Single parent here and have been most of my working life.
It's absolutely doable, but definitely not easy. I have no family here and my friends don't live in my area.
I teach, so holidays were never a concern (other than the odd week which didn't overlap when I worked in a different county to the one my kids went to school in).
Between nurseries and childminders, I found the latter far better for childcare. More reliable, more common sense (wouldn't call me out of work for a single loose nappy, for example - the nursery was terrible for that) and usually a bunch of them trading kids between each other to cover holidays. Also, better opening times - I can drop mine off at 7am and collect at 6pm, and more flexible in that I could pay extra to cover parents' evenings.
I currently use a mixture of childminder for the morning and after school club (which closes at 6, or 5pm on a Friday).
I am now a high earner and in middle management, so receive no help, but worked my way up there. When I started teaching, my salary was low enough to receive tax credits, which would cover most of the childcare fees. It was really tough around 30k when this suddenly dropped off a cliff edge, and started getting better again as the kids got older and needed less childcare. Now it's only the youngest, and they're at school, so wraparound care is around 400 a month, which is doable.
Money has always been tight, so we don't live in luxury, but I earn enough to have been able to buy a (shitty and cheap ex council) house. I drive a 20 year old car which does its job.
I cook from scratch most days. The house is looked after, but never in a way that I'd be able to invite a friend in without having to do a huge clean and tidy beforehand. I still have hobbies, but they take a backseat until the holidays arrive.
And so we get by.