To wonder if there will be any fall out from skinny jabs?

[TheLemonGuide]

Everyone I know is now suddenly very slim. Okay, im exaggerating slightly, but genuinely, most of my friends who were previously overweight are all now slim thanks to skinny jabs. I am delighted for them! It seems unbelievable to think that a jab can cure this obesity crisis, but I am so pleased my friends and a couple of family members are able to live a healthier life thanks to this.

My only slight concern is, is this something that is going to be too good to be true? Do you think there will be any long term repercussions, or are we right to just celebrate this medication as a cure for something that so many have been battling for so long?

I wouldn’t take them and I’ll be totally honest, I do think it is a bit lazy, at least for a large percentage of people who don’t have underlying health conditions that genuinely impact their ability to lose weight naturally. I do think for a small percentage of people they are necessary but there are a lot of people taking it because the perceived disadvantages (feeling sick, bowel changes, etc) are more palatable than the disadvantages of hard work (getting up earlier to exercise, taking time and money to cook balanced meals). I definitely see that for some people who are very large, kick starting their journey with the jabs is very much needed as it must be difficult to exercise when very unfit.

It is hard work to maintain a good figure so I can understand why people who prioritising cooking healthy meals, exercising regularly and reducing alcohol feel somewhat frustrated. Obesity is a modern problem that we are treating by a modern method, increasingly we all have less time to cook and exercise (cheers capitalism and cost of living!) cost of healthier food is more expensive than convenience junk, etc. We all know we need to move more and eat less but it is easier said then done!

The long term effects will hopefully be good ones. I think there will be a much lower prevalence of cardiovascular disease and diabetes.

There is no clinical trial which has demonstrated the long term (20+ years) safety of these jabs. They work incredibly well but the safety is questionable even in the short term. I know of someone hospitalised after taking it for only a few weeks.

Those taking them right now are the ginuea pigs testing the long term effects of these.

Overcoming the hard wire that regulates something as fundamental as hunger cannot be a good thing long term and it’s a disgrace to see big pharma pushing this and medicine accepting it. They should be reserved for the most severe cases of morbid obesity.

only "slightly" exaggerating????

Why can't it be a good thing? The explanation for this opinion is missing.

oh look its Judgey McJudge face....and for context yes I am overweight, no I would not use wli

None of us can answer that with any certainty. As with all healthcare interventions, it's risk vs benefit really.

Are you? Are you really happy for them? Or a bit peed off and desperate for there to be a downside so they can go back to being your fat mates?

I don’t think it’s “Judgey McJudge face” (how childish) to have an opinion. It is my opinion and I too have struggled with my weight, I’m not sharing my opinion as someone with a perfect body, I am far from it. I have huge food noise and love to emotional eat so I totally get the pressures but I still think as a society we have over complicated weight loss.

The long term safety of drugs are never assessed via 20 year long clinical trials. Safety is assessed via observational studies and there have been plenty on these drugs as they have been around for about 20 years for diabetes.

Research so far suggest some long term issues. There are some cancer risks from animal studies (which have not yet been confirmed in humans) and there are issues with bone density, especially if patients lose weight fast and don't take precautions (weight bearing exercise). There are some kidney issues associated with dehydration from poorly handled nausea and vomiting. And a few other conditions in a small minority of patients.

When taken by over 65s there are increased risks of fracture, and in men losing significant body weight rapidly, an increased risk of higher overall mortality.

The there's the whole issue with weight regain and the need to find good maintenance programs (possibly through intermittent use or "micro-dosing").

But overall, the medications appear to slow molecular aging and the health side affects look like they'll be positive for the population and take pressure off the NHS (over and above the impact of lowering obesity rates.)

If you are obese I would take them.

Yeah I do worry about the long term side effects. Whenever I’ve looked into it (out of curiosity mainly, I’m a size 12 who would rather be a 10 so am planning to swim that off in the next few months while eating healthily) it hasn’t felt like enough data for me. Saying that I can see how the health implications of being obese for many patients outweigh concerns re side effects (as observed so far).

I worry about fertility tbh, and I worry about the possibility of birth defects. Some worrying stuff about the pancreas, too. And most people seem to put the weight back on when they come off it, so that isn’t great, either. People tell themselves they won’t fall back into bad habits (like me post-breastfeeding and back in my size 10 jeans) but it’s really hard in practice.

There is evidence that you can't just take them, lose the weight and then stop taking them. The weight goes back on faster than on other weight loss regimes. So some people will be very pissed off that they regain. Others will be very pissed off that they have to keep taking the injections.

I am no longer obese. I am thin.
GLP stopped my skin psoriassis immediately.
I am off the psorratic arthritis drugs completely ........drugs with much more serioys side effects than mounjaro incidentally.
No more naproxen for pain either.....another drug known to cause strikes and heart attacks.

Oh and my blood pressure lowered to healthy immediately.

The research may be limited now. It wont be for long.

Personally I wouldn’t take it - I need to lose 3 stone but too scared of the long term damage to your organs.

I had an immediate improvement in certain chronic things that I’d suffered with for 30 years.
When I mention it to people they say of course, you’ve lost weight, duh! But I lost significant weight 15 years ago (then put it all back on and more) and had no improvement whatsoever. This time the pain and inflammation was gone within a few days.

OMG, that could swing it for me. Psoriasis is ruining my life and I’d rather take WLI than methotrexate

I would say that thinking people who use wli are "lazy" is definitely judgemental.

You lot would absolutely love for there to be some terrible side effects of weight loss jabs.

Exactly!

I’m not obese but I’d definitely class myself as overweight. I won’t be taking weight loss injections but I will be exercising and eating accordingly to drop the weight. That’s my choice and it’s great that people can make the choice that best suits their situation and values.

Not unreasonable it takes a long time to link up negative effects to medications and longer to decide whether to do anything about it.

Remember phentomine? The miracle weight loss drug of the 90's. Not so popular when it was linked to heart attacks.

I hope no significant side effects are ever found (inevitably there will be some people who can't take them or have a bad experience but I mean in a significant measure so that they aren't considered generally safe). Mostly, of course, because I want people to be healthy, well and happy, but also in huge part because I want to see what these people do when they can no longer pretend they're just so very concerned.

Not getting cheaper by the day in my experience 😆 and plenty of people regaining when they stop and unable to afford to be on them long term. I think it’s starting to dawn on people that for most, it’s a long term or even life long treatment, so I think there’s going to be an increasing rich/poor divide between those who can afford to be on them and stay on them, and those who can’t.