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Immune/NK cells pred thread #31

983 replies

VenusStarr · 13/04/2023 09:05

Hi all, we've fill up the last thread, so starting a new one. Will start tagging but feel free to add anyone I miss!

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HopefulH · 28/06/2023 08:40

@VenusStarr yes they've put me on 150iu Gonal-f per day next cycle plus 5mg Letrozole... I'm not feeling great about it all. I'll also be on progynova.

I responded better on 7.5mg letrozole so I'm confused why things have escalated to be honest. I think I'll email the nurses and ask what the idea is. I'm worried that this aggressive approach is just getting lower quality eggs and isn't suiting my body. I don't seem to be doing anything myself anymore like my hormones are so messed up.

I'm triggering this morning but my LH tests have been so low still so my body clearly hasn't started to ramp up to ovulate what is supposed to be a ready follicle in there! Feeling very disillusioned with CRP to be honest and the SO crap. I feel it's taken away my ability to ovulate on my own and I'm not getting pregnant doing it their way either. Dr S is not very easy to talk to either so when I'm in there I always feel like everything he's suggesting is fine - and then I come away with a load of doubts and questions I won't get answers for.

How did you get on on Gonal-f? Did you get more follicles/better response?

It's so expensive I'm just not sure how I feel about going down that route. I know they are trying to find the perfect combo to get 2-3 follicles plus a good lining - but I don't think my body is going to do this consistently because I have such low AMH and AFC. But - all of my pregnancies previously have been natural or my last one was on 2.5mg Letrozole when I actually produced the most follicles to date.

Sorry I'm rambling. I didn't sleep well last night and have woken up in a bit of a state about it all. I just want my body to work again! But I really do think my gut is telling me all these meds are not for me. But going against what CRP want me to do is scary...

I'm not sure what to do next cycle as I'll also be on holiday. I suggested a break to Dr S and he said this wasn't a good idea as the statistics on success is based on consecutive cycles... still - I'm tempted to do low dose Letrozole and see if I ovulate naturally the old fashioned way and then take the steroids. And just miss the intralipids... anyone done this before?

Sorry again for the ramble x

VenusStarr · 28/06/2023 11:27

@HopefulH I didn't end up with the gonal f in the end, I struggled to get hold ot it, then dh was poorly and so we just decided to go with 7.5mg of the letrozole and I had 2 follicles and over 7mm lining so it was ok. But bfn. So Dr E said she was happy to try that again.

I'm with you, I think not being on hormones back to back helped my body. If I have too many meds, I think my body does the reverse!

It's really hard to know what to do for the best and it can feel like they disregard concerns. I think if you want a break, take it. Are your cycles usually regular? It might be nice to have a holiday and not take tablets and pessaries for a bit? Do you ovulate on your own? I'd be tempted to not do letrozole as well (only because my lining really hates it without estrogen) but you could still take steroids with you?

Sending a hug 🫂 I just wish things were simple for us ❤️

@star2022 my dh is always saying why are you paying so much money if you think you know better! 🙃 but at the same time he just thinks we're wasting money... glad you're on the letrozole, how many follicles do you usually get? I wonder if the trigger got the smaller follicle, so that's why it was delayed?what cycle day was your scan again, 30mm is big.

I think af is due by next Thursday (judging by last cycle, it could even be by Monday?) I'm worried I'm not ovulating on my own. My resting heart rate is very low. I've randomly checked my bbt on a couple of days and it is my usual post-ov temp of around 36.65 though 🤷🏻‍♀️

We've settled our remortgage which was stressful. We'd wanted extra cash to do some home renovation but it was too complicated. So we're taking money out of the ivf pot 🫠😬 I feel ok about it. But its also weird that I feel OK about it. Feel like maybe we're coming to the end now, like I don't want to just keep throwing money at it.

