Meet the Other Phone. Protection built in.

Meet the Other Phone.
Protection built in.

Buy now

Please or to access all these features

Covid

Mumsnet doesn't verify the qualifications of users. If you have medical concerns, please consult a healthcare professional.

Studies corner

459 replies

Branster · 02/04/2020 23:00

There are so many snippets of information regarding small tests, case studies and even research from all over the world, some interesting, some surprising, some hopeful. Too many and too small or sometimes obscure to make the main news

If you’d like to share you are welcome to join the thread.

I’ll make a start with these findings from Canada about a potential inhibitor drug

www.sciencedaily.com/releases/2020/04/200402144526.htm

OP posts:
Thread gallery
39
BigChocFrenzy · 21/08/2020 17:48

Pediatric SARS-CoV-2: Clinical Presentation, Infectivity, and Immune Responses

https://www.jpeds.com/article/S0022-3476(20)31023-4/fulltext

Viral load in respiratory secretions of children was high, despite mild or absent symptoms
.....
Pediatric patients displayed no apparent difference in viral load compared with adults requiring intubation for severe SARS-CoV-2 infection when stratified by time.

Viral load in children in the asymptomatic/early infection phase was significantly higher than in hospitalized adults with severe disease with over 7 days of symptoms

alreadytaken · 21/08/2020 19:17

@BigChocFrenzy Sorry that still isnt working. I put Ethics, assessing vaccine safety, need and which groups to prioritise into search on that page and that turned it up but when I previewed the link it wouldnt work either.

BigChocFrenzy · 21/08/2020 21:40

@alreadytaken

This is the RKI page that references the paper and I have marked the link to click:

https://www.rki.de/DE/Content/Infekt/EpidBull/Archiv/2020/35/Art_01.html

(then copy the link into Google translate if you aren't fluent in German)

Studies corner
BigChocFrenzy · 22/08/2020 21:38

Get a gadget showing temperature and humidity for your home - my clock in the living room has this

BigChocFrenzy · 22/08/2020 21:44

Assessing the Age Specificity of Infection Fatality Rates for COVID-19: Systematic Review, Meta-Analysis, and Public Policy Implications

Could be referenced whenever middle-aged teachers expressing concern about COVID risk are asked if they would travel in a car

www.medrxiv.org/content/10.1101/2020.07.23.20160895v3.full.pdf

Results:
Our analysis finds an exponential relationship between age and IFR for COVID-19

The estimated age-specific IFRs are close to zero for children and younger adults,
but rise to about 0.3% for ages 50-59,
1.3% for ages 60-69,
and 4% for ages 70-79,
15% for ages 80-89,
and 25% for ages 90 and above.....

Discussion:
These results indicate that COVID-19 is hazardous not only for the elderly
but for middle-aged adults, for whom the infection fatality rate is more than 50 times greater than the annualized risk of a fatal automobile accident.

BigChocFrenzy · 22/08/2020 21:54

Of course, personal risk also depends on risk of catching COVID in the first place, which will be much lower in some areas than others

alreadytaken · 23/08/2020 20:21

promising breath test pubs.acs.org/doi/abs/10.1021/acsnano.0c05657

alreadytaken · 23/08/2020 20:24

report, rather than research, of a Korean starbucks where visitors got infected but mask and glove wearing staff were not www.insight.co.kr/news/299857?fbclid=IwAR3XtrhPNuF2EFE7ufVWJs0ZHs6tLAYilO7hgbhkCb6CIt4B3YtyGVpaa4E

CoffeeandCroissant · 24/08/2020 14:02

Microbiology department of University of Hong Kong suggests they have proof via genome sequencing that a 33 year old was reinfected with Covid19. First infection was symptomatic and occurred in March in Hong Kong. Second infection was asymptomatic and occurred in August on a trip to Spain, was detected by routine testing on arrival in Hong Kong after they returned from Spain via the UK.
mobile.twitter.com/cwylilian/status/1297830744509698050.

However experts have said that short term reinfection, while possible is likely to be extremely rare and it's very difficult to draw any conclusions from a subject number of just one person, more research needed...

CoffeeandCroissant · 24/08/2020 14:23

Expert reaction to 'first confirmed case of COVID-19 re-infection' in Hong Kong patient.

