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Conception

When's the best time to get pregnant? Use our interactive ovulation calculator to work out when you're most fertile and most likely to conceive.

TTC/ pregnancy on Prednisolone or similar

999 replies

freelancegirl · 13/06/2011 16:21

I am not sure there are enough people here to start a thread but have been chatting on one on the pregnancy boards and was wondering if I could find any fellow ttc'ers on Prednisolone or similar?

I have just received a diagnosis of very high NK cells. It was a bit of a shock actually as it turns out I have some of the highest levels - 3.79 when anything over 1.8 is considered 'very high'.

Am trawling through Dr Beer's book and Dr Google and trying to found out more. I have been recommended 25mg prednisoline steroids for two weeks starting with ovulation, increasing to 40mg if/when BFP and then Intralipids Cyclogest too. I still have 13 days until I pop my first Pred.

There now just seem like so many hurdles - actually getting pregnant being the first one. I was prepared for high NK cells as I have high thyroid antibodies but it was shocking to be in the top 5% of people treated at the clinic. I am not sure if that gives me much less of a chance of being successful.

It would be great to hear from anyone else who is undergoing treatment and of course also if you've had successful treatment.

OP posts:
digitalgirl · 08/08/2011 10:31

Good luck georgie

Will be thinking of you on weds free

I don't tend to get many obvious symptoms so I've decided not to focus on that this time otherwise I'll drive myself into an early grave. In fact I'm going to pretend that nothing out of the ordinary is happening to me for as long as possible. I'm only just 4 weeks today. Still waking early from the pred, letting myself eat a bit more so keeping on top of hunger.

eurochick · 08/08/2011 11:02

I'm finding the book really interesting. I'm learning lots!

nediaaa · 08/08/2011 12:32

hi to all.
i am a bloke so please be gentle on me if i havent thing right
We are from Ireland
this is my first time posting and find this thread very imformative.
Our history so far....
Me 35 Better half 36
TTC 7 years.
Tried various treatment
Had Lap and Dye- no problems
Had 4 failed ivf cylces( during which time both my wifes parents passed away)
Last 1 in November
Got a BFP naturally after last failed ivf
it was a blightd ovum
Contacted DR S at the New Life in Epsom
Had tests for NK cells
Turns out they are very very high
Had 3 rounds of Prednisolone and asperin and others drugs
all failed
Going over for uterine tissue biopsy this month
Due to start a round of ivf with them in September.
The journey goes on........

AuPairtoLondon · 08/08/2011 12:52

This reply has been deleted

Message deleted by Mumsnet.

georgiepie · 08/08/2011 13:04

Hi Nediaaa nice to hear from you. Well you found a really good thread for support and information, although I am fairly new to all this medication and Mr S myself!

You say you the pred and asprin failed, does that mean you DP was pregnant when taking those or did not become pregnant? Are they hoping IVF and medication for v high NK cells will work together? What can we do to help?

As for AuPairtoLondon I think you need to do your research before you place random ads for business. Not very sensitive or tactful - NO THANKS!

nediaaa · 08/08/2011 13:14

Hi Georgiepie,
sorry about the confusion. my wife did not become pregnant while using Pred and Asprin. I prob shouldnt have used the word failed. They are hoping the ivf and nk cell treatment will be successful.

digitalgirl · 08/08/2011 13:14

gerogie I've reported that post.

nediaaa welcome to the thread - so sorry to hear of your struggles. I was going to ask the same about your three failed rounds on pred - were you trying naturally? Are you having IVF under Mr S or another clinic? He has amazing success rates, I hope it works out for you.

nediaaa · 08/08/2011 13:32

hi digital. thanks for the welcome.
We were trying naturally with the nk cells meds. We are having ivf under Dr G at the same clinic as Dr S.

digitalgirl · 08/08/2011 13:36

You're in very safe hands then. Good luck! Keep us posted on how it goes.

nediaaa · 08/08/2011 14:47

thanks digitalgirl

iggii · 09/08/2011 10:16

Hello, can I ask a question of the experts?
This is my first cycle of taking prednisilone from ovulation, and I started taking it on Monday when I got a smiley face on my OPK. BUT, I've heard people say steroids can delay ovulation. Am I safe to discontinue SWI after today, or should I persevere keep going? I haven't been waking early enough this month to temperature chart, unfortunately!
So, just wondering if delayed ovulaton is a common problem with steroids (hopefully not).
Thanks Smile

freelancegirl · 09/08/2011 10:28

Hi Iggii! Well done on starting the Pred. It's a big step I think. Feel free to come and bitch about symptoms. I've been on it for 6 weeks now (first 25mg then 40mg when I got a BFP). I was charting with FF for the first time but I think it might have slightly miscalculated my ovulation dates as I had a tri-phasic temp cycle (all new stuff to me!) so I carried on a bit longer than I should have done and bingo, managed to get a BFP first time. I am not saying it is going right, I think it actually might not be going well at all as I don't feel remotely pregnant and the scans so far have been inconclusive, BUT the fact remains I DID manage to fall pregnant. So my advice would be to carry on a few days longer just to make sure :) Like Georgie I think I might have ovulated later than I thought I had, but as it was my first ever month of charting I am not sure when normal would have been for me anyway.

