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Conception

When's the best time to get pregnant? Use our interactive ovulation calculator to work out when you're most fertile and most likely to conceive.

Immune/NK cells - pred thread 29

1000 replies

StillTrying10000 · 19/02/2022 20:14

Starting a new thread as the last was full.

OP posts:
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6
myrainbowjourney · 15/03/2022 19:09

@Trytryandtryagain11 it does! I think it's hard, but try to remember with super ov, they are telling you when you'll ovulate, so we shouldn't need to track. I'm terrible for not listening and thinking they might be wrong and what if I ovulate on my own etc. but I do think it's much easier to just trust the process if you can. We are here if you ever need to talk through it all xxxx

taffeta00 · 15/03/2022 21:40

Ladies, this has helped me too - was completely stressing myself out last week about whether Mr S’s predictions weee accurate and if I should be relying on my usual tracking ie kits and temps. Thanks for the common sense talk. Thank heavens for your support. Totally empathise with what you said about this being so isolating..I don’t want to go out as not drinking/ on the meds, am not comfortable discussing all the meds with friends who do t get it and it just becomes easier to shut yourself off. Hugs xx

Trytryandtryagain11 · 15/03/2022 23:15

@taffeta00 @myrainbowjourney as it's horrible we are all going through this but also nice not to be so alone! Literally all my friends are fertile-myrtle it would seem so whilst they are lovely, there's only so much they can understand (and so much pity I can take)

Have you done a few cycles of super-ov already or is it fairly early doors for you guys too? xxx

89Hope · 16/03/2022 07:54

Hi all,

I wasn't tagged in this new thread so have just caught up on 6 pages of messages in the last hour!! I thought it was a bit quiet on the old one!! 🙈

So sorry everyone has been going through various struggles over the last few weeks. It's so up and down, and I'm praying for us all that our luck turns soon.
I got ANOTHER puppy to help cope! I live 5 mins from the epsom clinic so if anyone needs puppy cuddles to cheer you up then just message me!

Our super ovulation has been a bit of a shitshow so far. One follicle on cycle 1, upped letrozole to 7.5mg and then no dominant follicles! They said I may have ovulated early but no sign on the scan. Took an ovulation test when I got home and it was positive but clinic advised to take trigger the following week (as small follicle may get to a big enough size). As I have never ovulated that late in my cycle I didn't have much hope and the day after the trigger there was no ovulation line at all. So decided to skip the pred + meds as we had been told we need a break soon anyways. Will try again on 10mg letz this month but AF is now late (not because I'm preg!). Both cycles they said Dr S was too busy to see me so I saw Dr Edge, has anyone else been treated by her? She seemed a bit unsure during the appointments so that hasn't given me a lot of confidence.

Sending love to all and glad to be back xx

taffeta00 · 16/03/2022 08:03

I’ve seen her - she actually gave me more time/ patience than Mr S ie not booted out after 15 mins!! Aww re puppy. We could all congregate in Epsom and do sone mystical baby dust inducing dance to the powers that be..?!?! I’m willing to try anything tbh lol x

myrainbowjourney · 16/03/2022 08:15

@taffeta00 I have questioned some of the timings before, and in the end it stressed me out even more, because they just say that Dr S knows what he's doing and to go with exactly what he said. Which is probably the right attitude to have, otherwise what are we paying him for?
I do get confused though because last cycle I took my trigger a week later than usual, to try and catch 3 smaller follicles. But I had a strong OPK beforehand and just wanted to know what would actually happen if I ovulated on my own - would I ovulate again? I still don't think I've had a clear answer about it and I don't know why it's a difficult question to say yes or no to. It really stressed me out. I know tracking is likely pointless but it was also just the timing of the trigger, I knew there was a risk I'd ovulate by then. That's why I think it's easier to just trust it and not get caught up in OPKs and temps, because I don't think they tell you as much as the scans and the treatment plan isn't amended for it.
Totally with you on the social stuff. I'm tempted to allow myself a glass of bubbles when I'm at dinner next week, because I want to enjoy life around all this, but then I get this niggling guilt. It's so much pressure already, let alone feeling bad for socialising!

