Yes you can afford it in principle and still have lots of leftover income.
However, whether you can afford it in reality is different.
If it's a large house then the utility bills will be significant, as will council tax and insurance; especially if the property is worth over £1m.
Larger houses require proportionally more maintenance - e.g. more rooms to decorate, more bathrooms to keep fresh and modern, a larger kitchen to replace, more radiators, a bigger boiler, a larger garden, more fence panels. You get the picture.
Does it need a refurb or any construction work? That is hugely expensive now compared to five years ago.
What else do you spend your money on? If you also like several long-haul holidays a year and have expensive hobbies or love high-end cars or eat out often or have posh gym memberships and PTs then clearly you need to budget for those and your lifestyle may not allow for a larger mortgage.
What are your long-term financial aspirations? If you wish to retire early or develop a passive income or set your child up with a home then you may be wiser to go for a less expensive home and invest money elsewhere. That's something to speak to a financial advisor about.
Finally, are you happy to take on a large mortgage with the risks involved (e.g. if one of you were to lose your job/become too ill to work). That will depend on your own appetite for risk.
As others have suggested it's certainly worth going through your bank and credit card statements and seeing what you actually spend versus what you think you spend. I'd also strongly recommend speaking an independent financial advisor to ensure your lifestyle and appetite for risk marries with your financial goals. You're in an extremely privileged position financially so make the most of it!