To wonder if there will be any fall out from skinny jabs?

[TheLemonGuide]

Everyone I know is now suddenly very slim. Okay, im exaggerating slightly, but genuinely, most of my friends who were previously overweight are all now slim thanks to skinny jabs. I am delighted for them! It seems unbelievable to think that a jab can cure this obesity crisis, but I am so pleased my friends and a couple of family members are able to live a healthier life thanks to this.

My only slight concern is, is this something that is going to be too good to be true? Do you think there will be any long term repercussions, or are we right to just celebrate this medication as a cure for something that so many have been battling for so long?

Feel you may being disingenuous in this and your subsequent post - a 3 second google makes it very clear that you have to have a certain BMI to be prescribed them.

But I’ll bite. As a result of loosing weight: my thyroid medication has been reduced, my cholesterol levels which were approaching unhealthy levels are all optimal as are all my other health indices per a full blood count (ie liver function, kidney function etc, all if which fluctuated and were often in the borders of abnormal on testing). My BP is lower, my resting heart rate lower and my recovery rate after cardio exercise (measured by heart rate) is quicker. I no longer have lower back pain, nor knee and hip pain. I no longer get headaches like I used to - migraine specifically seems to be reduced from 2-3 days a week for years to 2-3 a year now, and milder in acuteness (observed in my DS too). I sleep better as I no longer snore [so my DH also sleeps better 🤣]. My bladder control due to post natal pelvic floor weakness (and surgery) is somewhat improved so I am now able to seek alternative treatment for this when I was looking at a second culposuspension surgery. I used to self medicate for stress/anxiety/depression with alcohol but was completely unable to tolerate drink at all for the first year, and now can responsibly enjoy a single drink a few nights a week. My depression/anxiety, while not completely gone, are manageable without medication.

My risk of heart disease, according to the little NHS algorythm/app that my GP used, is on a par with an average woman of more than 20 years younger than me as as result of all the stuff above.

Studies suggest that these medications if taken longer term may mitigate the severity and/or development of multiple other diseases (list attached). I am particularly fearful of neurodegenerative illness such as Alzheimer's/dementia, so very keen to see what current and future studies can tweeze out. As a hypothyroidism sufferer - and related inflammatory illnesses which have lead to frozen shoulder requiring surgery - am also keen to see the effects I have personally felt on these meds being explored and explained in studies too.

Key Conditions Potential Benefited by GLP-1 Agents:

• Cardiovascular Disease: They are approved to reduce the risk of cardiovascular death, heart attacks, and strokes, particularly in patients with type 2 diabetes.
• Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD/NAFLD):They help reduce liver fat and improve inflammation in patients with metabolic liver disease.
• Chronic Kidney Disease (CKD): They have shown the ability to slow the progression of kidney damage and reduce complications associated with kidney disease.
• Heart Failure: Specifically helpful in treating Heart Failure with Preserved Ejection Fraction (HFpEF).
• Obstructive Sleep Apnea (OSA): Approved as a treatment for reducing breathing interruptions in adults with obesity.
• Osteoarthritis (OA): They are associated with reducing joint pain, partly through weight reduction and partly through anti-inflammatory pathways.
• Addiction and Substance Use Disorders: Emerging studies suggest they may help reduce addictive behaviors, including smoking and alcohol use, likely by impacting dopamine pathways associated with cravings.
• Polycystic Ovary Syndrome (PCOS): They are being investigated for reducing insulin resistance and aiding weight loss in PCOS patients.
• Neurodegenerative Diseases: Preclinical data suggests potential for managing Alzheimer’s and Parkinson's disease due to the role of GLP-1 receptors in brain function.

Hope this is enough to be getting on with for now…

I bumped into someone at the gym the other day who commented on my weight loss (3st 2lbs courtesy of the WeightWatchers app). I knew she had lost of weight using MJ. She lost 4st on MJ, stopped using it, gained the 4st back, and now has to stay on it for the rest of her life, despite it making her feel nauseous all the time. She has terrible trouble with food noise, so this is the only option she has.

I have to lose weight due to MASLD (metabolic liver disease), but I know I will have to continue with the WW app even when I reach my goal weight because otherwise it will be too easy to slip back into old eating patterns.

Gosh; my apologies.

A couple of years ago, a diabetic friend of mine was put on MJ by her diabetic nurse. A few months later she was booked in for an urgent cholecystectomy due to a blocked bile duct. Prior to this she had no gallbladder issues at all. I know these days you can't be prescribed MJ if you have gallstones. She may well have had them beforehand, but been unaware of the fact.

I’ve been taking a really low dose. I wasn’t massively overweight, but health issues from labour and other things has really stopped being as active as I was.