Hope everyone is ok ❤️

OP posts:
Lily1990 · 29/06/2023 22:21

Hey all, sorry I have been quiet, work has been busy and not much to report my end! I have my first intralipid infusion next week and then will track ovulation and start the pred (15mg, which he decreased from 25mg so hopefully side effects aren’t too bad but it still works!). Not sure if I already updated you all but DP got his sperm frag results back and was normal, so the problem is totally me! But I guess I should be glad we don’t also have issues on his end.

Dr S tried to put me on the superovulation plan as I ovulate really late (last month CD29) but I said no (for now) because we’ve conceived 4 times and never during the 3 letrozole cycles we did previously at the Evewell. And it’s super expensive and I think the trigger forces me to ovulate before my egg is at peak size to be released naturally (which I worked out happens when it’s bigger than when they make me trigger). I also find it interesting reading comments here because at the Evewell, they refused to give me more than 2.5mg letrozole for fears of hyper stimulation, but Dr S seems to give really high dosages and aim for multiple follicles.

@HopefulH i can totally see why you want a break. Seems similar to me in that your pregnancies have been natural or on a low dose. Maybe worth trying without and saving some money for a month, especially if you’re on holiday? Might be nice psychologically too not to have the commitment and travel?

@VenusStarr well done on sorting your mortgage, I hope your interest rates are not too awful (we will have to do the same in a few months and dreading it). Have you tried this month? I hope your DH is doing well too.

Lots of love ❤️

Deerdancer34 · 30/06/2023 09:47

Well I've had one of the most traumatic weeks of my life really... EPU Monday confirmed an ectopic pregnancy, at that point I was hopeful I could miscarry naturally because my hcg had come down on last blood test. They rang me Tues morning saying hcg had gone up and they want me to come in to hospital to operate. It was the most surreal experience as I've never actually had to go to hospital on a ward before so it was all quite a lot to get my head around. 3 consultants told me an operation to remove tube with ectopic in it would be best, I emailed CRP and Dr Edge said I should take drug first. Never been so confused in my life and had to make a decision quickly, quite a huge decision to make when I was shocked by it being an ectopic, being in hospital & possibly facing surgery - it all happened so fast. The NHS staff were fabulous though. I was about to be taken for surgery but they knew I wasn't sure, so doc spoke to me again and then emergency after emergency meant I had to stay in overnight. I woke up with cold feet and although doc said removing a tube wouldn't affect my fertility, it felt wrong to remove it when I have no children & this would be my 4th loss and Dr Edge said it would affect fertility. Anyway I finally opted for the drug, so hoping my tube won't rupture now. Felt wrong to go against medical advice but so pleased I've come home complete...I'd rather my other miscarriages over this. The emotional roller-coaster of being pregnant & getting past the time I normally miscarry to having PUL, to it being an ectopic, to being in hospital about to have surgery....exhausted. Sorry for my long post which isn't relevant to CRP but I found it quite traumatising & it helps to off-load a bit, a lot to process still....

@star2022 @HopefulH @VenusStarr This had been my 3rd Superovulation cycle. 1st cycle I had 3 follicles, last 2 cycles, 1 large dominant follicle. I am a bit concerned that this big follicle is reason for ectopic but maybe just really bad luck. I'm going to be nervous when I get started up again....Its so hard working out cycles & when to go for scan. I went from ovulating on CD17 to CD13 on letrozole, so really my scan needed to be far earlier. No idea what my cycles will be like now with all this, will have to work it all out again. Annoying SO doesn't always work how it should... I am worried hearing that increasing the dosage doesn't necessarily help....what can we do though, they are the experts, they should know but I suppose they can't predict how each body will react. Wish it was simple....

Lots of love to you all and sorry for my big ramble!

Ems123456789 · 30/06/2023 15:41

@Deerdancer34 i am so sorry to hear about your ectopic, did you take methotrexate? I hope you are home and recovering now.