@Trytryandtryagain11 so grateful for this space. It's so hard for a majority of people to understand, because luckily not so many people have to go through this. It's the comments like take some time off from it, just get away, just keep enjoying yourself, as if it's that easy or that is the answer.
I'm a bit of a super ov veteran, I've just done my 6th cycle. But I'm disadvantaged because I only have one tube after an ectopic. So in my head I want a fair few tries when the follicles are on the right side, which more often than not there aren't, because that's just my luck! Last 2 cycles I've had multiple follicles but on the wrong side. I know the tube can move but it's obviously much less likely.

@89Hope glad you found us 🥰. Love pups, what did you get? We got a puppy in 2020, about 6 months after the first loss. He was such a welcome distraction and still makes me smile when I need it most. Comes and clears my tears away too when I'm sad. They are the best ❤️
Sorry you've not had a good start to super ov. What were you doing before? Assume it was something if you were due a break in meds.
It's so frustrating when the follicles don't show. I know they can't control that but it doesn't make sense, and it feels like such a waste of money when you go in and there's little or no response. It worries me, because I went into it thinking that this was almost guaranteed you'd at least get follicles. Because my first few I did, when I went in and there was one, I was devastated. And now I dread going in to the scans.

I've seen Dr Edge twice, and once with Dr S. I think she's really lovely. In both the appointments on her own she had to call Dr S, but I was pleased she did that to get his opinion. I agree about being a bit unsure, I guess she's just learning the ropes, but it does make me nervous because you want to make sure you're getting the same level of care. But then I always remind myself that he wouldn't have anyone on his team that weren't top of their game

I'm waiting for my tracking appointment from the clinic. They are normally really good coming back to me but I asked for this yesterday am and haven't heard back xxx

myrainbowjourney · 16/03/2022 08:15

I'll be there for the dance @taffeta00

Sezmarelda1 · 16/03/2022 09:52

@VenusStarr I'd be really interested to hear what Dr S has to say about the possibility of over-suppression of the immune system. Prof Quenby has recommended just Pred for me, but I'm also on long-term immune suppressants for something else, and part of me wonders if my problem is not an over active immune system but an underactive one because of the long-term immune suppressants I'm on. I looked at the timings for my five pregnancies (1 successful, 4 MC) versus my dose of immune suppressant (it's given once every 8 weeks), and the one successful pregnancy I had was the furthest in time from my dose of immune suppressant. It does worry that I'm barking up the wrong tree with Pred. But then other signs do point to me still having an over active immune system (I have a chronically raised ESR, and other signs like patches of psoriasis that appeared a couple of years ago). So yes it would definitely be interesting to hear what Dr S thinks about over suppression as I've heard that it can lead to infertility and miscarriage in a similar way to having an over active immune system can. I've been searching for somewhere local to have reproductive immunology testing done (I'm not great with travel) but haven't had any luck.

@Trytryandtryagain11 I'm sorry your first month of superovulation didn't go as hoped. I can understand you feeling deflated. Fingers crossed the increased dose of letrozole makes a difference, and for you too @89Hope.

89Hope · 16/03/2022 10:54

@taffeta00 Definitely up for a dance! 😂 In all seriousness it would be nice to talk to people who understand, I never talk about it to anyone except dh and its hard going.

@myrainbowjourney we have two terrier-poodle crosses. The first last year and decided it was time for a second. It makes a big difference to have something else to focus on other than cycle, meds and forcing intimacy! I was on complex plan of pred/cyclogest etc for 3 months first. Its hard as the first 2x times we got pregnant it was immediate without even tracking ovulation and now its been 7 months of doing all the right things at the right timings and nothing.
The process can be so frustrating isn't it???!!!!!

myrainbowjourney · 17/03/2022 12:06

@89Hope I know how you feel. I don't feel like we could have done anything more than we have in the last 6 months, unless we were on the ivf route. And it's still not happening. So disheartening.

