UK is far from herd immunity with overall < 10% immunity,
so it wouldn't be 20% on top of current deaths, but of a much higher number of deaths

The UK has ~12 x the population density of Sweden
which is a major factor in infection spread & hence deaths
Scandinavian countries may be able to have a lower "effective herd immunity" because very low popultion density is in itself a major SD measure / infection control.

When we compare Sweden to other Scandinavian countries, we see Sweden has 5-12 x total deaths / million population

CoffeeandCroissant · 14/09/2020 17:47

Study looking at cohort data of periods of reinfection with seasonal coronaviruses (NL63, 229E, HKU1, OC43). Reinfections are quite common, generally follow a pattern of susceptibility after 12 months.

Hypothesises that similar pattern will occur for Covid-19. But refers to protective immunity, so while people were reinfected, it doesn't necessarily show that people got sick each time (could be asymptomatic on reinfection) or that they were infectious.

www.nature.com/articles/s41591-020-1083-1

BigChocFrenzy · 16/09/2020 12:18

Germany Study: Sniffer dogs to detect Corona

https://www.tiho-hannover.de/aktuelles-presse/pressemitteilungen/pressemitteilungen-2020/pressemitteilungen-2020/article/schnueffelnd-zur-coronadiagnose-1/

A study by the Hannover Uni of Veterinary Medicine, Hannover Medical school and the German armed forces
found that dogs could be trained to discriminate between human saliva samples infected with SARS-CoV-2 and non-infected samples with a 94% success rate overall.

The hope of researchers is that this method of detection could be one day be used in public areas such as airports, sporting events and other mass gatherings (in addition to laboratory testing)

BigChocFrenzy · 16/09/2020 12:22

I just found the English language paper to the above:

Scent dog identification of samples from COVID-19 patients – a pilot study

bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-020-05281-3#author-information

BigChocFrenzy · 16/09/2020 15:29

CDC: _SARS-CoV-2–Associated Deaths Among Persons Aged

alreadytaken · 16/09/2020 17:30

Impressive results from the dogs. They were trained on hospital patients so need to know if they can also detect asymptomatic - but I'd be very pleased to see them at airports.

whatsnext2 · 18/09/2020 17:45

A systematic review of antibody mediated immunity to coronaviruses

www.nature.com/articles/s41467-020-18450-4

alreadytaken · 19/09/2020 18:21

Timing of transmission - roughly 40% of transmission events occurred before the onset of symptoms, and around 35% took place on the day that symptoms appeared or on the following day

www.medrxiv.org/content/10.1101/2020.09.04.20188516v2.full.pdf+html

alreadytaken · 20/09/2020 14:45

Convalescent plasma may not be a great idea www.medrxiv.org/content/10.1101/2020.09.17.20196212v1

alreadytaken · 20/09/2020 14:47

UV light disinfection looks promising. I'd like to see other studies www.hiroshima-u.ac.jp/en/news/60119

alreadytaken · 20/09/2020 14:48

Anti Covid measures are providing some protection against flu www.cdc.gov/mmwr/volumes/69/wr/mm6937a6.htm

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