Immune /natural killer cell treatment when ttc or pregnant (aka the 16th pred thread!)

[sunnyday01]

This is a thread for those diagnosed with high or very high natural killer cells and trying to concieve or are pregnant and taking steroids/intralipids etc

Newcomers very welcome

And congrats on the puppy!!! Cuddles galore now :)

Well that will be the next question once we know. DrS says to keep trying for now. But to be honest...if it came back that there's a translocation I want to go straight down the Ivf route. I thought a chromosome issue would ease my mind but it's opened a completely different can of worms. At least i know the treatment works.

Seeking - sorry you ve got this added worry and how crap the nhs hadn t reported the results initially, altho at least if you ve already had them done you ll hopefully get an answer soon. I hope its just a rare one-off. Yay for the puppy, sounds just what you need right now.

Yeah Dr i am too curious to not have the scan and hopefully there will still be something to see.

It's definitely a bit of a head f*ck Hula!
But puppy has definitely helped lift my mood.
Hope you're scan shows what you need it to tomorrow, fingers crossed for this cycle!

Thanks Seeking.

I m glad the puppy has helped.

Good luck with your scan hula.

I can't asvise on ovulation before scan as I never did opk' I just left it to the scan!

morning girls.

sunny great news re scan
rosa - great to hear from u and that all is still going well. i hope ur right and its just a numbers game....its hard to keep the faith sometimes!

hula - loads of luck for scan today i hope there are 2 juicy follicles there if not 3!

snoopy - sorry about ur SIL, its really hard. just try limit contact with her if you find it too hard and like swannny said, its not ur baby she's having. urs will come one day. sorry ur period seems messed up. my cycles were never effected with the pred, they always came on time as usual.

seeking -was thinking about ur appt. u must be quite confused. wasn't that you were expecting to hear, this whole jorney sometimes gets more and more complicated doesn't it. i really hope its a one off thing and u don't need ivf with PGD. have u started chasing for it yet? are u still going to ttc or wait till u know results? YAYYYY TO PUPPY!

determined - no af yet?!!! what!! I'm sorry :( what a pain. SO will sort things out for you, but its so frustrating

swlondonnanny - I'm sorry u have trying for so long, it must be so frustrating. but your armed with so much information and i hope next time the tx works. if u do ivf, I'm more than happy to pass on my limited knowledge! but i hope it happens before

i had a lovely holiday was SO hot. my friend doesn't know I'm even TTC and she's single so was nice to not discuss my issues and have girly time and just switch off. i drank too much and had a lot of ice-cream!! i really needed it. don't have too much to add as TTC isn't really actively happening as chances r slim its nice to DTD when we feel like it now!! i have a follow up with my IVF clinic next wed, and we seeing urologist in 3 weeks hoping the tamofien will have helped rise DH sperm count so we can freeze some more. i have to admit i did spend some time yet looking into surrogacy, trying to stay positive it will happen but as we all are, worried it won't ever happen....oh also i have a COLD bleugh!

have good weeks and sorry if i forgot anyone xxx

sorry DRTTC forgot to say hi! i hope the intralipids were ok and that u do get lucky this cycle!!

Hey Trying! Sounds like the time off is exactly what you needed! Love little breaks where you can just forget... You go back to that younger version of yourself that had all this hope & confidence in the future. Lovely feeling! I'm sure the urologist appointment will go well and you'll keep banking. Are you holding off on ARGC?

Regardless of what happens, I'm waiting on money to come through on a flat sale before I invest in some more testing. Want to test for translocations on both sides, SA, and sperm fragmentation... Atm my ttc plan is to do intralipids before/at ovulation for 3 months & see what happens. I may skip Pred next month if it messes with my cycle though!