I had an ectopic last year and exactly like you wanted to (and did) keep my tube but it was such a rollercoaster. I was told my ivf cycle had failed, then found out I was pregnant, but my HCG plateaued and they said I’d miscarry, never happened and kept having positive tests, ivf clinic said it was just taken a while to leave but I felt really sick. 4 scans later in EPU and me demanding that I just didn’t feel right and they finally found the ectopic and I was given 45 mins and a walk round the car park to decide if I wanted to go straight into theatre or have the methotrexate. The whole process took about 5 weeks and it was such a mess!

sending my thoughts to you! Take it easy as methotrexate can really wipe you out 💖

Trgf55 · 30/06/2023 20:22

Hi all

I haven't posted on here for a while but just had a very quick scan and wanted to give some hope regarding ectopic pregnancies. @Deerdancer34 i had an ectopic pregnancy earlyl ast year, 8 weeks after a missed miscarraige. I unfortunately did have to have surgery to have my tube removed and i was so terrified it would affect my fertility. If it hadnt of been for super ovulation at the clinic i wouldn't have fallen pregnant as i was only ovulating on my tubeless side but the letrozole stimulated my ovary with my remaining tube. Please dont lose hope, ectopic pregnancies are traumatic and awful but there can be good outcomes afterwards. Take care of yourself and focus on recovering, it's a big thing.

Also for those of you questioning the letrozole doses, the month i fell pregnant Dr S upped my dosage to 10mg. I had 4 dominant follicles and one of them ended up being my little boy :-) i was also worried it was too high a dose but it worked out for me.

Sending love to all of you going through this journey. It never gets easier and it really does show how strong we all are to persevere. ❤️

Deerdancer34 · 01/07/2023 22:09

@Ems123456789 Yes on the Methotrexate and it really does wipe you out! But I'm just pleased I'm not in too much pain, I was expecting it to be really awful but I must have just been reading bad stories.... 45mins!? Goodness, it's not long enough to make such an important decision really is it!? Especially when you're in shock from being told its an ectopic. You must have been so relieved when it was all over. I'm so impatient to know how long it'll take to get back to normal and to get started trying again...did you wait the full 3 months?

@Trgf55 Thank you so much your story, its exactly what I need right now, that feeling of hope! Got to keep believing it will happen! And it's really reassuring to hear about your experience with letrozole.

Thank you ladies 💗

Ems123456789 · 02/07/2023 06:50

@Deerdancer34 yes it’s a strange drug. I just found it really wiped my energy for about 10 days. So I would recommend resting as much as possible. It will come back!
I did indeed wait the full 3 months when it came to ttc, I’ve been doing ivf so I felt like I needed to really get back to full health before starting another round.

HopefulH · 03/07/2023 07:47

Genuinely concerned how I'll ever get pregnant whilst on steroids... they make me feel so wired and I don't sleep! Averaging 5 hours sleep... any positive stories of others who find the steroids make them feel like they're loosing their mind but have still managed to get pregnant? Feeling so on edge this morning! Day 5 of 10 taking them! Also didn't help that my husband was snoring so loudly last night... I had some very angry feelings towards him which is also not like me!

@Trgf55 thanks for the encouragement re high doses of Letrozole! It's a relief sometimes to come on here and see some positive outcomes because when you're in the middle of it all it can feel so hopeless sometimes.

@Deerdancer34 I'm so sorry to hear of your ectopic. Sounds incredibly traumatic and so much to take in in such a short amount of time. Have you got any counselling support etc.? I have always found it's once things have calmed down that I really struggle, because I think when you're in the moment and having to deal with physical things the mental side takes a back seat for some time - and then it all lands! So yes, hope you have plenty of support and recover quickly from the meds!

Happy Monday all 😊 Here's to another week feeling hormonal as hell and roided up. Hope everyone is okay x

Ems123456789 · 03/07/2023 08:24

@HopefulH I am hesitant to recommend drugs to someone so I would recommend checking with your doctor first but I find melatonin tablets counteract the impact of steroids for me. (Well they did the last few weeks anyway). I’ve just had a frozen transfer on Friday so I have stopped taking it now and I’m still taking the steroids. Though I’m not on 3 lots of progesterone a day and I think that’s helping me sleep okay.

