Immune/NK cells pred thread #34

[Hopeandfaith1990]

Hi all, started a new thread as the old one was full. Not sure if this is the way to do it but I've c&p'd the list of people on the previous one as much as poss:

Old thread here: https://www.mumsnet.com/talk/conception/5228367-immunenk-cells-pred-thread-33?page=40

@Jecca88
@Gizmo1983
@Deerdancer34
@Objectiontime
@SWMum9
@TammyinCork
@Newbeginnings22023
@Fletchasketch
@Morgan236
@CarpeDiem75
@ALittleLight
@MC8
@venusStarr
@Gizmo1983
@Carportforme
@Meg310532
@Newbeginnings22023
@recurrentmis
@hopefulH
@v60
@lozzmax
@fleur89
@motherofshihtzus
@sunflower360
@kea1990
@sprinkleofbabydust
@star2022
@rumandspinach
@ems123456789
@rainbowsunshine81
@mamaw05
@thornters
@elarcoiris

Isn’t it just. Feel like I can’t ever get the balance right. Hmmm I wonder if it could be the hydroxy??

we are going to IVF Serum. I haven’t had a hysterocopy however if they find anything on the scan in Greece they will do one the next day.

here is the fb group - www.facebook.com/share/g/16BdcyemFQ/?mibextid=wwXIfr

Oh @Hopeandfaith1990 how horribly confusing. I hate all the differing opinions and we're stuck in the middle not knowing what will work and what won't (the professionals prob don't know really either...). It's a bit concerning what she said about the Hydroxy...I'm on it this time but wasn't last time. What do you think you'll do, see what another consultant thinks? I hate this for you because now you're left feeling unsure of what to do. Sending you love ❤️

@SWMum9 Good luck in Greece!

@Hopeandfaith1990 I hope so re my friend but of course I so get where she is at but it is sad. Yes p, not sure about the pred thing. It's like you say, experts have so many different opinions on when to start taking it and I completely get the reasons Dr S has for wanting ladies to take it from ovulation. I just wonder, with my very early losses, before my immune tests and results, the pregnancies seemed to start okay and then failed at 5 weeks to the day, apart from my first MMC loss, so I wonder, if I had taken the pred from the day I got my positive tests, if it would have made the difference. Not sure if my doctor would have wanted me on pred from ovulation if I could have had the intralipids. Finding out I couldn't have them did seem to change his mind about when I should start the pred. Then there's our friend Gizmo, who didnt get her pred till after the positive test this time so it just goes to show I guess. Hydroxi was never mentioned to me, despite my doc saying my results were pretty dire. I hope you feel better without it and that it makes the difference for you. Xxx

Hi everyone! Just jumping in! In the same shoes. I am on complex protocol with prof. Shehata and waiting for my miracle.
@Objectiontime soo good to hear about your wonderful news! We have been speaking in the previous thread! Congratulations darling ❤️🙏🏽

Hi all, just booked my cycle 7 intralipid for next week… 🫩🫠 I decided against super ovulation this month as I’m quite busy at work and also come down with the flu so I’m not optimistic!! Next month should be better as I’ll be in Thailand when im ovulating. I only ever get pregnant when I’m on holiday!!

spoke to Geraldine on the phone and she mentioned that after 6 months of intralipids you are meant to take a 1 month break because of the pred. I didn’t know that - thankfully I did do that anyway but no one told me that - pretty poor from them… I thought I would flag though just in case others didn’t know that

hey ladies,

hope you're all well all things considering. Just returned from my trip to south italy and it was truly lovely to get away. Its hard to fully get into things and relax but it was nice to not be tracking and TTC for a week. I am still so triggered by all the family's on their holidays as I just can't wait to have that and still so scared that i may never have that. Had my catch up appointment with Kings regarding FET - so annoying but i need a nurses consultation before we can proceed and the earlier appointment is the 28th october :( so i am guessing we won't be doing a transfer in October. Just got to get my head around it as was so focused on getting back from holiday and cracking on.