Otherwise I'm feeling pretty good! Feel like I've fully bounced back finally. However, we have a wedding this weekend... And we're sharing a cottage with THAT pregnant woman I've told you about. Will be doing my best to stick by my husbands & avoid her & her stupid comments. Oh did I mention 10dpo will be the morning of the wedding? Last time I got BFP at 10dpo.... So yeah. I may be crying sad tears for myself during the wedding ceremony haha!

hi drttc! sounds like a good plan. there is GOOD evidence of the role of fragmentation in miscarriage i don't know why its not so widely down or spoken about. my DH is going to have his done in a few weeks at urology appt as u have to have a certain number of sperm to do it and he didn't have enough but hoping it might have gone up (was only slightly under). however the urology doc didn't think it would be a problem as we made a good number of blastocysts in IVF and usually if its a problem the embryos die off on day 3....but anyways would rather get it checked out!

no def going to ARGC, was going back and forth with what to do. but me and DH think, seeing as we want to do another fresh cycle of ivf anyways we should go. although i found IVF OK, it wasn't v nice and i don't fancy going through millions of ivf cycles and miscarrying each time. it was quite unpleasant but bearable and worth it if it works (and i think it was that hope which made me OK during it) - lack of sleep, bloating side effects of meds, weight gain etc........i think I've got to a stage where i need to throw everything at it and i want that constant monitoring and reassurance after a bfp...the IVF side of it is what was swayed me to go there.....if it doesn't work then i have NO idea what we will do, prob just keep trying frozen cycles until money runs out!!

sorry ur having to stay with her...grrrrr...stay strong and avoid her....fingers crossed for a bfp, u do get them quickly!

Sorry hula I don't know on the trigger shot question. I would presume if you had already ovulated there'd be no need for it? Would the scan be able to show how many eggs are released afterwards? I know they can sometimes see the corpus luteum.

seeking I'm glad you finally got the results. On the one hand you know you did everything you could for your little one and I would try to take it as a positive that the meds seemed to stop you miscarrying but I understand your worry about the karotyping. That has always been a worry of mine too, but there are ways to deal with it if that were the case.
Also I demand puppy pictures!

drttc it's so frustrating. I've stopped taking the steroids until the ovulation tests start to fade. But now I'm worried there could be some other factor like PCOS. It's exactly what I didn't want, to be constantly weeing on sticks and tracking everything, but I guess needs must. The second ovulation test completely bamboozled the ovia app which changed my most fertile day to yesterday but still thinks my period is starting today.

When can I expect to ovulate if I've had two positive tests?

Didn't notice trying was back! Sounds like a great holiday!

Glad you had a good break trying, hopefully it gave you a few days 'off' thinking about everything.

I've just finished my last I tralipid and taken my last steroid today!

Trying, you seem to have a good plan in place. I really hope you find what you're looking for or get that bit of 'luck' soon. It's got to happen!

Snoopy- I wish we could just forget as well! On babycentre you always see people saying 'don't test until after AF is due!' 'Just forget & relax and then it will happen!'.... But being on treatment makes that impossible!! Not sure what you can do except hope that blip is over with and that your next cycle is back to normal. It does seem to eventually get back to normal for everyone.

Yay Sunny!!! That's so exciting! Well on our way to seeing 3 Pred babies come out of this 2015 lot :)

Glad you had a lovely holiday Trying, sounds like just what I need!! DrS told us to wait until next cycle before we try again. I've chased the results and my consultants pa is sending them out today so, hopefully should have results by the end of the week. Absolutely shitting myself to be honest. The reality of what could be is so scary. Very worst case scenario is 0% chance of normal pregnancy. Which would then involve donor/egg or sperm. DH is completely against donor sperm, where as I'd use donor eggs if need be. Perhaps because if still carry it, I'd have a connection to it.

Snoopy- it's so hard when your body doesn't play ball. I had several months like that and a couple where I didn't ovulate at al ( I was temping).

Drttc, I hope you're pregnant 'friend' isn't in bitch mode again. And I hope you have something to smile about on the day of the wedding.Sound alike you've got a good plan in place though.