I also know some people find after a few weeks the effects of the steroids settle. Bloody annoying tablets to take though!

Newbeginnings22023 · 03/07/2023 09:11

Hi @Deerdancer34 so sorry to hear about your ectopic. I hope you have support around you during this difficult time.

Hi @VenusStarr thanks for checking in. I now have an appointment with my fertility doctor next Wednesday to discuss a new IVF cycle, then my appointment with Dr S on the 31st to discuss next steps without Humira. I hope he’ll be flexible enough and have an alternative plan for me. All being well my plan is to commence my new IVF cycle around September/October time. I won’t have time to try SO now due to Dr S being away in July then I’m taking time off in August. Hope you’re doing ok and your DH too.

Hope everyone is doing ok. It’s lovely stories from people like @Trgf55 that keep us going xx

MamaW05 · 03/07/2023 17:42

Hi all

I’ve lurked a while on similar threads but have now just suffered our third loss and looking for some advice from those who are in a similar position maybe further on in their journeys.

we’ve had 3 losses in the last year - 7.5w (missed til 12 week scan), 8.5w (missed til 12w scan, hb seen at 8 weeks, confirmed as Turners), 6w (missed til 8w scan, no hb seen at 6w scan, sent for testing). I would also mention that my first pregnancy in 2020 was successful, just high bp at the end, and I am very lucky to have an almost 3 year old.

for the most recent loss I was on heparin as testing showed I have factors making me more susceptible to clotting. I was also on progesterone from 4dpo and baby aspirin from 6w.

In my mind, if this failed my next step was immunes. However, my husband is very data driven and because of course no one researches women’s health all he sees is large official bodies saying it’s unproven and not safe, specifically steroids. Having been on these forums a while I believe the risk is very minimal, but does anyone have any research/studies/clarification from a professional that I could share with him? I can’t find anything concerning safety online. I am with St Mary’s who don’t believe in immunes and I think if baby is abnormal they and my husband will say try again with current protocol. I get the logic that we won’t have been able to see if blood thinners worked but I am scared it’s another try and if it doesn’t work we will only end up going to immunes anyway. I also have a low AMH so I worry about time.

I also have silent endo so planning on asking about maybe a lap to investigate extent of it. Other than that I believe I’ve had all other tests!

any insight appreciated!

thank you x

HopefulH · 03/07/2023 18:09

Hi @MamaW05. Very sorry you've had a third loss.

I think if you know you have endometriosis this is definitely something worth looking into - as I've read so much that links immune irregularities and endo. It's a chronic inflammatory condition so makes sense the bodies immune response might go into overdrive. I'm currently looking down this path now - but am also on an immune protocol with Dr Shehata.

I think to have three losses in a row, and all missed miscarriages (same as me) there has to be something going on besides genetics. That's what my gut is telling me - but I've never had any genetic testing done on my babies - just karotyping which came back all clear. I also had a successful first pregnancy but my little one was born very small.

Have you listened to the podcast episode featuring Dr Shehata on Audible - I think it's called the fertility method. Might be worth getting hubby to take a listen?

As you say, there is limited research out there due to the difficulty of carrying out such research on pregnant women. But Dr Shehatas results speak for themselves and I believe world-wide immune treatment is more common. We are so limited here by the NHS!

Is your husband concerned for your safety or safety of baby?

Hope you manage to persuade him to looking into immunes, if that's what you want. It's so difficult when you are not on the same page as your other half so I feel for you! X

MamaW05 · 03/07/2023 18:35

@HopefulH thank you for the quick reply!

Thats how I felt after my second as it was so similar to my first. I was very surprised when it came back as Turners. If this one is also abnormal I don’t know what to think. My current consultant told us that of women who have 3 losses in a row, for 33% of them they will all have been abnormal. I do also so far get pregnant fairly quickly so wonder if I just accept anything.