^There are reports of a confirmed case of COVID-19 re-infection in a Hong Kong patient.

Dr Jeffrey Barrett FMedSci, Senior Scientific Consultant for COVID-19 Genome Project, Wellcome Sanger Institute, said:

“It is very hard to draw firm conclusions from the press release alone (i.e. without the paper that it relates to). Some of the paper has been published on social media, which fills in some gaps (though we’re still waiting for the full paper).

“This is certainly stronger evidence of re-infection than some of the previous reports because it uses the genome sequence of the virus to separate the two infections. It seems much more likely that this patient has two distinct infections than a single infection followed by a relapse (due to the number of genetic differences between the two sequences).

“An important point about this one case, which is not mentioned in the press release, is that the second infection is asymptomatic. It was caught by screening tests on returning passengers at HK airport, and the individual never developed any symptoms from their second infection.

“It is very hard to make any strong inference from a single observation! Given the number of global infections to date, seeing one case of reinfection is not that surprising even if it is a very rare occurrence. I think their ‘implications’ are far too broad given that they have seen just one instance. This may be very rare, and it may be that second infections, when they do occur, are not serious (though we don’t know whether this person was infectious during their second episode).”

Dr Simon Clarke, Associate Professor in Cellular Microbiology at the University of Reading, said:

“The significant thing here is that being re-infected with a mutated strain demonstrates that it is more likely to be re-infection, rather than the same infection that has hung around because the virus has not actually been got rid of, as some people have suggested happens. The finding of a mutant strain is absolutely nothing to be shocked or surprised by and I think that some journalists don’t quite understand that – it would actually be more interesting if there were no mutations cropping up.” ^

sciencemediacentre.org/expert-reaction-to-first-confirmed-case-of-covid-19-re-infection-in-hong-kong-patient/

CoffeeandCroissant · 24/08/2020 16:53

Study of 293 children with Covid19

➡️ There was no difference in viral load between symptomatic and asymptomatic children.

➡️ Asymptomatic infections were common, and were most common in children of primary school age.

0-5: 25%
6-13: 39%
14-20: 24%

mobile.twitter.com/DrZoeHyde/status/1297912567885492224

Link to study (pdf) in tweet below:
mobile.twitter.com/EckerleIsabella/status/1297900183242584065

CoffeeandCroissant · 24/08/2020 16:57

Forgot to add, study above is from the US (Duke University School of Medicine, Durham, NC) and is a pre print.

WhenSheWasBad · 24/08/2020 19:39

So glad I found this thread. Saw the news about reinfection and my heart sank.

Going to have a read of coffees links.

CoffeeandCroissant · 24/08/2020 19:56

Also a good short Twitter thread here on reinfection: mobile.twitter.com/VirusesImmunity/status/1297890418168860674

BigChocFrenzy · 25/08/2020 00:21

A sample of 1 tells us little, other than it confirms re-infection can happen

  • there have been several other claims, but this is the first with proof

We don't know how rarely / often a 2nd infection will happen

  • COVID was in HK several weeks earlier than in Europe and HK had 2 million in Europe

Only 7% of people in the UK have antibodies indicating previous infection, so someone would have to be very unlucky to catch it twice

We don't know how many 2nd infections will be asymptomatic in middle-aged or elderly people

BigChocFrenzy · 25/08/2020 00:22

ECDC: COVID-19 in children and the role of school settings in COVID-19 transmission

www.ecdc.europa.eu/en/publications-data/children-and-school-settings-covid-19-transmission

BigChocFrenzy · 26/08/2020 21:45

RKI Study of Bavarian town of Bad Feilnbach

https://www.rki.de/DE/Content/Gesundheitsmonitoring/Studien/cml-studie/FactsheetBadd_Feilnbach.html

The 2nd of a series of large-scale studies of local areas by the RKI (German public health Inst)
taking both swabs and blood samples, plus detailled questionaires

Time Period: June 23 to July 4, 2020
Participants: 2,153 adults
Sampling: representative random sample from the population register, invitation for
adult voluntary participation

  • 10% had a past or present positive swab test, but only 6% had IgG antibodies

  • Asymptomatic cases: 14.5 % of those with antibodies

  • 85.5 % had at least one of the symptoms (fever, shortness of breath / shortness of breath,
    Pneumonia, runny nose, cough, painful breathing, sore throat, loss of taste / smell)
    but no cases were acute (serious enough for hospitalisation)

  • The study detected 2.6 x more infections than previously known - symptoms not recognised

whenwillthemadnessend · 27/08/2020 08:09

New info about natural mosquito repellent protecting again virus particles for up to four hours just coming out in newspapers today.

