Recurrent miscarriage and genetic findings- any success stories?

[vix_85]

We have just found out at 9+5 that our 5th consecutive pregnancy (no children) has been another missed miscarriage. D&C is booked for next week and after private fertility testing (because GP didn't seem to care), genetic issues is becoming the mostly likely cause. This will be tested next week with the removed materials.

Has anyone had this finding and had a successful pregnancy? How did you do it? How long was the process?

I am nearly 38, my heart is breaking and we are preparing for the worst next week, with being parents maybe off the schedule for us.

@elelm26 that is so lovely thanks so much for sharing your experience and positive news with your pregnancy. So sorry for all your losses 💔

Your story will help myself and @Unicorn2023 and others keep some faith in the difficult times for sure, so thank you for the hope.

Did you self prescribe the aspirin with progesterone or was it recommended by the miscarriage/fertility team?

Wishing you all the best with your pregnancy x

@vix_85 I took aspirin and progesterone with 2 other pregnancies but I didn't get past 7 weeks. I don't know whether this one is a "fluke" (I hate calling her that but you know what I mean) and we just got lucky or if there was some underlying reason and I'll probably never know!

I am a rare case though that I've had that many and no known cause so don't want to worry you and think it'll keep happening to you because likelihood is that it won't.

It hasn't come easy, I spent 2 months in a psychiatric hospital with my depression after a massive mental health collapse/mental breakdown when I was 27 and this was honestly our last attempt. We agreed that we wouldn't even go down the IVF route as we'd been through enough. I'll forever be grateful for this little girl 🩷

Good luck on your journey, keep in touch! I'd love to hear all about your success in TTC as I know it'll happen for you! Keep as positive as you possibly can and don't forget to take a break/a holiday/time for you if needed xx

Sorry I forgot to say that aspirin was recommended by dr so I bought that and took it continuously whilst TTC and progesterone is prescribed medication. Once they check the baby is in the right place (not ectopic) and has a heartbeat they can start giving it, I was 7 weeks when I started it x

So sorry you've been through so much @elm26 but so lovely to hear of your miracle baby girl on the way.

Thanks so much for your wishes and the information on the aspirin 🙏 ❤️ I was prescribed progesterone this time but didn't stick xx

Morning @Unicorn2023, how are you feeling today?

I had a really restless night feeling very 'empty', and thinking about how I'd feel if this is it for us. Trying to push those thoughts given the positive stories we've had on here but it's hard isn't it!

I feel there may be tears today with the sudden change in hormones x

Dear Op Sorry to hear about your MC.
I have had one with twins at 9 weeks, the hospital was going to do genetic testing but then said I needed three mcs to get one. I was doing ivf so I basically said to the ivf clinic that I wanted a genetic test and I had booked one at another clinic. They told me to carry on with the ivf, but I didn’t want to waste any embryos so insisted and they did the test. It came bk fine. You can book these tests in private clinics without any GP involvement. I think it was about 1.5k. Also in my treatment they gave me blood thinners and a bit of steroids, progesterone pessaries, oestrogen tablets etc. You might need a bit of help sustaining your pregnancies, without any help I couldn’t get past a chemical pregnancy. Check your thyroid level it should be below 2.5 otherwise you can have miscarriages. You might need a mot at a clinic and an Amh blood test. The structure and blood flow in your uterus could impact your ability to sustain a pregnancy. Because you are 38 you might need to pursue this privately if the nhs is a bit slow.

Thank you @Cherry2456 for replying with your experience. So sorry for your losses 💔.

We've actually been through private testing for the usual clotting, progesterone, lupus and egg quality as GP didn't move. So now, due to the 5th loss needing another d&c, the NHS have agreed to run the genetic testing and the surgeon made my referral yesterday to the NHS recurrent miscarriage clinic which is linked to the fertility team, as the GP hasn't made any progress on that despite my many requests.