I have listened to this podcast and I see Rachel at the Fertility Suite :) Unfortunately I don’t think he will take much from it as it is from someone offering the treatment. He is looking for unbiased research. I may try and get us along to a consult at least so he can ask questions. I’m not sure if we would go with Dr S as it’s scary to let go of heparin when I’ve been told I need that but his results are good!

I think my partner is primarily worried about affect on baby. He’s read it can lead to defects (all I’ve found is very small risk of cleft palate) and our consultant said Autism which I have found 0 evidence of! Husband also said something about suppressing my fertility…no idea where that came from, I think to do with people not 100% knowing the ideal level.

Are you planning on doing anything different for your endo (like a lap?), or have you been told the immune protocol will take care of it? I’ve also been told it can affect egg quality.

So confusing having to make all these choices for ourselves.

Zest11 · 04/07/2023 22:24

Hi all, sorry I've been quiet. I've been taking a break from things. But I have been triggered. My best friend recently announced she's pregnant with number 2. She struggled with miscarriages before having number 1 so I am relieved she didn't have to go through it all again. But it hurts, it's really upsetting that she's pregnant again and I'm not and we've been trying way longer than she has (even though conceiving was never her problem).

I've been reading your posts about letrozole and super o. What is it that Dr s does? What day cycle do you start on and how long do you take it for? How does he decide your dose? What dose do you take? I dunno whether to just have a go with that. But saying that I have made no effort to order any meds that Dr s recommended after the failed ivf cycle. Tbh, I felt pretty disheartened when his plan didn't work for me and am still undecided about next steps.

@star2022 I remember a while back you mentioned dhea. I got mine tested at a Nuffield hospital and it was 3 something so lower end of normal and I got some biovea supplements online. Not sure what they're doing to my hormones, something, as I'm getting a bit spotty and libido has increased! I asked Dr s about dhea and he said the research doesn't seem to suggest a higher live birth rate (but higher eggs retrieved and pregnancy rates) but then he said it wouldn't do any harm. But he didn't recommend a dose o anything. I thought I would share with you as I remember you looking into it. I hope you are settling into your house okay.

Trgf55 · 04/07/2023 22:51

@HopefulH the steroids also made me suffer from terrible insomnia. I took them for 16 weeks in total I think (including weaning off) and my day would start at 4/5am. It's tough but hang on in there. The worst is the moon face lol but luckily that kicked in for me when I only had a few weeks left of taking them. I had to renew my driving license at that time so now i have a lovely reminder for 10 years of my moon face 😂

Just remember its all for what you want most though. I really did find the medication side of things difficult esp the progesterone. You can do it 💪🏼 xx

star2022 · 05/07/2023 11:45

@Zest11 Hey nice to hear from you! I'm so sorry about hearing about your friend, I can really sympathise with that feeling as my best friend also has had 2 kids now (got pregnant first time trying too both times!) even though we've been trying for longer than her and still waiting for our first. It really is a kick in the teeth and really difficult to come to terms with. Your feelings are totally valid.

What had dr s suggested for you to try next time? Do you have any embryos left? Is IVF still another option for you or are you a bit fed with it at the moment and want to try SO?

So when I went to see him initially, he did say he doesn't see why we can't get pregnant with superovulation as tubes are open etc but to give it 6 months. Usually there is 80% success between 4-6th month as it can sometimes take time tweaking dosages of meds and trying to get the scans on the right days/trigger. Fortunately for me, I've responded well to 5mg letrozole (which I think they just start you on to see how you respond) With 5mg, I've managed to get 2 dominant follicles each month and my lining has been perfect each time. However, I'm now on SO 4 so its getting a bit tiring now knowing that it always looks perfect but somehow still not working, but i'm still hopeful that we're now in the 4-6th month window so keeping our fingers crossed. I take Letrozole from days 2-6 of period, I then book a scan between days 7-9 as thats my window they've told me to book, I usually end up having the trigger shot at the clinic as my follicles are pretty dominant by then, I have intralipids on the same scan day, and then 2 days later I start Cylogest and steroids, test on 10dpo and stop meds if not pregnant and then repeat. I had my scan yesterday and had 2 follicles and trigger there and then, but have been told to increase it to 7.5mg if this cycle doesn't work to try and maybe get 3 follicles next time.

