To wonder if there will be any fall out from skinny jabs?

[TheLemonGuide]

Everyone I know is now suddenly very slim. Okay, im exaggerating slightly, but genuinely, most of my friends who were previously overweight are all now slim thanks to skinny jabs. I am delighted for them! It seems unbelievable to think that a jab can cure this obesity crisis, but I am so pleased my friends and a couple of family members are able to live a healthier life thanks to this.

My only slight concern is, is this something that is going to be too good to be true? Do you think there will be any long term repercussions, or are we right to just celebrate this medication as a cure for something that so many have been battling for so long?

Fortunately they are likely to get cheaper long term, though may take a few years in the UK.

It is your choice and I am sure fine if you are only overweight. If you were obese despite trying to control weight with diet and exercise I think the benefits of weight loss drugs are very likely to outweigh risks for most people.

And that's why it's here to stay. Just like the crappy food and capitalist greed that made it necessary (and off-the-scale profitable) in the first place.

Yes, the price of these drugs will be much lower when the patents run out.

I think people tend to be thinner if food is "crappy". That is why people were mainly thin in the 70s and 80s. Plus smoking.

I mean, probably? It’s all still evolving.

My doctor recommended them to me a few years ago (3?) but it was out of my budget so I’ve shelved it. I’m strongly considering it now, but ideally I’d like to use them as a kickstart.

I’m very concerned about how it will affect your appetite once you want to come off them, though.

Not comparable at all.
Fen-phen had a relatively short research period, unlike GLP1s which have already been used for 20 years without terrible results.

I’m not sure there’s tooo much risk of the jabs themselves as they were already used for diabetes.

I think - as others have said - it’s more the risk of rapid weight loss. A lot of people may struggle with bone density issues and struggle with overall strength. Unless they exercise safely of course and build in strength exercises.

I also worry about those with eating disorders who are using the jabs without proper support. Weight loss can become addictive and so it’s more the extremes that may be a concern.

i think if you’re sensible then it’s more a wait and see!

interesting the types of responses on here though - I think you can tell who uses jabs! Some quite defensive ones. It’s seems so prevalent now though so I’m sure it must be safe. And great for those who have really struggled

I inject myself with a triptan medication when I have a migraine. None taught me how to do it I just collected the prescription and read the instructions. None one has ever checked whether I’m doing g it correctly or if I’ve had any problems with it.

Great. But people who are not obese are not being prescribed GLP. There’s a strong link between being overweight and developing psoriatic diseases but there’s also a high discontinuation rate.

There is absolutely no research on using GLP-1 medications for people with psoriatic diseases who are not overweight and not diabetic.

Gutted. My app only showed me up to "j" in the title and I clicked on this looking for some interesting speculation on potential fallout from skinny jeans.

They are for some long term oncology drugs.

While these jabs have been around for a long time, it’s the dose and way they are used now that means there are new safety concerns.

How does you taking them help this poster?

In my (amateur!) opinion, it's a great way for obese people to kick start weight loss. I think, if I'm honest, what feels a bit uncomfortable to average people like me who have felt fine as a size 14.... is when people on WLJ 'overtake' us and become a size 8. It feels a bit like it's shifting the centre point and what used to be average will now be pitched as a large size. Also, I think a size 8 always used to be unusual and was mainly people who were naturally very petite.
I don't know, maybe I'm being unfair and I'm sorry if what I've just said offends anyone. Feel free to pull me up!
I'm just musing on it and being utterly honest, and I think others might secretly feel the same. I guess it's the thought of 'why can't those on WLJ stop at a 12 or 14 cos that'd look fine?!' Maybe it's just my own insecurity coming out though, and I'm jealous and want to be thinner!

Because hunger is so fundamental to an animals survival. Yes, messing with it will give amazing short term weight loss but in the long term one needs hunger to tell the body to take in nutrition to sustain healthy life.