@Hopeandfaith1990 that is so interesting about the consultant saying hydroxy effects implantation - i asked my consultant today and they said they can't prove either way. Are you going to talk to NHS clinic? let me know if you find any material too on this.

@Objectiontime congrats on the half way point, rooting for you. :)

Sorry to hear its been a long 6 months @pagey23 - that is mad they don't tell you that. Did you need to go back for another consultation after 3 months?

Hope all goes well in Greece @SWMum9

love to everyone i have missed

@Rainbowchaser87 thank you so much, that's really kind of you to say. I really hope you get your miracle soon hun xxx

@Rainbowchaser87 thank you so much, that's really kind of you to say. I really hope you get your miracle soon hun xxx

Thanks @SWMum9 I will join this weekend. Hope everything goes well in Greece - do update us if you want to, I'd be interested to hear how it compares to UK stuff.

@Deerdancer34 Thanks lovely, it is indeed! Just when you think you've cracked it with the protocol it feels like being back at square 1. I've stopped taking the Hydroxy for now. However, it has such a long 'half-life' (I find this concept so confusing lol) that it'll be in my system for a few months anyway.

@Objectiontime Yeah that's really interesting, and so much of the research is very limited when you look into the conditions of these studies - as is any research/study to do with pregnant women/being pregnant. Thank you for the well wishes!! I hope you're feeling ok xx

Hi @Rainbowchaser87 love the username, definitely chasing a rainbow here too :-) do you take Hydroxy?

Have an amazing time in Thailand @pagey23 I spent 3 years living there, miss it so much. Fingers crossed for a 'just relax and go on holiday' baby for you 😍

@Jecca88 glad you had a great holiday lovely. I feel you on the triggers. Recently I've been so annoyed by people saying 'it will happen' etc. because how the hell do you know?! I also feel you on the IVF admin/appointments. I have also been delayed a cycle because of this and it infuriated me lol. Where will you be in your cycle on the 28th? I badgered my clinic so they essentially let me do the consultation, nurse appt and paperwork appt on the same day so I could start ASAP last time.

I have been approved an NHS Hysteroscopy for October, so I will hopefully be transferring in November.

Hey everyone, sorry I've been so silent on this thread - I feel I've been retreating into myself over the last few months and finding it hard to keep up with everything, but I have been thinking of you all.

I can't remember where I left things, but in the Spring I had my first miscarriage under Dr S (8th total). Tests came back genetically normal, so I guess the only thing he could say was the protocol needed tweaking - they added in hydroxy and upped pred. from 20mg to 25mg. (I'd done 2 x rounds of Humira prior to starting)

I'm now on my 2nd cycle with this, got a negative test on 10dpo, but continued taking the meds that day anyway. 11dpo another negative test so stopped the meds. But then 12dpo (this morning) got a very faint positive.... so thinking of starting them again, keeping testing and contacting CRP on monday for intralipids if still positive?! What would you guys do?

This whole thing of being in constant limbo really messes with your head. We had decided to skip the next cycle if this was negative as my partner is away for the most of October and we've just both found it all so stressful....

It's SO confusing how different Drs have wildly differing opinions - and puts us in such a hard position wondering whether we are doing the right thing when we are already so vulnerable. When I was with the NHS recurrent miscarriage clinic my consultant completely refused to refer me to Tommy's as he disagreed so strongly with what they are doing - i never really go the reasons why, but I feel he was more aligned with Dr S's approach as my protocol with them was pred (10mg only), fragmin, progesterone & aspirin - all from the first date of positive test, although he said he would have wanted to start them earlier, but was unable to do so under NHS guidelines.

Sorry I haven't caught up with everyone individually, sending love to you all x

@MC8congrats on your positive! I really hope it all works out with you. I would go back on personally (but I’m no doctor!). I’m sure two days won’t hurt and gets you through until Monday when you can speak to the nurses. I always thought checking at 10 DPO was quite early myself and the months where I’m feeling more optimistic I want to carry on taking the meds, particularly progesterone! Good luck 😉

@pagey23 thank you. I've been here so many times before I don't know how to feel - but trying to stay calm and take it one day at a time. I think 10dpo is very early too, this is actually the only cycle I've done it then, the other times I've done 11dpo as the first day... taking it as 10 full days on the meds, and then testing. Really hope you have a lovely, relaxing holiday next month and that it brings you some luck in your next cycle. x

You are doing the right thing - someone asked earlier about accupuncture. It’s something I do regularly and you may want to do to try to keep you calm and support the pregnancy. Also looking into foods that could support might be helpful. You want to keep your body warm and hydrated so lots of soups and broths could help. Really hope this is your month!!