I also didn't know CRP now do IVF cycles. Dr Edge told me yesterday that this is an option after 6months of SO. They work with Kings fertility and they offer the whole IVF cycle with immune meds - Mr Jan at CRP looks after you. They also offer a discount for those who have had 3 consecutive superovulation cycles which is good to know.

And thank you for the info regarding DHEA, I do need to look into it but not sure if I can take it with steroids? Did he mention anything like that to you? I do think I need it as my libido is at 0, and I think I was going to take 25-50mg how much are you taking? x

VenusStarr · 05/07/2023 18:01

Hi everyone. I need to catch up properly. I just wanted to say I am so sorry to hear your pregnancy was ectopic @Deerdancer34 ❤️ that sounds like you had a difficult time. Sending you love.

@Zest11 I'm sorry you're feeling this way. I'm increasingly resentful of people who just seem to have an easy time of things. I avoided a bunch of friends over the weekend, they're all parents and one made a joke about being allowed to come if she was childfree that weekend... 😒 I just can't deal with people right now.
My superovulation dose is 7.5mg, only trued that dose so far. My amh is on the low side, plus my age, I got 2 follicles last time on that

@star2022 I hope you're OK. Fingers crossed for this cycle. It's hard not to feel despondent. I did look into ivf there but the travel would be tough and staying down isn't really an option. Plus I think they'd do high dose stims and I'm not sure my body would like that.

Dh has another op on Monday and he's been really poorly, thinking infection, high temp and high heartrate and feverish.it never rains but it bloody pours. Af is due tomorrow... our 6th baby's due date 😪💔 she'd have been one. Just feel like the world is against us and its just relentless. Will be back later, just off to sweat out all my sadness at zumba... (I did eat 4 hob nobs just before I came) sigh xx

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Zest11 · 05/07/2023 20:40

@star2022 thank you for that, very helpful! AHH I hope this cycle goes well for you. I hope the 4-6month time doesn't put too much pressure on you! IVF is still an option for us, we have a couple of embryos but I'm not convinced on their quality. But I expect they will get used at some point. But not now, I'm fed up with all of it. And yes, CRP do IVF alongside kings. After the IVF fail he suggested I add hydroxy to the mix on an empirical basis or just try again on the same plan. Tbh, he has been pretty honest in saying it's hard to know and I sort of went to him in the first place thinking "I wonder if it's the immunes" but he said he doesn't know. Re the dhea I don't know re steroids actually. He didn't say it would be a problem but he didn't really say much about it tbh.

@VenusStarr I'm sorry with how you're feeling. Are you doing anything tomorrow or are you just going to try and get through the day? I really hope Zumba lifts your mood a bit! I can totally relate to you avoiding friends. I have actually considered never meeting up with my friend again!! Brutal or what!! (Although we do live far away so it isn't impossible!) Thank you for explaining your dose etc. What concerns you about high stimms? I was on high stimms. My amh is around 3. :( I did manage to get 9 eggs, 3 blasts but I def do think the issue is egg quality for me with that low amh so I don't think there's much I can do. Hence why I am wondering if I give letrozole a go and aim for more follicles. But then that could be like going backwards as I did 3 iuis 5 years ago and none of them worked. So realistically I think things are coming to the end for us.

VenusStarr · 05/07/2023 22:12

Thank you @Zest11 just trying to get through the day 😪 just can't believe what's been happening this year and to reach this milestone and have not been pregnant in 18 months, just feels like a lot and like the universe is trying to tell us to stop bothering. Been feeling on the verge of tears all evening. No one will remember or know. I don't feel like af is even due, weird how last cycle it came unexpectedly. Part of me is wondering about whether it's perimenopause...

