Immune/NK cells pred thread #34

[Hopeandfaith1990]

Hi all, started a new thread as the old one was full. Not sure if this is the way to do it but I've c&p'd the list of people on the previous one as much as poss:

Old thread here: https://www.mumsnet.com/talk/conception/5228367-immunenk-cells-pred-thread-33?page=40

@Jecca88
@Gizmo1983
@Deerdancer34
@Objectiontime
@SWMum9
@TammyinCork
@Newbeginnings22023
@Fletchasketch
@Morgan236
@CarpeDiem75
@ALittleLight
@MC8
@venusStarr
@Gizmo1983
@Carportforme
@Meg310532
@Newbeginnings22023
@recurrentmis
@hopefulH
@v60
@lozzmax
@fleur89
@motherofshihtzus
@sunflower360
@kea1990
@sprinkleofbabydust
@star2022
@rumandspinach
@ems123456789
@rainbowsunshine81
@mamaw05
@thornters
@elarcoiris

@Hopeandfaith1990 I am holding my breath! I think you're right to wait a bit and definitely a few days before going back to school! Everything is crossed tightly. Don't the days feel so long.... Keep as distracted as possible, have a focus for each day to concentrate on 💕

@Holdinghope2025 Welcome, sorry you have to be here. I'm not surprised you are tired, it's a long, emotionally and physically, all consuming journey but groups like this make it a little bit better. Have you found a clinic you are happy with now? Also I found Talking Therapy or these forums very therapeutic, helps to unload some of the weight. Sending you much love 💕

@Hopeandfaith1990 @Deerdancer34 thank you both for your kindness and thoughts. Yes we moved our embryos to a new clinic prior to the last fet . I was on dexa from a week out from fet and switched over to pred day of transfer. Dexa made me so hungry wow but I loved being on pred and didn’t want to come off tbh ! Yes I do think a lot about getting remaining embryos tested however I’m not keen to thaw and re freeze and thaw again so we are going to leave them be and if we need another cycle any embryos we get from that we will test before freezing. . . Overwhelming stuff. It’s so hard isn’t it as even if all of the immune side of things aligns there are so many other factors.

I hope you’re both having a peaceful Sunday morning wherever you are 😊

Hey ladies,

trying to catch up.

@Hopeandfaith1990 how are you getting on not testing? Thinking of you my love. Got the day 5 update and we have 5 to send off so far for PGTA - which I am happy with and hoping we get 3 out of that. Also might have a few more tonight / tomorrow so another anxious wait. Been feeling so bloated and in quite a bit of pain post Egg retrieval - it actually feels worse than post D&C. I think I am also having the hormone crash.

welcome @Holdinghope2025 - I’m so sorry to hear about your awful journey. Have the NhS offered anything for the endo? I agree with the others that pred should be started with ovulation day. How much hydroxy are you on and how long have you been taking it? Dr s said it needs a build up for 6 weeks ahead of a pregnancy. Have you ever tried intralipids?

@Blossomvic thats so annoying about the referral for kings. Are you now outside the catchment? Have you got anyone that is family that lives in the area?

That's wonderful news @Jecca88 and fingers crossed for the ones still in the running. Do you know how long it'll take to get the results back? I totally agree re post egg collection roughness, it honestly took me over a full week to feel 'normal' again and I was shocked as I thought I'd be right back to it the next day haha. I also remember the hormone crash, be kind to yourself.

I'm okay thanks - not feeling very positive tbh, I am 7dp5dt today and I have NO symptoms at all, no sore boobs, no cramps anymore, nothing. I want to test but I'm also scared to leave this little bubble of PUPO. Gah.

Thank you @Jecca88 . I’m on the gynae waiting list on nhs just now . I need a lap I know that however I want to do another retrieval first . Hopefully by the time we get past our next retrieval I’ll be near top of list for a lap on nhs. We shall see. I just started hydroxy 400mg 2 weeks ago so 6 weeks to go until we can start prep for another fet. There’s part of me that is glad to be on a break. We have had 2 fets this year already so I feel we need it. And yes I had intralipids before my last fet. Will have them again next time .. who knows if they made any difference to me but sadly no change to outcome.

I see you’re pgta testing , really hope this route is helpful for you and that you’re doing ok in the wait to hear about them . I wish I had tested our embryos to begin with, but you never know the journey you’ll end up on.

@Hopeandfaith1990 thinking of you. It is so hard not to test as either way it totally shifts the reality you are in. Go with what you need right now and nothing else ❤️

@Hopeandfaith1990 they say it is about 2 weeks, so need to book back in with CRP and start on Hydroxy again before thinking about a transfer in October, providing that some come back genetically normal. Are you taking Steroids? just remember they mask most pregnancy symptoms. Also if your on progesterone too - can be confusing whats PMS and whats pregnancy.

