Immune/NK cells - pred thread 28

[myrainbowjourney]

Hi Ladies

New thread 🥰

If you comment to hold your place. I'll try and tag as many as I can xxx

@Tumby: I'm sorry to hear that you are struggling. I'm thinking of you and hope you will find your own way of coping and maybe come to peace with what has happened.
I second @treesall take the time you need.
I know how hard it is, whilst still on that journey, being reminded every day.
Remember what a strong woman you are.
Words won't make things better, but maybe the feeling that you are not alone. ❤️ One of my Doctors said 'perseverance'. Keep going, stay strong, keep your head up.
What helped me with my first loss was a little ritual. I gathered all of the things that I related to that pregnancy and put them in a colorful little box. You can even write a letter, then burn it or add it to the box. Once you are ready, try to close the box. You won't t lose it, it will always be there, but it's in the past.
Someone also recommended the following book to me. 'The brink of being.' I haven't read it myself, but thought maybe worth sharing.
@badlydrawngirly I hope your husband will recover quickly.
@treesall I'm so happy for you. I hope things will continue to go well. 💕 Don't let others pressure you.

Much love to everyone Xx

Does anyone else fall out with their partner a lot more since recurrent miscarriages? We argue so much now, and all the infertility instagrammed I follow seem to have such supportive husbands. Where as mine can be an absolutely insert your own word here...!

Thanks so much for all your very kind & thoughtful words ❤️❤️❤️ I just feel as though it will never happen & after so many losses (this is the 7th), I just feel like life repeats itself over and over again. Not even sure what I'm grieving for anymore - there are so many triggers. Everywhere I go, I just seem to have a memory of when I was pregnant, or just after I lost one of them. I'm 38 now & everyone seems to be telling me about how my chances will decline with age, and Dr S said it was probably a factor in the chromosome abnormality. Just feel pretty dull to the world tbh.

@treesall and @Lozfish I really am hoping and praying for you guys - sending lots of peace and positive vibes. @Lozfish, do you mind me asking which anti anxiety tablets you're on please? I may need to consider going down that route & would be interested to know your experiences xxx

Hi girls! 👋 Havent been on here for months, how is everyone doing? @Lozfish congratulations on your pregnancy, that's lovely news and @treesall can't believe you are 18w now?! Where has the time gone? Well not much news my end, I went on holiday to Cyprus after our last (7th) miscarriage and it was amazing, just what I needed to escape everything for a while. I'm now getting myself psyched up for my last frozen embryo transfer in a month or so. @Daffodil21 I took your advice and went to the clinic you recommended! 👌 I've got pred, hydroxy, clexane, metformin and high dose folic acid all sorted plus the doctor recommended doing the intralipids aswell at my ivf clinic. She was super nice and it's taken the stress away from having travel up and down to Epsom for appointments and intralipids... it was just getting too stressful and hard to organise with my wee boy and my husband taking time off work. Anyway what I was wondering is anybody else on metformin? The doc had mentioned there can be side effects but never really said much else so was just looking for a heads up what to expect as I've never been on that before? Should I go on it gradually? Thanks so much xx ps @Tumby if it makes you feel better I'm 42, now that's old!! 😂 Sending hugs, this whole process is the pits and honestly don't think I can take another miscarriage but have to give it a try or I'll always think what if!

@Tumby I'm on citalopram - 20mg but I started on 10 and they didn't touch the sides. Am really happy on them, I struggled a lot with low moods and failure to find any positivity but I did notice a difference when I started them - I just feel like my old self again. I'm so sorry for your losses and the fact you were so unlucky this time, I'm desperately hoping that next time is your time.

@Luckyducky2 wishing you the best of luck with your transfer, sounds like you're throwing the kitchen sink at it. I always think it feels better when you have a plan of action doesn't it, those weeks after the loss feel like you've been shifted into reverse and are just stuck, unable to move forwards.

Xx

Hi ladies.
Sorry I've been so quiet. I've been trying to keep myself distracted.
So happy to read all the positive, hopeful stories. And sorry to hear of anyone struggling with anything. This journey is a real slog sometimes!

So I did my first super ovulation this cycle. I only had one follicle when I had the trigger shot and my test day was yesterday. I tested and got the squintiest squinter of a line. Hoped I'd test today and it would hit me in the face, but it didn't. It was darker in that you didn't have to hunt to see it but it was still questionable.

I now have to be patient until tomorrow but has anyone had this? Is Dr S's recommended test date a squinty early date? Clutching at straws but just wondered if anyone had any words of wisdom xx

@myrainbowjourney the recommended test day is definitely a squinter day, definitely not questionable... two lines is a positive, no matter how faint. Also good today got a little darker. If you're 10 or 11 DPO you shouldn't expect to see anything dark for a couple more days. Congratulations on your BFP! x

Thank you @Lozfish. Were yours like that? (Congrats to you too 🥰)

I am already filled with so much anxiety and doubt. I'm not sure I have high expectations for the morning. Such a negative way to look at it 😭

How are you getting on? x

@SunDance21 @Annabell1 thanks for your messages about my dodgy side effect - it seems to have been a one off thankfully with no other issues so I'm relieved!