@MC8 gentle congratulations. I was where you were a few weeks ago and stayed on the medication and then retested with a digital two days later which was positive. I then had the intralipids about a week after that. Hoping that this is your time.

I'm now 6ish weeks and will be going in for my scan next week which I am frankly terrified of. I have slightly more symptoms than the previous times, so I am hoping that's a good sign, but who knows! As others have recommended, accupuncture has been great. No idea whether it is making any difference, but mentally it makes me feel so much better and the acupuncturist is so knowledgable.

@pagey23 thank you - I generally always feel the cold and am definitely noticing the change in seasons now so make sure to wrap up more! Thanks for the tip on acupuncture too, I'd done a few sessions earlier last year, but then had another miscarriage and sort of forgot about it. I did find it relaxing and liked the lady I went to though, so will reach out and hope she can fit me in sometime soon. @Fletchasketch gentle congratulations to you too... there's nothing I can say that will make the scan less scary, but I have everything crossed that this is your time too xx

@Jecca88 Stay strong 💪 I know how crap it is when you just want to get on with it all and you see all the families everywhere but keep determined, hopeful & ride high from your lovely holiday!

@Hopeandfaith1990 Gosh I literally know nothing about Hydroxy which is bad really! Will you try in October or wait until November?

@MC8 Definitely stay on the meds and see if the lines get darker 🙏. Everything tightly crossed for you!!

@Fletchasketch Very best of luck, which day is your scan? It's such a horrid wait isn't it. Really hoping it's your time 🥰

MC8, gentle congratulations from me too hun, I agree, best to stay on the meds . I too have everything crossed for you hun xx

@Fletchasketch Hope your scan goes well this week. I get the stress with them, I really do!!

@Deerdancer34 and @Objectiontime thanks for the good wishes. Scan was this afternoon and we heard a heartbeat for the first time ever. Measuring slightly ahead at 7w1 but know we're very much not out of the woods yet. I was an utter mess going in and Dr Edge was so lovely. Feeling huge relief at least temporarily today.

How is everyone else doing?

OHH my love @Fletchasketch what great news. Honestly it's the best feeling ever. Did you just burst into tears?

Thank you! I think I was pretty much hyperventilating and then when she put the sound on I just went to pieces. Genuinely the day I thought I'd never see.

How are you feeling this week?

Oh wow… that’s so amazing! Really happy for you and hope we all get to see that day! Put your feet up and rest tonight - it must have been an emotionally exhausting day for you

@MC8 gentle congrats, how are you doing now?

@Fletchasketch I am sooo beyond thrilled to hear you heard the heartbeat 🩷🩷🩷 absolutely amazing milestone. Made my day to hear this 🥰

@Fletchasketch that is such incredible news - i'm so, so happy for you.

@Hopeandfaith1990 thank you, I'm still testing positive today and going for intralipids tomorrow. One step at a time! How are you feeling about your hysteroscopy coming up? xx

Oh yay hope it goes well tomorrow 🩷 do you have many symptoms ?

feeling okay thanks - happy it’s going to be done under general, not had one before but apparently it’s quite unpleasant if you’re awake! Trying not to feel as if I’m ’behind Schedule’ knowing that IVF and TTC rarely goes or abides by any kind of schedule 🤣

@Fletchasketch Ohhh congratulations!! This has made my day, I am so so pleased for you! There really is nothing like hearing that heartbeat 💓 Soak it up! At one of the scans, I recorded it so I could listen to it, just a thought 🥰

@MC8 This is wonderful news! Lots of love for tomorrow!