Euro glad you are finding the book interesting. Digi glad you are eating more with me :) I am so damn chubby it's very annoying, especially if I have to start all over again. I don't mind getting fat if I am going to be pregnant but it's a bit annoying if I am going to not be pregnant.

Am now wondering what happens tomorrow if I need to start again - have an op? I think I would rather do that this time than wait for it to happen naturally. Also, do I go off the Pred gradually being that I am on 40mg. I guess I will have to email Mr S and find out.

Looks like I missed an interesting day or so here! Waves to everyone else xx

OP posts:
iggii · 09/08/2011 10:50

Thanks Freelancegirl, hope you won't be getting bad news but I understand the need to be prepared.
Well I DO know about coming off steroids (as I was taking them before mc/4, but not from ovulation) you would be recommended to come off them gradually, reducing the dose over a few days. I believe you can feel ill if you stop suddenly. The doc will prescribe a "coming off" set of steroids. (I didn't do that though, I just broke some of my pills into halfs and quarters and used them as I didn't want to pay for more pills).
I will break the bad news to DH tonight about extra attempts being advised!

digitalgirl · 09/08/2011 20:50

free will be thinking of you tomorrow. Are you going in the morning? You sound amazingly calm about it all. I really really hope it's good news.

iggi hello! pleased to hear you're ttcing again. I've also heard pred can delay ovulation but I don't know how common it is. I wouldn't worry about it too much - but cant hurt to keep on swi-ing as free suggested.

I haven't got round to booking my TEG test. I left them a message yesterday but they haven't called me back yet. Must chase it tomorrow. I haven't even called Dr S. I think I'm in denial.

BrownieGecko · 09/08/2011 22:10

Thinking of you tomorrow Freelance x

Waves to everyone, am on phone so will post tmrw.

eurochick · 09/08/2011 22:32

I hope all goes well freelance!

Havingkittens · 09/08/2011 23:27

Best of luck tomorrow freelance.

Digi I guess you need a bit of time to let the things sink in before acknowledging enough to call Mr S.

Not much to report here. I am on CD13 and no +ve OPK so far. Very feint line today so maybe it will be +ve tomorrow. Been having lots of cramps though, although they are not like my usual one sided ovulation type pains. Felt more like period pains. Strange. I guess we have become that much more hyper aware of our bodies with all this business. It's strange though. With this months impending ovulation I have had a feeling of sadness as if it is the beginning of another 2ww with another disappointing conclusion.

Welcome nediaaa. I hope your next round of IVF brings you more joy. I'm sorry to hear you've had such a tough time.

iggii I'm just about to start my 5th cycle of pred but I've not been temping so couldn't give much idea about whether it delays ovulation or not. I decided to hedge my bets and start taking it after the +ve OPKs (so on the first day that it goes back to just one line).

I've been trying to chart my temparatures this cycle but it's been very inconsistent as I have been waking at all sorts of times. My cat wakes me up at varying random times in the morning wanting food, any time between 5.30 and 8am. I have also found myself waking up to go to the loo at varying early hours too. With all of this I have been just taking my temperature as soon as I wake up and before I get out of bed, as recommended, but not at the same time every day. There have also been at least 4 or 5 days of drinking the night before which I think affects your temperature too so I'm not sure if any of my info means anything! Weirdly, there is a big dip and then dramatic rise in temperatures around days 6 and 7, which is not when I would expect to ovulate. No dip as yet this week. Quite confusing. But then again, the lack of consistency probably doesn't help at all!

batteryhen · 10/08/2011 06:43

Just popping in to say good luck to freelance today xx

Arianrhod · 10/08/2011 11:00

Hi ladies (and gentleman), have you got room for another?

My story: I'm 43, DP is 49, I have a beautiful DD who is 4 yrs 8 mos by my previous partner. Started TTC May 2010 after having had non-hormonal IUD for 9 months. BFP mid-Nov but emergency scan following spotting Dec 22nd at 9+4 showed babe hadn't made it past 6 weeks. MC bleeding all over Christmas & New Year followed by ERPC 13th Jan this year.

OVd 2 weeks after ERPC and shock BFP 2 weeks later, only to have early natural MC at 5+2.