We've just booked a break away for May, just a few days. This will be over my break cycle so it'll be so nice to switch off.

myrainbowjourney · 17/03/2022 12:07

Oh and @89Hope, my next appointment is with Dr Edge again too

Arwen7 · 17/03/2022 15:25

Hello everyone,

I hope you don’t mind joining in. I did introduce myself a while ago but we took a break ttc and so now we are back in the game.

I have had 1 ectopic and 3 mc (11.5w, 6.5w and 8w if I remember correctly) - all mc in 2021. We went to see Mr S in December and I started on the complex plan in Feb and got a BFP so I went last week for my 1st dose of intralipids. After all the heartbreak and money spent I am so anxious but trying to take one day at a time and keeping busy at work (I’m a midwife!). I have my 6w scan with Ms Edge the 1st of April, just hoping everything goes well until then.

I hardly have any symptoms other than cramping (freaks me out) and mood swings.

Keeping you all in my hearts and hoping 2022 is a good year for all xx

myrainbowjourney · 17/03/2022 17:11

Hey @Arwen7. This is lovely to hear, congratulations. It's so nice to hear success stories as you start to wonder if it'll ever happen!

Fingers crossed for your scan, not too long to wait now. So was it success first month trying then? That's amazing 🥰

myrainbowjourney · 17/03/2022 17:13

@Arwen7 also, I'd always look at the symptoms thing as if you have none, you have no worries with any fluctuations. I remember having super sore boobs in one pregnancy and then one day they just weren't. It made me panic so much. I'm sure sometimes it means nothing, but I do sort of hope I don't get any so I can't worry myself.
Plus lots of people don't get symptoms until later on so please don't panic ❤️

Can I ask if you lost a tube with your ectopic? I'm so sorry for all your losses too xxx

taffeta00 · 17/03/2022 19:38

Good luck Arwen7. It’s lovely to hear a success story - lacking on here recently.
I’ve just started cycle 5. Trying to stay positive but really struggling. I was so hopeful when I first saw Mr S and that feels like it’s disappearing :(.
Good luck to everyone for this month x

Arwen7 · 17/03/2022 20:26

Thank you @myrainbowjourney and @taffeta00
I can only imagine the fustration of waiting for it and not happening - but it will!
I’m very cautious to call this a success as even though we are very lucky that it has always worked on the first try, I’ve never been able to keep one past the first trimester! So fingers crossed Dr S plan makes a difference this time (last time I tried aspirin and progesterone but did not work, S disgnosed me with ‘high’ nk in pregnancy).

I know symptoms don’t mean anything. Just wish the cramping would go away as it feels something is wrong but I do know it’s very normal and down to implantation/stretching. I should not complain could be much worse and they do say steroids can mask symptoms too.

@myrainbowjourney I did not lose a tube, it was treated with methotrexate. Funnily enough, all 3 (now 4) pregnancies after that have been from the other tube though (I know because I can feel ovulation and it was confirmed in scan!). So I wonder if the other tube it’s just not healthy enough and not being used by my body.

Good luck ladies, I’m following you and will keep you posted hopefully with some more good news xx

myrainbowjourney · 17/03/2022 20:27

I feel the same @taffeta00. I thought I'd found the answer and it would just work. I thought my problem was staying pregnant, not getting pregnant. Now I can't get that bit, and it's only the first hurdle!

Yes, fingers crossed, all the luck and all the baby dust for everyone waiting for their rainbow xxx

taffeta00 · 17/03/2022 22:27

@myrainbowjourney I’m sending you a huge hug. I bought myself some flowers, did a long walk, prayed to the universe and new moon and now I’m trying to not think about it. Hope you all have a restful weekend x

Sezmarelda1 · 18/03/2022 09:34

I have my fingers crossed for you @Arwen7! Last year must have been so difficult for you, really hoping 2022 is better! I also wouldn't worry too much about a lack of symptoms at this stage - it's very early on still and they may hit you later.