Many people with gastric bands only suffer the consequences of nutritional deficiencies 15 - 30 years down the line by which point they are very messed up and few doctors ever join the dots. The same will happen here with these jabs.

I think when used for the right reasons- as in tacking obesity and health issues - then yes they are great , from what we see so far .

The dangers , I think, are when they are used for vanity reasons and more specifically, not regulated.

I know of someone using them who was not overweight. She was carrying a bit of weight , yes , she had not long had a baby. She purchased the jabs online and lied about her starting weight. She is now VERY skinny . The most concerning part of this is that she has a history of eating disorders - to the point she was sectioned and had to go to a rehab centre. That is extremely concerning.

I got better instructions on how to inject Mounjaro than I did when A&E sent me home with a bag of insulin after an emergency diagnosis of diabetes. As you say it’s really not something that needs teaching and checking, it’s a tiny needle into a squishy bit of belly or thigh, no need to find a vein or do anything special just wind, stab and press.

Twice daily insulin and max dose of metformin didn’t lower my sugar levels anywhere near as well as a once a week jab of Mounjaro. Everyone thinks it just stops you being hungry but it’s bloody brilliant at increasing insulin production, increasing insulin sensitivity and reducing glucose production by the liver. Not being able to break down sugar leads to it being stored as fat to get it out of your blood stream.

Unlikely as people in the 70s & 80s mostly still ate real food. Yes, processed food was a thing but not on the scale we see today.

People also tended to cook exclusively back then. Eating out was rare and nobody got a Macdonalds sent in a taxi to them.

Taking WLIs doesn't mean you don't experience any hunger, though. So even if you were right that people need hunger cues to take in nutrition, which you're not, the premise would be wrong.

You've also left out that some people's hunger cues make them obese. Which lead to actual known health problems as opposed to a vague prediction of problems 15 years hence. Any argument that altering hunger cues is bad needs to address this.

New Research has shown that they’re excellent for heart disease- more benefits than just weight loss.

They turn the reward pathways in the brain down….
so I predict they will be used for addiction sufferers as well soon

i also read about a liver trial that was done and the trial was ended early as the results were so great that the study was considered non-ethical for the placebo group.
so I think it will be used for different things across the the next ten years than just weight.

it certainly has some potential downsides in metabolic function & for those who don’t want to use it forever.

I think you're being extremely honest, and it's telling that you're thinking of the whole thing in dress sizes rather than weight or health. You're not unusual there.

I lost a significant amount of weight some years ago and have kept it off since then with a few caveats (couple of pregnancies, a bit of fluctuation but never got anywhere near my heaviest again and healthy weight now). I don't see this as a moral issue at all. I've been able to do it the natural way, great, I don't need to spend money on jabs or take any kind of substance, lucky me. (Could not have done it without a hugely supportive husband though.) I really couldn't care less if other people take a different route. I was able to do it the boring way, not everyone can, it's nothing to do with me, my body or my health or lifestyle. I lost weight for me and others lose weight for them.

It's no different to someone passing their driving test on a crash course while I spent years on and off until I managed it. There's no moral value in it.

I injected myself with steroids before treatment for cancer, chemotherapy! No training at all!

I imagine that the consequences of my BMI remaining at 61.3 would have been far worse than any consequences of mounjaro might be. I am now down to 28.1 and still slowly, steadily losing weight with every intention of remaining on a low dose for the foreseeable. MJ has absolutely and completely changed my life. (edited for typo)

It’s literally one of the main mechanisms by which these drugs work. I’m not saying it stops hunger entirely but it artificially induces satiety.

People become obese because they eat the wrong food - too many processed carbs, sugar and industrial seed oils which rocket insulin. Over time they become insulin resistant and a symptom of this is high blood sugar and weight loss. Yes, there are rare genetic reasons but 99.9% of obesity today is due to insulin resistance by consuming the wrong foods.

My prediction isn’t vague, it’s based on science and medicine failing to learn lessons.

Medicine should be asking, how did we get here and what is the root cause we need to tackle?