Feels like the genetics is the next hurdles for us now as everything else has come back clear..x

When I did ivf in a uk clinic you have to use progesterone pessaries every day for 3 months. They give this to people on the continent when there is potential issues with the pregnancy, they are only catching on to this one here in the nhs. These are the things that they might or might not suggest at the recurrent miscarriage clinic. Also the private clinics use steroids the nhs not so much. So there are differences in protocols. I went private my friend went nhs. Sperm quality also affects ability to get pregnant was that tested? Good luck with the tests. In my experience Gps are useless/ negligent in this matter.

@Cherry2456 that's really helpful thank you. We'll see what the NHS come up with now as the surgeon yesterday was so supportive and recognised the lack of GP help. If there's hope for us at all, it's likely it'll have to be private IVF as my clock is ticking too quickly for NHS waiting lists for IVF.

My husbands soerm was tested and all good, so to date, it's been out down to bad luck by the private fertility MOT. For us no findings has been the most frustrating !x

@vix_85 Morning I’m ok bit less sore today ♥️
I felt exactly the same as you 😢 thought once it was over and done with I would be ok but I still have a bloated stomach and I just feel empty all the time plus feel like everyone on my Facebook is pregnant just now which isn’t helping 😫🤦🏼‍♀️ having the same thoughts too and our conversations have really helped but it is so hard to block it out 😢💔 Are you resting? I have lay on the couch for a week just watching sad films to try and get the tears away and sadness away it’s ok to cry it really helped me 🤗 sending you lots of hugs xx

@Unicorn2023 it does indeed feel like everyone else is pregnant (or moaning about their kids!). I've logged off from all socials which is doing wonders for my mental health; it comes highly recommended!

I'm also bloated and waiting for that and the inflated sore boobs to go away. A body reset but the hormone changes with that are not pleasant.

Definitely resting on the sofa watching the Ed Sheeran documentary and reading a bit. Soul and heart mending for sure ❤️ hope you're ok x

@vix_85 I never actually thought about doing that it’s a good idea because the more I see the worse I feel 🫶🏻

I know I wasn’t the skinniest anyway but I’ve stopped looking in the mirror just now feel like a whale 🐳 after effects are really not good 😫

oh I’ve not watched that yet let me know if it’s good 😊
I’m just feeling hopeless today and like you haven’t slept great for ages can’t switch off.
I have no motivation to do anything at all but move from bed to lie on the couch but I’m sure it will get better why is life so cruel we should be suffering like this 💔♥️🤗 xx

Hi, I just wanted to give you all a little hope. Firstly I am sorry your going through this I know how; with each MC, how much it breaks you. I have had 10 pregnancies; the first resulted in DD 19, then 2 MMC, DS 15 was then born, 5MMC followed over the last 3 years and have just had 2nd DS who is 7 weeks. After my 6th MMC I had genetic testing which showed that I am a carrier for trisomy 13; which the 7th MMC confirmed the cause of it not proceeding (I didn't find this out until after MMC 7) basically I was told out of 6 potential genetic make ups only 2 of them would be able to survive, the other 4 I would miscarry or in the unlikely event that I managed to carry would die shortly after birth or be still born. I had to have a NIPT (free on NHS due to genetic condition) at 10 weeks with my final pregnancy which thankfully did come back clear and he is absolutely perfect. I would definitely push for genetic screening and make sure the products of conception are tested as although I was distraught it was my "fault" we kept having MMC's I was more prepared although I found it very hard to get excited at all during my final successful pregnancy. Good luck to you all x

@Bbdm1984 so sorry to hear of all your losses, but so glad to hear your latest pregnancy was successful bringing your DS. Thanks so much for sharing your story; it certainly brings hope and will help me personally understand a bit more when we get our genetic results back I think. Thanks again x

Morning @vix_85 how are you feeling today? X

Morning @Unicorn2023 I'm less emotional today but had two bleeds during the night which were a bit triggering, but not to the level the hospital would be concerned about. Managed a shower/bath combo and feel so much nicer. How are you?x