@Holdinghope2025 where are you doing your IVF? would you go PGTA with this egg retrieval? are you also on steroids? it might make a difference with the hydroxy build up for the next FET.

Just had a call from the embryologist that another 7 have made it today at day 6. which is insane. So we have decided to pay for 10 to be biopsied as its £450 a pop. Hope i have made the right decision to not test all as it's just so much money.

Quick update from me (been away so will try to catch up with everything later).
just got results back from my blood assay and my immune system is still flared. I’m down to 5mg Pred today at 16 weeks but it looks like I am going to have to stay on the Pred for some time yet. Doc said it was a good job I had the test re-done. Bit worried tbh. Anyone else had to take it for longer?

Wow @Jecca88 that is AMAZING!! Yes, husband and I had agreed we’d cap at 10 if we got that far - obviously we only had 4 but that was our cap too cos it’s so expensive and you’d hope with those numbers you’d get at least a couple of euploids.

@Objectiontime sorry to hear it’s worrying you, remember the pred has got you this far which is amazing and you can continue to take it as long as you need. It’s so good you got that test done, can you do it again if you consider coming off again in the future? Xxx

9dp5dt and 3 x BFNs 😭 I’m absolutely devastated. Going to stop all medication and plan next steps.

So sorry @Hopeandfaith1990 . It is just so painful. It’s understandable you are devastated. Hope you can give yourself care and all the time you need to process ❤️

So very sorry to hear this, just rubbish news. Sending you the biggest virtual hug xx

Oh my love @Hopeandfaith1990 i am so sorry :( thinking of you.

Thanks all. I'm upset but okay. We just have to pick ourselves up, dust ourselves off and go again. I feel lucky to have 2 more embryos and I just hope the clinic allows me to go back to back with another transfer because I just want to focus on the future. Hope everyone's okay, love to all. xxx

@Hopeandfaith1990 So sorry to hear this devastating news, and hope you are getting good support from the clinic and everyone else around you. Wishing you all the best with the remaining two embryos.

@Objectiontime That's great that the pred has helped so much, and I hope you can stay on it as long as you need to. I had been thinking of you...

@Hopeandfaith1990 ahh fair enough my love and i too hope you can have another transfer. Try and relax for a few days and enjoy some wine and naughty food. You have such resilience remember that, no1 should have to endure what we do.

@Hopeandfaith1990 I am so so sorry, I'm so devastated, I was crossing everything so tightly for you. Allow yourself to be sad and angry, let it all out and then think to the future. Sending you the biggest hugs in the world 💕

@Hopeandfaith1990 I’m so sorry sweet it just sucks and isn’t fair. Been thinking of you xxx

Hi girls I can’t believe I am having to give this update it’s the most horrendous and unfair world that we live in. I lost my beautiful girl Hallie who was born sleeping after I suffered a near death placenta abruption at 35 weeks and 2 days. She was absolutely perfect In every single way and I just don’t know how I’m supposed to move through life anymore. 3 miscarriages and a still born how is this fair girls ??? How can I go through all this again!

This is the most awful news, I genuinely have no words. I can't begin to understand what you must be going through, but wanted you to know that my heart goes out to you and I'm sending you so much love. Nobody deserves to go through what you have.

@Meg310532 Meg, I am so so beyond sorry and heartbroken to read your update. There are truly no words. I can’t believe the world would be so horrifically cruel. Hallie is beautiful and I am sending you and your family all my love and thoughts. All she knew of this world was love and the safety of you. I’m so so sorry x

@Meg310532 There are just no words, life is so unbelievably cruel. I just want to give you the biggest hug in the whole world and to squeeze the pain away. Your little girl Hallie is absolutely gorgeous and she will be a treasure in your heart forever. Take time to grieve and we'll be here to support you when you feel ready. You've been through so much, you are so strong. Sending your family so much love 💗

Oh @Meg310532 im just so so sorry. There are no words to even start. You, your family and your little one I’m just so so sorry xxx

@Meg310532 I can’t find the words, im am soo devastated to read this, I never thought this would happen to you, How can this world be so fucking cruel. Hallie looks so precious and perfect, it’s just so unfair. I am here if you need anything and I know we have never met but I have always loved speaking with you and know you always rooted for me too. Heartbroken 💔

@Meg310532 I am just so very, very sorry p! This is the most awful news and, as others have said, there are no words to express. Hallie is a beautiful baby and will always be loved by you and your family. I am shedding tears for you all. Once again I question what sense there is in life. X