I'm just scared of high dose stims. My amh was 5 in 2020, christ knows what it is now, too scared to check. So I did mild ivf and got 3 top quality embryos. I'm happy on 7.5mg of letrozole. I would do injectable gonal f as a trial, rather than higher dose. My lining doesn't really like letrozole anyway but seems to respond OK to stims. When I tried all my FETs last year they kept putting me on more and more estrogen and my body rejected it and my lining regressed. But low dose stims got my lining up well in good time, so I kind of feel that using my body's own levels but just boosting a bit is the way to go.
I'm sorry you feel you're coming to the end as well ❤️ I just don't have hope anymore and I'm tired. Tired of putting us through it, tired of the same outcomes each time. It's shit.

I keep bloody dreaming about babies as well, this last week most nights there's been a baby in my dreams.

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comingsoon786110 · 06/07/2023 07:25

Hi everyone 🩵🧡

I hope all is well.

Apologies for being super quiet on here. Hubby and I have just purchased our first property together and have been super busy with the move- it's literally taken over our lives.

I have a zoom appt with RMC on the 18th of this month to discuss the biopsy results that I had done during my hysterscopy in June. We will be discussing what comes next but I am pretty sure they're not going to have much plans for me. I have an appt scheduled with Dr S on 02/08/2023 for what his next plans are for me so might be trying again from next month, let's see. I am going to start taking my hydroxy again from today so its in my system at least 6 weeks before we start trying.

I have been doing some research on tacrolimus and apparently its not safe at all during pregnancy. I know that's the case for all the medication he prescribes but this one in particular seems to have a lot of precautions which is worrying me as this is probably the next step in our treatment plan.

How is everyone else doing? I have a lot of posts to catch up today. First day back in the office today for me as well since the move!

nottsgdns · 06/07/2023 10:36

@VenusStarr Hey your sadness is really coming through stronger than I've seen it before from all your previous msgs. I hope you are OK. You've mentioned a few times you might be nearing the end of trying, which is where I am, and I really sympathise especially when you're dreaming of babies. I keep "testing myself" and holding friends' babies to check whether I still really REALLY want one or whether the need is wearing off. Coming off the meds has made me less manic about it all, I hope that is helping for you.

VenusStarr · 07/07/2023 06:35

@nottsgdns ❤️ it hit me like a tidal wave. Yesterday was hard, I cried a lot. My period decided to hold off until 5am this morning, woke up with cramps and can't sleep. So we'll try superovulation this cycle.
I'm sorry you're in a similar position, feeling you're nearing the end, you just feel helpless. And question everything - do I even want a baby? Hope you're ok x

@comingsoon786110 thats great news about your house, congratulations 🙂 sounds good that you have some appointments in.

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comingsoon786110 · 10/07/2023 21:49

Thank you @VenusStarr.
Hope you're doing okay 🥰🥰

Has anyone had/ know anyone who has had tacrolimus and had a successful pregnancy?

VenusStarr · 11/07/2023 07:08

@StillTrying10000 used it and has a little girl (hope you're doing ok ❤️) @comingsoon786110 has Dr S suggested it next time? I know its quite intense and you have to have regular monitoring.

How's everyone getting on? @star2022 hope you're superovulation cycle is going well. I'm due for a scan next week. I already feel like somethings going on in my ovaries but I also know my body tricks me. Delaying taking estrogen until I've finished letrozole. I seem to crash early evening but then have crap sleep. Am waking at 5 most days and not dropping off again.

Both dh and I got really stressed over the weekend, it was horrible. Can't remember if i said but he had his final op last week and got an infection. His bloods are also still showing poor liver function. Terrified ehat that might mean. Plus my cat had to see the emergency vet last night 🤑 she's got cystitis poor thing. Ready for the universe to stop shitting on us now...

Love to all xx

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