@vix_85 The bleeding was a trigger for me too made me realise it was all over and that’s when I started feeling empty it’s a vicious circle isn’t it 😢💔 Glad your shower/bath helped keep a wee hot water bottle close by too that has helped me a lot. I’m doing not bad but still haven’t managed to go out I just don’t want to see anyone which I know is not good at all because all I do is think how life is so unfair for us I feel like less of a woman that I can’t do the simple thing thats meant to be natural for us it’s soul destroying sorry if I’ve made you feel worse I honestly don’t mean to just having a worse day than normal 🤗♥️ xx

@Unicorn2023 please don't apologise. This is going to be a rollercoaster which we've both unfortunately been on before. You made it through last time and you'll male it through this one. We both will. Why don't you try and make some mini goals for the next few days? Maybe tomorrow aim to get dressed in the morning and pop to a shop to get a Magazine and treats. One hurdle overcome and very briefly outside 😘 The next day maybe aim for a walk around the block to get some fresh air. Try and take a positive from each day; even getting dressed and out of bed is a positive and should be celebrated in this situation x

@vix_85 Thank you so much thats a great idea I will definitely do that ♥️ You are so right we will get through this you have no idea how much I needed to hear that 🤗 make sure you rest today sit watch tele and eat chocolate try not to do to much 😘 x

And the external 'advice' and 'suggestions' start. Desperately trying to keep my cool at comments like "looks like you'll need a surrogate", "my missus can carry babies, she might help", "no point being upset, you're ok".

I want to SCREAM at everyone as these comments are so hurtful. Particularly family writing off my body suggesting we start looking for a surrogate because they're disappointed. Sorry folks but maybe you'll have to suck it up and accept we may not give you grandchildren! That's not a guilt or pressure I should have to bear in my opinion. 😤🤯

@vix_85 OMG 😢 that is absolutely horrendous the sad fact is they think there suggestions are helpful but are they F**k (sorry for swearing) mine was least you know you can get pregnant and if I could carry it for you I would well woopy doo thank for that!
I wish people just wouldn’t say anything as if you don’t already feel bad enough without this. You would expect more from family but I’ve realised sometimes they can be worse with there comments they don’t help at all 😞😢

@Unicorn2023 I think they mean well but sometimes it's hard to dissect their true intentions.

I think I've come to the decision that unless it's my body doing this, it won't be happening. I know people have huge success with adoption and surrogacy but I really doubt my connection unless I've carried it. My husband is not up for adoption due to the same reasons.

I've already got my referral booking call for Wednesday so the surgeon did what he promised and I couldn't be more grateful.

I hope you're doing ok today and that you've got your shop visit planned x

I can also recommend CRP clinic in Epsom.

I had several miscarriages with no explanation. NHS weren't able to do very much.

A friend recommended CRP clinic and I now have two children.

I had some type of killer cell issue. Every pregnancy was viewed by my body as an infection and terminated. I had a huge concoction of medication and treatments but we now have a 3 & 5 year old.

I'm so sorry for your situation, I remember how heartbreaking it was. Wishing you all the best x

I’m so sorry you are going through this. It’s pretty unlikely you’ve had 5 consecutive pregnancies with genetic issues. We got fobbed off with this until MC 4 was tested and was normal genetically. NHS recurrent miscarriage testing proved unhelpful but I was monitored and scanned in future pregnancy. We were actually helped by Prof Siobhan Quenby at Coventry university hospital and had a successful pregnancy first time after a diagnosis of high uNK cells. All my losses were around 10-11 weeks.

@vix_85 I agree they do mean well but it’s too raw just now to take anything in a nice way 😢
I’m in the same boat my fiancé said the same about adoption and if they come back with the genetics 🧬 I’ve decided that it for us. That’s amazing and was so quick 🤞🏻♥️ I will need to phone them I’ve heard nothing since I left the hospital last Wednesday 🤷🏼‍♀️ I’m just drying my hair just now I’m dreading it already but I need to do this or I don’t think I’ll ever go out again xx