It has helped curb the constant need for me to eat. I don’t snack anymore. And because I can’t eat a large portion, I’m more mindful of what I’m eating, to make sure I’m getting the nutrients I need. Food noise is something I’ve struggled with.

I have been taking it for 6 weeks. Lost just over a stone. I’m taking half the normal start dose. And I’m not going to increase it. As I just need to maintain really.

And both being overweight and losing weight quickly can cause gallstones. It’s one of those things you can’t win whatever you do.

That’s all well and good. Healthier heart, liver bla bla bla…

But what about if you get wrinkly skin? 😳

Spanx and cheek filler?

ETA the hosiery version of spanx… not the naughty variety 🤣

Was tempted to post a pic of a nearly 60 yo woman after 6st weight loss and the, erm, supposedly wrinkly skin but can’t work out how to block the eyes or something to prevent a reverse image search.

And why do I care what you think? I pay for mounjaro. I was 20 stone. I am now 16 stone.

• I have lost an average of 1lb a week. This is not rapid.
• my blood pressure is reduced
• my diabetes is under control
• my eating is massively changed
• I exercise every day
• I have an older face and loose skin of which I am proud - war wounds, a reminder of how far I've come and the battles lost to get this point
• most importantly I can dare to think I will know my grandchildren children.

Curve without loose skin is not for me. I hope to be healthy and if that means loose skin, so be it.

That's such a strange response from your Dr. Yes weight-loss can cause gallstones but after you've had surgery surely you're no longer at risk? Or is there something I'm missing (I've had mine out years ago - possibly brought on by weight loss but not WLI and not fast weight loss)

If you want to wear a bikini, wear one. You don't owe the world a 'beach ready body' and in my experience once you hit middle age, no one notices what you look like on the beach anyway. The middle-age invisibility cloak is a marvellous thing.

Sorry but that really isn't correct. Most drugs have side effects, some of them very serious, however responsibly they are prescribed and taken.

People, like my previously normal-weight friend with the lengthy history of bulimia, are just getting them off the internet somehow.

Fair. I didn’t express what I meant very well there. I just meant it’s no different to any medication in the respect that if you take it as prescribed then there is no more to worry about than any other medication. No one is sitting about angsting over the potential side effects of paracetamol. Because people accept that the risk when used correctly is outweighed by its effectiveness.

And that’s a regulation issue, not a drug issue. If they made it more easily available on the nhs for the people that can benefit from it hugely then people like your friend wouldn’t have e such easy access.

How are you taking half doses?

Thalidomide was 60 years ago now, and an awful lot was learned from that horrific mistake. Same with smoking. It was a long time ago.
Glp-1s have been in use for 20 years in diabetic patients, and in development since the 80s. It didn’t just turn up 5 minutes ago and then they started handing it out like smarties.

I aware of the class action lawsuit, yes. Bringing the lawsuit doesn’t mean GLP1s are responsible though, that’s yet to be proven.
Diabetes itself causes gastroparesis. Usually any gastroparesis caused by GLP1s is temporary, not so when it’s diabetes.

also, do you know how many class actions are in motion against different medications? Hundreds. Are you as worried about those?

As with all medications there’s risk of side effects of varying severity.

Sure there could be. Plenty of drugs turn out to have side effects once they are being used more widely, or for a new purpose. So that's very possible and there are already some indications of what kinds of issues might arise.

What I think may be inevitable and is already happening is cultural fall out. We see what's going on in Hollywood and that tends to push overall beauty trends. Increasing normalisation of disordered eating. More pressure on those who are heavy to medicate.

Well Done for calling these skinny pills out..in a humourous way.

Rennie will neutralize anything They also taste vile.
.Not enough research done on these wonder weight loss pills.

Big scramble by Big Pharma to cash in Big Time

There is a whole world outside the UK and the NHS.

Making it more available in the NHS would not stop women of normal weight getting their hands on it by other means, whether by online pharmacies, sympathetic GPs, or some dodgy website cashing in.

The people requiring gallbladder removal were using it as prescribed. The people who suffered irreversible blindness were using it as prescribed. The people whose colons ruptured who now require a colostomy bag for life were using it as prescribed. The people with gastroparesis and ileus were using it as prescribed.

There are warnings of these adverse effects on the product information sheets put out by the drug companies who manufacture them (NAION is yet to be added, I believe) and they are warnings for those who are using them as prescribed.

A good friend of mine took the contraceptive injection for years and now has a brain tumour linked to this (I don’t believe that this has much publicity but is very real for a lot of women). There is bound to be side effects and risk with WLI, I agree that it will be interesting to see what these are and if they are serious in the future.