@myrainbowjourney are you going anywhere nice for your break in May? I've been thinking of booking something too, although I hate travelling so I've been putting it off. It's nice to have something to look forward to though, especially when this can be so all consuming.

myrainbowjourney · 18/03/2022 09:48

@Sezmarelda1 just a few days in Cornwall. I wanted to go abroad but it just wasn't going to work out with the days we had, and now we have booked it I'm actually really excited. Will be nice to be able to take the dog, be right on the beach and just have a change of scenery and routine. I feel like I wanted to go abroad, not only for the sun, but to get away from all this. I really need to be able to manage the situation without literally running away from it. Will still be here when I get back!

Hope everyone is ok today? xxx

taffeta00 · 18/03/2022 10:22

I am systematically deleting all commercial Mothers Day emails - so many!! Ggrr

Sezmarelda1 · 18/03/2022 10:36

Cornwall will be lovely, I'm sure @myrainbowjourney. I love being by the sea, it always makes me feel so refreshed.

Mothers day is a hard time for those who have miscarried or haven't been able to have a much wanted child. Sending big hugs @taffeta00 x

89Hope · 19/03/2022 09:40

Got fingers and toes crossed for you @Arwen7
It feels like a lot of us got pregnant quickly pre plan and now are struggling when on the medication. You hope it means it will stick better once it comes but it's hard to silence the doubts.

Has anyone skipped a period on the superovulation plan? My cycle has been 24-25d for 5x months and now I'm on day 33 with nothing. Def not pregnant, 5 wasted tests in the bin over this week! But I should be ovulating this week so don't know if that won't happen as no AF.. V strange. Will email clinic on Mon if still nothing.
Happy weekend to everyone, hope you all have a nice time enjoying the weather.

Arwen7 · 19/03/2022 14:13

Thanks so much for your good wishes everyone, it helps being able to talk to other people who get it and especially because I haven’t told anyone as it’s so early.

I do feel like getting pregnant so quickly has something to do with the miscarriages, maybe my uterus just implnting any egg even if it’s not good! Nobody has mentioned it though and hoping that this is a good one this time.

@89Hope that is so fustrating but you are already doing all you can to fall pregnant so best thing is to try and relax as much as possible - easier said than done I know - and it will happen. Sending all of you struggling to conceive lots of good luck and for one to stick soon 🤞🏼

@myrainbowjourney Cornwall should be great and a break is just what we all need don’t we - I was on holidays this last time when ttc and it definitely helped so much, meant I was much more relaxed.

Have a good weekend everyone! I am working today and tomorrow all day and there are so many babies I’m just running around all the time… at least stops me from worrying about my own pregnancy.

Xx

WillowTree0721 · 20/03/2022 15:19

Hi all I've just caught up on the last week of messages. I'm sorry I've been a bit quiet. I've really struggled this week with anxiety and just had to take a break from my phone. I've had this group in my thoughts though and I hope you are all ok.

I ended up getting a positive pregnancy test this week but my weeks haven't moved from 1-2 weeks to 2-3 weeks on the clearblue urine tests. Had a meltdown as I'm so worried it's another chemical.

Ive been to my local hospital and I've had my HCG levels checked. My HCG level came back as 337. Can anyone tell me if that's a good or bad result for 4 weeks pregnant? No one would give me a straight answer at the hospital. They obviously said it's more about whether it doubles so I have to go back to have the levels checked to see if they are doubling but I just want to know whether that's an ok result for 4 weeks...?

There are so many different things on the internet about blood HCG levels and I'm not sure what the ranges are for the UK and whether it's different in other countries? Google has left me even more confused as it's all different ranges depending what you look at. Can anyone help?

To top it off they did a urine test on me in hospital (before my bloods) and said it was negative!! Then my bloods came back at HCG level of 337 and they said the urine test must of been faulty. They obviously didn't use my first morning urine and I had just drunk a bottle of water so my urine would of been diluted but the dr said that doesn't matter and it must be a faulty test. He said bloods are more accurate. Is this true? I'm freaking out how their urine test could of possibly been negative 😭
I'd be so grateful if anyone can offer any advice xx

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