3 months later another (very strong) BFP, 27th May, and this time thought everything was fine, strong pregnancy symptoms, no worries. Had a private reassurance scan the day before we went on holiday at 9+5 to be told the baby had died at 8+6. Total shock, as I thought all was well. ERPC on return from holiday 2 weeks ago now, 26th July.

This second ERPC has hit me much harder physically than the first did, it took me a week before I started feeling human again whereas it took about a day the first time, plus I bled for a lot longer this time too. I'm assuming that's because the pregnancy was further along, plus I hardly bled naturally at all before the ERPC this time. No clue!

I'm now back to using my trusty CBFM and waiting for first AF. The doctor who carried out my ERPC told me the RMC at the hospital (Frimley Park in Surrey, who are supposed to be good at maternity stuff!) most likely wouldn't see me as I have already had a baby. This surprised me - I did my research the two weeks I was on holiday and learned all about the things that can change (like blood clotting issues) even after a successful pregnancy. She told me that my GP could do the two blood tests needed to check for clotting issues, and packed me off. I did raise the fact that I have a different DP - perhaps he may have issues?

Anyway, before I saw my GP I'd decided I want to see Mr S for tests - I'm lucky enough that both DP and I have BUPA with work, and BUPA very surprisingly have been fantastic, they've agreed to whatever tests Mr S wants to do on both of us. So I then saw my GP, told her what the hospital doctor had said, and she was really quite cross - she said she doesn't do the testing on DP and myself, the RMC at the hospital has to! But since we're going to be seeing Mr S she said there was no point referring me to a different NHS RMC since she felt Mr S would take all the same tests anyway, as well as whatever additional ones he may do. She told me if Mr S didn't test DP or myself for something 'standard' that we wanted, to go back to her and she would start the NHS referral ball rolling.

Bearing in mind my age though (I'm actually 44 in Jan), I'm thinking I don't have time to wait the length of time it will no doubt take to get anywhere on the NHS, so I'm hoping Mr S will test for everything! I know it could well be my age that's a problem, although I'm choosing to believe that is not the issue, that there's something else wrong - and hope Mr S will find it! I certainly seem to be fertile enough to get pregnant relatively easily, but for some reason my babies are dying. And I want answers, if answers are there to be found!

Having fallen foul of Mr S's holiday in August, we're not due to see him until 12th Sept (and got follow-up appt for results on the 28th), so I'm reading and reading and reading in the meantime. I am halfway through Dr Beer's bible, and it makes for very interesting reading. I myself have mild psoriasis, eczema and psoriatic arthritis in my fingers, and a family history of chronic asthma, all of which I believe are autoimmune issues. That may not be the problem, but it's a possibility - I've always had mild psoriasis on my elbows and nails but it was only after my daughter was born that I developed the psoriatic arthritis, as well as psoriasis on my knees, which I thought was odd at the time but from reading Dr Beer's book I understand that increased autoimmune issues can result from a successful pregnancy if there are problems. shrug I just don't know, but I'm hoping Mr S can find out.

I'm also taking a whole ramp of vitamins including agnus castus, starflower oil, "super" B6, extra zinc, royal jelly, 5mg folic acid (GP wasn't keen but the hospital doc had recommended it), extra iron supplements which my acupuncturist suggested I should take, as well as a very comprehensive multivit/mineral. I rattle!! And I've started seeing an acupuncturist who specialises in fertility issues, who declared herself horrified I've had 3 miscarriages in 7 months and told me to take it easy. Right - with working full-time and a 4 year old. Nice thought! :)

Anyway, so very sorry for the huuuuuuge length of this post (brevity is sadly not a virtue of mine when emailing!), and it's been so interesting reading and following everyone's stories on here. You all give me hope that my wee lassie may get the little brother or sister that she so desperately wants.

Ari x

digitalgirl · 10/08/2011 11:18

arianrhod welcome to the thread. So sorry for all your losses Sad.
Mr S will test for everything you haven't had done - which sounds like all of it. I'm surprised you weren't referred to your local RMC and haven't been supported by your GP - you really should have been. Although, it's probably for the best that you're seeing Mr S via BUPA as this will save you a lot of time waiting for NHS tests etc. A bit of a heads up for you, Mr S will probably recommend you start taking junior aspirin (75mg), 25micg of Vit D3 and Pregnacare Plus with omega 3. You may as well start taking those now. I wouldn't take multi vits and pregnacare together though - just the pregnacare - as some multi vits have too much vit A which isn't good in pregnancy.
He will also recommend that you don't try to get pregnant until after you get your results.
I am a firm believer in acupuncture therapy and I would listen to your acupuncturist if she says you need to take it easy.
Good luck with your appointment Smile.