@Badlydrawngirly sorry you have been feeling so down about things - that's so awful about your husband though, I'm not surprised you are feeling depressed. I'm also struggling to find the positives in life at the moment. We've been dealt a shit hand and the only thing that keeps me going is believing that this too shall pass.

@SunDance21 well done for taking your injection! I did my second one on Friday and it was a lot better than the first one - no tears this time! 💪 not good about your bruise though 😬 I do argue with my OH more these days too, I think it is all the pressure we are under. We are also doing a house extension project and have a puppy so we have a lot on.

@VenusStarr good luck with your FET!

@Lozfish so glad your scan went well 😊

@treesall aww I am sure it will start to feel more real for you soon, although I can totally understand how you feel. Soon there will be no denying it! Doppler sounds like a great idea if it works for you. 👍 your family sound like they are being really difficult 😬

@Tumby so sorry you are also struggling. Your feelings are normal and you have been through so much. Logic says eventually the pain will be less but it's hard to believe it when you are living through it.

@Luckyducky2 that's so great you are getting treatment locally!

@myrainbowjourney a line is good news - his testing date is early at 10dpo. Lots of BFPs don't show up until 13dpo (my last one was 13dpo). Quiet congratulations!

Thanks everyone for your kind wishes!

I just can’t believe the timing of everything. It’s 4 weeks since my withdrawal bleed and I still haven’t started my cycle so I’m going to the clinic for a scan on Thursday to see what’s going on and to see when I can start meds again. I kind of just want to get started and get one cycle out of the way even through mentally and physically I’m probably not ready!

Wishing everyone else the best of luck! X

@myrainbowjourney mine were like that yep. I decided to only do two tests, one at 10DPO (very faint) and the next at 12DPO (darker but not fully dark) and then I considered myself pregnant until proven otherwise. Am now 8 weeks, have been feeling terrible since I tested positive which has helped a lot with the anxiety, but it was up and down for the first couple of weeks and I was worried intermittently. The scans are terrifying but Dr. S is amazing. Yoga has helped me keep on top of my anxiety and I'm just trying to distract myself with work and plans (when I'm not sleeping!) I really hope your test gets a bit darker tomorrow and you can have a little bit more confidence 😘

@Badlydrawngirly sorry to hear everything that's been going on, it's totally understandable you feeling how you are. I hope your husband has a quick recovery. Be kind to yourself ❤️❤️

@Amy00 thank you. This gives me hope but equally I'm not holding out much! I think the lines would have got darker by now. I'm potentially 11/12dpo today so I thought it would be more obvious. Such a negative nelly! Will keep everything crossed to be proven wrong!

@Lozfish it's the dream to just test a couple of times. I was a right idiot tonight and decided to use a clear blue with no hold of wee or liquids. The dye ran and there was no way of seeing a line, but there wasn't one. So now I'm feeling worse! Someone needs to lock my tests away!
I guess the symptoms are a good thing if for nothing other than keeping your anxiety at bay. Distractions are always good! So exciting you're 8 weeks now!

Let's see what happens tomorrow morning 🤞🏼🤞🏼🌈🌈 xx

The line is no darker this morning 😭. Something didn't feel quite right it's just annoying to have the glimmer of hope. Fingers crossed for next cycle! 🤞🏼🤞🏼 x

@Luckyducky2 that's brilliant! Glad you got the meds. I think metformin CS cause a bit of stomach upset. I've taken it before but only for s couple of weeks. I didn't get any side effects. Wishing you all the best for your IVF x

@myrainbowjourney so sorry to hear that. I think maybe leave it a couple of days and test again just to make sure - your HCG doubles every two days so at this very early stage there is a possibility it just needs a little time to get there. Have you spoken to the doctor to check whether you should have intralipids? x

@myrainbowjourney I'm sorry the line isn't any darker 😔 it could still be affected by how hydrated/dehydrated you are and it is still very early days so there is definitely still hope! I had a chemical in November last year and had very faint lines for 2-3 days and then on the 4th day there was no line at all (happened to be my birthday 👎👎) and on the 5th day I started AF. I just knew something wasn't right with it and it was easier to come to terms with it as I knew deep down it wasn't right. Such a horrible time though, is it or isn't it, sending you hugs xx

@Lozfish I asked the nurses and they have told me to stop taking everything and just go again next cycle. So I guess I'll next be in for my follicle tracking and intralipids.

I just feel a bit hopeless today. Before the faint lines I was feeling positive about the process, and knew for it to work first time would be super lucky. But like you say @Amy00 I'd rather to know, I didn't expect the questionable tests and testing my emotions. It's the unknown couple of days that's just makes it worse! It's like I had a glimmer of what could be and it's been taken.