Might be interesting as a preventative if used on hands and faces exposed skin in crowded indoors places. .

alreadytaken · 27/08/2020 10:37

I wondered if anyone would be looking at the natural insect repellent - this is why it's probably not worth trying to find any remaining stocks

"However, he added: 'The insect repellent formulation also contains ethanol and isopropanol (short-chain alcohols) and these are probably equally effective. As far as I can see they did not actually do a statistical significance test of the alcohols vs. the insect repellent, but they look equally active to me.

'My feeling is that we need to be cautious as it may be the alcohol carrier rather than the citriodiol killing the virus in the Mosi-guard.

'One advantage might be that citriodiol would be quite a lot less volatile than ethanol or isopropanol which would make probably it easier to apply. It would probably be an acceptable substitute in the field for using soap and water. It is probably of similar effectiveness.'"

Wash your face as well as your hands when you come indoors and sterilise your phone - those have been my recommendations from the start.

BigChocFrenzy · 27/08/2020 11:21

BMJ paper: Two metres or one: what is the evidence for physical distancing in covid-19?

Nuance matters
Necessary social distance depends on masks, occupancy, indoor vs. outdoor, silence vs. speaking vs. shouting, ventilation.....

https://www.bmj.com/content/370/bmj.m3223

More nuanced model
Environmental influences are complex and are likely to be mutually reinforcing.

This is shown, for example, in meat packing plants, where outbreaks have been attributed to the combination of high levels of worker contagion, poor ventilation, cramped working conditions, background noise (which leads to shouting), and low compliance with mask wearing.

Similar compound risk situations might occur in other crowded, noisy, indoor environments, such as pubs or live music venues.

Physical distancing rules would be most effective if they reflected graded levels of risk.

Figure 3 presents a guide to how transmission risk may vary with setting, occupancy level, contact time, and whether face coverings are worn.

These estimates apply when everyone is asymptomatic.

In the highest risk situations (indoor environments with poor ventilation, high levels of occupancy, prolonged contact time, and no face coverings, such as a crowded bar or night club)
physical distancing beyond 2 m and minimising occupancy time should be considered.

Less stringent distancing is likely to be adequate in low risk scenarios.

People with symptoms (who should in any case be self-isolating) tend to have high viral load and more frequent violent respiratory exhalations.

Studies corner
BigChocFrenzy · 27/08/2020 17:41

Porton Down: Experimental survival of SARS-CoV-2 on an insect-repellent-treated surface

https://assets.publishing.service.gov.uk/government/uploads/system/uploads/attachmentdata/file/912171/202007299_Citriodiol-O.pdf

CoffeeandCroissant · 27/08/2020 21:41

"COVID-19 was initially identified as a respiratory disease, but scientists now appreciate that it also affects several other organs in the body, including the heart. Heart damage is a major determinant of COVID-19 related deaths, and even patients who experience only mild COVID-19 symptoms exhibit signs of cardiac dysfunction several months after recovery."
gladstone.org/news/new-insights-how-covid-19-causes-heart-damage

Preprint: www.biorxiv.org/content/10.1101/2020.08.25.265561v1

"Initially #SARSCoV2 was considered a respiratory virus. New @GladstoneInst
findings in both iPSC-> heart cells & autopsy indicate it's a heart virus, w/ a distinct pattern:
—myofibrillar fragmentation
—loss of nuclear DNA
—"complete dissolution of the contractile machinery"
mobile.twitter.com/EricTopol/status/1299027542272172032

Prokupatuscrakedatus · 28/08/2020 07:47

I wonder as a layperson:
Is this type of heart damage specific to C19 or is it the same type you can get following influenza (an uncle was left with a damaged heart after he recovered from 'real flu') or scarlet fever??