Arianrhod · 10/08/2011 12:02

Thanks so much Digi (and a belated huge congratulations on your BFP!). I was also surprised about the local RMC, but in a way not - there are so many issues round here with funding, it all seems to be about money these days. I had fantastic care at that same hospital when my daughter was born, but that was almost 5 years ago, and my experiences since the start of my first MC last December are very different.

I have got low-dose aspirin already but thought I shouldn't start taking them until after the blood tests are done - couldn't it possibly interfere with blood clotting tests? I thought I'd wait until Mr S tells me to take them. I always take Pregnazon when pregnant and I still have some of those left, so I could take those instead of my multivit (they're for pre-conception as well, very similar to Pregnacare), and I always take Omega 3 when pregnant too (I'm vegetarian, and take them for the baby's brain development), so could easily take those too. My existing multivit has 15mcg of vit D3 so although not quite up to Mr S's level will get me by for the mo

I wasn't planning to start TTCing until Mr S's results come through, partly because I want to know what the problem is first and partly because my poor body needs a break. It's actually weird trying to get my head around the concept of avoiding OV times for a change! :)

I am listening to my acupuncturist, honest :o It's just very difficult taking it easy when you don't get a moment to yourself in the day!

freelancegirl · 10/08/2011 12:06

Hi all,

Sorry to hear about your losses arianrhod. How lovely that Bupa can pay for Mr S! It certainly racks up going privately. Digi speaks wise words about the vits and the aspirin, and also waiting until you have had your results back from Mr S before trying again. It does indeed sound like you have a lot of history with autoimmune issues so that might well be what is causing the miscarriages.

Charting temps is a pain Kittens, I remember mine being all over the place. Next time (not being very optimistic about this pregnancy am I!) I am going to set an alarm every morning to be more consistent.

Thanks so much everyone for the good wishes at EPU. It certainly helped when I was sitting there in a waiting room full of bumps and babies and also then having to come back out there after another inconclusive scan.

The sac had grown and there is now a yolk sac - measurements were: 12mm x 7mm x 8 mm (compared to 11 x 5 x 8) on the 1st August. They think that is still in the '5 week +' mark which obviously isn't great in terms of being at an LMP date of 8 weeks and a possible ovulation date of 7 weeks.

Unfortunately though they say as it has grown they cannot totally rule it out and whip it out with an ERPC, so I have to wait for another scan on next Thurs. Sigh.

The only thing I wanted to go right with this one, if it was going wrong, was to make sure it all happened as early as possible. And it looks like that is not going to happen. Pretty damn sure it is not going to go right and just want to get it out of the way now.

Another problems is that it will be 4 weeks tomorrow since I had the last intralipids and on the off chance there could be something alive in there I don't think I have any choice but to go ahead with these tomorrow, just to make sure I have given it every chance. So there's a rather pointless, possibly fruitless £350 trip to Epsom.

Oh and sonographer thinks I have a normal shaped uterus so there goes the 'tipped uterus' straw to clutch at. So another week of waiting it is. I think I might as well hit the gin this weekend! But obviously got to stave off just on that tiny off chance.

OP posts:
digitalgirl · 10/08/2011 12:19

free oh honey (((((((((hugs))))))))), this must be so tough not being given a conclusive answer. They must have statistical reasons why they still think you have a chance.
I remember with my third MC - the pg was slow growing and also had a very slow heartbeat. Even though it had only grown 3 days in a week with a slow heartbeat they wouldn't agree to do anything while there was a heartbeat. I googled my chances and I think I still had a 20% chance that it would continue.
I think you should call Dr S and find out what the best thing to do is. Did you get print outs of the scan and measurements to show him? He may agree that intralipids is a waste of time and start weaning you off pred and tell you to stop the progesterone in case that is prolonging a non-viable pregnancy.
OR he may also think that you still have a chance and want to throw everything at it to help this pregnancy survive - in which case you may feel that £350 is money well spent at knowing you did everything you possibly could.

Arianrhod · 10/08/2011 12:23

Thanks for the welcome freelance and sorry to hear that you haven't seen what you wanted to on your scan :( (I've been following your story with interest :) ). It's an absolute nightmare having to wait another week for another scan, I do wonder sometimes if all this isn't visited upon us to teach us patience ... hasn't worked with me so far!

I don't have many words of wisdom I'm afraid other than hang in there, think positive thoughts (which as far as I can tell you're very good at anyway!), and hope someone invents a time machine today so you can jump forward a week and find out your answer quicker! :)

freelancegirl · 10/08/2011 12:53

Thanks Digi, I have emailed the office to see what they say. If they don't get back to me by later I will give them a call.

OP posts: