Immune/NK cells pred thread #34

[Hopeandfaith1990]

Hi all, started a new thread as the old one was full. Not sure if this is the way to do it but I've c&p'd the list of people on the previous one as much as poss:

Old thread here: https://www.mumsnet.com/talk/conception/5228367-immunenk-cells-pred-thread-33?page=40

@Jecca88
@Gizmo1983
@Deerdancer34
@Objectiontime
@SWMum9
@TammyinCork
@Newbeginnings22023
@Fletchasketch
@Morgan236
@CarpeDiem75
@ALittleLight
@MC8
@venusStarr
@Gizmo1983
@Carportforme
@Meg310532
@Newbeginnings22023
@recurrentmis
@hopefulH
@v60
@lozzmax
@fleur89
@motherofshihtzus
@sunflower360
@kea1990
@sprinkleofbabydust
@star2022
@rumandspinach
@ems123456789
@rainbowsunshine81
@mamaw05
@thornters
@elarcoiris

@Fletchasketch I’m so sorry, what a huge shock for you both. We’re here for you whenever you need and whatever you decide. I’ll be thinking of you and sending so much love and strength as you process it all. Xx

Oh my love @Fletchasketch as if you can take any more! This is so incredibly hard. I am so sorry to read this. Our last MC with CRP made it to 12 weeks to the day and we didn’t do the NIPT. Found out after genetics it was Down syndrome and realised that lots of babies with downs don’t make it to birth. It was heartbreaking and can’t even imagine if I would have known it and had to make all the decisions ahead. Take all the time in the world. We are here for you whenever you need us. I’m just so sorry. X

Hi all, hope everyone is okay. I'm doing my next FET this Saturday! I started Pred again on Sunday and WOW have I not missed that. Barely slept Sunday & Monday night - going to put myself to bed at 8pm tonight to try and get some hours back. If anyone has any reccos to help with this please throw them my way! I already take magnesium and use the magnesium sleep spray. Usually I take melotonin but trying to wean off ahead of the transfer. So tempted by chugging night nurse haha.

Also started Fragmin injections for the first time which are sore. I've got my GP to sign me off for a week next week, feels awful missing school but my anxiety is so bad I don't even think I'd be able to teach properly post-transfer.

How is everyone?

Sending love @Fletchasketch no need to reply but just know we're thinking of you xxx

@Fletchasketch praying for your heart darling….❤️‍🩹🫂

@Hopeandfaith1990 oh love hope it calms down, my first couple of days on it were awful too! Now I don’t really notice it but wake up super early and can’t seem to sleep past 6.30 anymore. I try to take the pred before 9am. Pillow mist, hydrating and essential oils too! How you feeling about the FET? I think that’s good you are having a week off - can’t even imagine having to teach with all that on my mind. Are you doing your usual routine? An egg a day? Mc Donald’s chips after transfer? Thinking of you lovely.

got my 8 1/2 week scan tomorrow with dr edge, i am basically having a scan a week now and my nerves are in tatters. I am so grateful I get pregnant so easily, but I honestly hate it - the anxiety is just so overwhelming. Mixed with hormones, meds, and just everything - I don’t know how I am still putting one foot in front of the other. Xx

Sending love for your scan today @Jecca88 , the anxiety is absolutely overwhelming, I empathise completely xx

Thanks angel @Jecca88 I actually got into bed at 8.30 last night and slept through to 5am, feeling like a new woman. Haha yes I am using my chart but I’m surprisingly blasé / chilled this time. I think cos I went so OTT last time and was so anal with the meds and everything yet it still didn’t work I’m a bit like 🤷‍♀️ who knows.

Can’t wait for those Maccies fries.

sending you all the love and luck for the scan today. I feel your words deeply. I am so ready and excited to be pregnant again but equally I know I will find it so anxiety inducing. It’s literally on your mind 24/7 isn’t it. I’m so impressed with you for keeping going, even if that’s all your feel you are doing it’s still commendable after everything you’ve been through. Xxx

Thank you @Gems2811 :) how are you doing my lovely?

@Hopeandfaith1990 glad you got some rest last night, 5am is still early, tbf. I woke up at 4am this morning and just lay awake for hours ruminating on what was going to happen today.

Luckily we had a good scan - saw a proper little baby on the scan today with a strong heartbeat and the sub chorionic bump is gone. Feeling hopeful but know i need to get through our biggest challenge of the NIPT in a couple of weeks :(

sending love to everyone.

Yay @Jecca88 that is so amazing - doubly so for the bump disappearing!! 🩷 keep putting oen foot in front of the other and take it minute by minute, it’s all you can do really. I hope the scan relief at least lasts a few days if not longer. Xxx

That's such good news @Jecca88 , and that the bump has gone too! So lovely to see the baby on the monitor, what a feeling!

I'm feeling better now thank you but it's been rougher than I expected to be honest. A couple of days after my procedure I had nearly 24 hours of excruiating contractions, 4-5 minutes apart and to the point that I had to moan through them, they were through the night and too painful to sleep through. I passed some tissue the next day and so I'm not sure if that's what was causing them or if this is even normal, EPU seemed to think it was. I'm hoping it's all over now and my HCG returns to zero soon xx

@Jecca88 What super news! Every day is a step forward in the right direction 💞

@Hopeandfaith1990 Best of luck for tomorrow 😘😘😘

@Gems2811 I'm sorry its been so rough for you, hopefully it's all over, so you can regroup and move forward 💗

Lots of love 💓

Hi all, so I am doing my last cycle of letrozole on Dr S immune plan… probably the last one as I don’t think I enjoy taking all these pills.. I used to be able to get pregnant but we have tried for 5months and nothing and heard that prednisone can stop implantation. So because it is my last cycle I was tempting to take the meds only from bfp (if it happens!) has anybody done it? Didn’t speak to the clinic but because it is the nhs I prefer not to say because I know they will say No lol. Thanks!

hi @CarpeDiem75I’m also interested to know - I’m going into cycle 9 and had nothing! (Though for me it takes me ages to fall pregnant). I haven’t done super ovulation yet as the timings haven’t worked out with travel etc. but might try in December. What are your next steps after this cycle? I’m in despair and wondering what to do if this doesn’t work out….

Thank you @Deerdancer34 🩷🩷

@Gems2811 so sorry you’ve had such a rough time of it. I once had a similar experience with the contractions in a MC, it was awful. I hope your HCG lowers quickly and you feel a sense of closure.

@CarpeDiem75 I don’t know how they’d ever prove that Pred impacts implantation, not saying that it doesn’t just how would they know. I came to this conclusion with Hydroxy although Pred is much more widely used. It’s used very commonly in IVF cycles now, so I feel like they must think it’s relatively safe. Do you usually fall pregnant quickly? If you do then there might be something in it, but for me 5 months is not a long time when I’m TTC, it takes me on average 5-6 months between pregnancies I think. Obviously everyone is different.

@pagey23 super ovulation sounds like a good idea, especially if it takes you a little longer to fall normally.

Hope everyone’s okay - I am once again PUPO. Transfer went very smoothly and I’m hoping/praying/wishing/crossing everything SO much that it works this time. Love to all. Xxx

Good luck @Hopeandfaith1990 , glad the transfer went smoothly xx

Hey all, so sorry just catching up with everything!

@Hopeandfaith1990 so glad to hear your transfer went well, and that you have this week off - I cannot imagine teaching throughout all this!! I have absolutely everything crossed for you this time ❤️

@Jecca88 that’s such brilliant news - one step closer! Keep taking each day as it comes.

@Gems2811 so sorry you’ve had such a horrible time of it, that sounds really painful and distressing. I haven’t heard of that happening after surgery, but I only have my personal experience to go on, so I’m glad EPU could reassure you it’s normal. What’s the next step for you, preg test in a couple of weeks? I really hope it all resolves quickly.

@CarpeDiem75 I’m sorry, that’s so frustrating. I don’t have any experience except to say my NHS RMC used to say to take pred from BFP, but only because that was when they could authorise it - they would have wanted me to take it earlier but weren’t allowed to. Under CRP I have taken it 1-2 days after ovulation.

@pagey23 also sorry you’ve been going through this! Superovulation sounds like a good idea. Have CRP said anything about it?

Love to everyone Xx

Hi love, it’s frustrating isn’t it. I am on the NHS protocol and advised to take the protocol from the day of a positive ovulation test…

I consulted with a private fertility specialist in London and we also recently came back from Greece where they both said to take from 3dpo.

This is my first month trying 3dpo and also post hysteroscopy, hycosy & laparoscopy and yesterday I got a positive test 🥹🥹 really hoping this one stays!

I haven’t been as active on here the last few weeks as life has felt heavy but this group has really been a comfort and help to me 💖

So pleased for you! Were you also on hydroxy? How long had you been off it?

Crossing everything for you lovely 🥰

Thank you!

I was on hydroxy but I’m convinced it messed up my cycle. When I was on it for 5 months I didn’t have a positive ovulation test and had irregular bleeding. I’ve stopped now and just on pred and aspirin x

Thank you my love, how are you feeling now?

@Hopeandfaith1990 You're PUPO💪 I'm crossing everything.🥰 What's your next step?

@SWMum9 Oh how lovely!!! I'll keep everything tightly crossed for you 😘

@pagey23 I think Superovulation may be a good next step for you perhaps? It took away a lot of stress for us. It can still take time though, so obviously there are the financial implications too.

@MC8 Hope you are recovering well 😘

I'm onto 3rd cycle of Superovulation... 🙏
Much love to you all 💓

@SWMum9 wow everything crossed for you! x

@SWMum9 ahhh... sending you all the luck, I really hope this your time!

@Hopeandfaith1990 @Deerdancer34 I'm doing well thanks, lucky to have recovered quickly from surgery. Haven't booked counselling yet as i've been quite busy and feeling ok in myself, but will do it soon.

@Deerdancer34 I have my fingers crossed for you this cycle xx

Hello all, just catching up here!

@Hopeandfaith1990Wishing you so well for the two-week wait! Fingers crossed!

@Jecca88Rooting for you!

@SWMum9: Congratulations, and wishing you all the luck!

@Gems2811 So sorry to hear things have been so hard for you. Wishing you very well for your next steps on this horrible journey we are on.

@CarpeDiem75 and @pagey23 I am in the same situation. First cycle with prednisolone and progesterone, I took from ovulation. Then second cycle, 3 DPO - and my period was three days late when it is usually bang on time! Am convinced that these meds are messing up my cycle. On this third cycle, I followed Dr Thum's advice, didn't take the meds at all and decided to wait for an early positive test. Tested at 10 DPO each time and still no pregnancy, whereas I used to get pregnant on first try before, even a month before turning 42 in May... Waiting for the IVF clinic to schedule us in their calendar (apparently I have a 3-week wait for this now - are the IVF clinics in London as slow as the ones here in Ireland?).

Hope everyone else is doing well!

Woman sues over claims fertility clinic ‘bootcamp’ made her have a stroke | The Independent

Any thoughts?