I actually wonder if the trigger shot was lingering. I had a chemical for one of my previous losses, and had darker lines than I had this time, and my blood hcg came back under 5. So I wonder if the slightest trace of the trigger could have been there.

@Amy00 sorry to hear about your chemical - on your birthday too! It really is a horrid time, I miss the nativity of just thinking I'd get pregnant and that would be that

What is next for both of you? xx

@myrainbowjourney I've just had my two injections of anifrolumab which is to bring down my TNF alpha (I had high levels and Dr S said this can cause chemicals - did yours come back normal?) and then I'm hoping this cycle we can actually start trying again after the miscarriage we had in July. Need to get my prednisolone, Cyclogest and omeprazole.

We have a zoom appointment with Dr S tomorrow, does anyone know how long it takes usually for them to post out the drugs? I'm due to ovulate Sunday/Monday so need the drugs ASAP if we want to try this cycle and I am SO ready to be trying again, it's felt like an age.

Although, also dreading the horrible cycles of hope and disappointment. It took us 7 cycles to conceive last time which I know is not long at all compared to how long some people have to wait so we are lucky really, but when you keep miscarrying it just feels like such wasted time?! Like we need as many chances as possible!

@myrainbowjourney I know exactly what you mean about naivety... one of my friends asked me with a previous pregnancy why I was taking tests every two days - I was so jealous that with her two she just did the one test and then everything was fine and had no idea that some people's lines fade. Wishing you lots of luck with your next cycle x

@Amy00 yeah he didn't say anything about that for me. I had high NK cells and extremely high activity of the cells. So I'm on pred, progesterone and intralipids. I also ovulate late and have long cycles. After an ectopic, so a tube down, Dr S has only suggested trying for 6 months, so we are also doing super ovulation. Basically throwing everything at it.

Totally agree that each month it doesn't work feels like a waste, I know that feeling too well. It's just such a shame it all feels like life revolves round cycles.

I'm glad you are on the verge of getting going. After my first appointment I just wanted to crack on, but was away for work when I would have had my scans so we had to miss the first. It's horrible having to wait.
I've had my appointments in the clinic so I'm not sure about sending meds. I'm sure they will send them out quickly.

@Lozfish ah the dream of taking one test and that's it. I'd love to be able to do that but there's just no way.
Did it take you long under Dr S to get pregnant?

Hi eveyone

just wondering if anyone could give me an idea of whats going on. Im 5 weeks preg and having a SLE flare . My arms arms are aching and my joints and my symptoms seem to have disappeared but i dont have any bleeding or cramping. Im on hydroxychloriqine and vitamin d atm wondeering if i might need more meds. I cant access my rheumatology dept at the hosp atm. Any advice is appreciated.

ive had two losses already one at 20 weeks and another at 7 so really worried this one is heading the same way

@MadamMaltesers I'm afraid I don't have any knowledge around SLE, however when I was 5 weeks I felt my symptoms disappeared for a bit but they came back a few days later and got a lot worse. I remember thinking I must remember this for future pregnancies and also to reassure people who are going through the same thing.

@myrainbowjourney it took us two cycles, but I do know the frustration of waiting - I saw Dr. S at beginning of June but couldn't try until august as I still had retained tissue from my previous miscarriage and I needed to have three operations to sort it out as well as waiting time to see whether I had scarring (I did), so he wouldn't let me try until I got the all clear - nothing more frustrating than waiting out cycles. How long have you been trying on his treatment plan? x

@Lozfish thank you, i hope its the same case for me too. Il wait till 6 weeks and go for a scan x

@Lozfish I'm going to remember what you have said about symptoms. This time I felt really sick leading up to testing, boobs hurt a bit. Then it stopped. And I made a mental note to stop torturing myself about having symptoms. Otherwise the anxiety if they fade if I ever get pregnant will be immense.

Also have to remind myself I had these and wasn't pregnant so not to hang my hat on them next time. Keep forgetting the trigger shot has hcg so it probably caused a lot of it.

So because I was in the states on the follicle tracking days on my first cycle after getting the plan, I just did a cycle 'blind' and tried to guess when I ovulated. Typically I think it was too late as I got back from America and then think I ovulated pretty much straight away so I don't think we had the best chance. Then this last cycle is my first super ovulation, so the first proper guided cycle with Dr S.

On my scan, I had one dominant follicle so he has upped my letrozole for next cycle as he wants 2/3 each ovary - gives me a better chance with having one tube. So at least next time there might be even more chance 🤞🏼. It was also day 14 and he triggered me that day. He said next time he wants to see me sooner. So I do feel like I've had my trial and error cycle and hopefully the next one will be a better go. That's what I'm telling myself.

I know I'm early days, but I was so hopeful with a new plan in place. Just want it to work!

2 cycles isn't bad at all, although I'm sure it felt like a lifetime. Did you do super ovulation?
Sorry to hear about your retained tissue. What a nightmare. Did you have the treatment for that under the nhs?