Hula- how did it go?

hi seeking, i know its so shitty when the path gets more complex....however, i suspect if you didn't hear from the consultant about the results they are prob ok as if there was an issue u would have hoped that they would have called u back in.......also, i don't know too much but if u or DH are carrying a translocation i think it would mean 50% of embryos would be affected...not 100%....so don't panic yet.....i hope the post comes soon. its just one worry after another!

Bloody hell scan was waste of time and money as looks like i d already ovulated. Had a small 11mm follicle on each side, one of which looked to be collapsing but he couldn t tell if i d ovulated one or two eggs. Only good thing was lining was good at 9.2mn. Wasn t with dr s so waiting to hear what he says but can t see any point of taking the trigger and can t see him being able to change the dose since we don t know what this one did. Arrggg so annoying !

Trying - so glad you had a good break.

oh hula I'm sorry, u tend to be a quick ovulator when u get ur positive lh stick don't u?....hopefully 2 eggs came out and at least u DTD the other day....im sorry, will maybe take a few cycles to get things perfectly timed???.great ion the lining i only ever get to 7mm (more often 6) which i think is a problem I'm hoping argc addresses.....

Oh that's crap Hula Hopefully though you've done enough to have caught the egg(s) any way. Rubbish that you won't know wether this dosage is corrector not though.

I know that if either of us are carriers of a translocation it doesn't necessarily mean that we're 100% out, but the issue the baby had was so rare -unbalanced robertsonian translocation with the same chromosome. Normally it's between 2 different ones. There are rare cases when carriers have both chromosomes fused which essentially means they will never produce 'normal' babies.
If either of us has a balanced translocation it means theoretically there's a 1/6 chance of normal pregnancy, 1/6 chance of same balanced translocation and 4/6 chance of chromosomal defect. It's scary!! Google is a scary place at times!

Thanks Trying - yep i think i must ov pretty soon after and at least we did dtd yesterday so prob was pretty well timed, dh will get an easy month this month ! I knew it would be tight to try and stretch scan to day 12 but with the weekend and work i had no choice. I would think the argc would be able to help your lining with such close monitoring, i think you can have oestrogen patches if your levels are low.

Gosh Seeking sounds scary but i d try and stay away from dreaded google if u can until u have your results as u may be putting yourself thru unnecessary worry. Sending Hugs, the uncertainty must be horrible.

oh i see seeking, i have everything crossed that it was a rare one off thing.....im sorry i know what it feels like to think u have maybe hit a brick wall and don't know where to go from. BUT we all always think worst case....and usually its not WORST case, it just means a change of plan...i don't know if that makes sense!

but when dh sperm was low i went into google frenzy mode and found stories of men needing surgery to extract sperm and there not being any there and it was TOTALLY not needed and worried me for no reason...i automatically jumped to worst case scenario and panicked HUGELY....its hard not to google! but before u have all the facts keep everything crossed. well I'm crossing them for u.....:)

Oh hula that is so frustrating, will be interesting to see what Dr s says. I had to go on day 11 at the latest as I had a few months where they said I had I e ready to pop!

hula how annoying. Hopefully you caught the egg/s though. Would it be possible to have the scan earlier next cycle if needed? Sorry, I'm so ignorant when it come to this super ovulation stuff.

seeking I know it's very hard but please try not to worry until you have all the information. I have a friend who had two girls with his wife and then she had a surprise third pregnancy. Despite a normal pregnancy his son almost died within twenty four hours of birth and tests revealed both he and his wife had balanced translocations. And yet they have two healthy girls and didn't have any idea there was anything wrong. I know this story is a bit doom and gloom but even with their complications they have had children.

Thanks Snoopy I know it's not all bad. And really right now I'm not worrying too much. I know there is a way round it. To be honest I'm just relieved the treatment stopped me miscarrying so I have faith that it will work. I have to just accept the rest I guess.