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AIBU?

Share your dilemmas and get honest opinions from other Mumsnetters.

Original poster

Sertraline 14 days positive stories please

169 replies

Francis24 · 23/04/2025 13:25

How long before sertraline made you start to feel better depression? I've been taking it 14 days 25mg positive stories please

OP posts:
Hillsmakeyoustrong · 30/04/2025 20:18

Thinking of you @Francis24 x

Original poster
Francis24 · 30/04/2025 20:29

Hillsmakeyoustrong · 30/04/2025 20:18

Thinking of you @Francis24 x

Aw thank you x
I'm feeling a lot better tonight. I feel like a different person on an evening since Saturday. It is the morning and day time which is bad still. I'm hoping that will improve soon. The evenings are so different!
Thank you so much and hope you're ok xx

OP posts:
Hankunamatata · 30/04/2025 20:39

Hang on there. 50mg is my maintenance dose qnd has been for years. I'm just not a nice person without it. Times of high stress I move to 100mg for a period. Obviously with doctors permission

NippyNinjaCrab · 30/04/2025 20:52

Keep hanging on lady, one day the low just won't seem as black and bleak. Hugs xx

Hillsmakeyoustrong · 30/04/2025 21:03

Cortisol levels are at their highest in the morning (so I was told!) and my anxiety was always raging in the mornings. But also when are you taking the tablet? Morning or evening?

ColdTofuSandwich · 01/05/2025 00:16

i know I’m getting better when it lifts in an evening. That will hopefully get gradually earlier as the medication takes effect

Original poster
Francis24 · 01/05/2025 10:06

ColdTofuSandwich · 01/05/2025 00:16

i know I’m getting better when it lifts in an evening. That will hopefully get gradually earlier as the medication takes effect

Thank you. So when you were getting better, did it start more on an evening? Did it eventually get earlier in the day too?

OP posts:
Original poster
Francis24 · 01/05/2025 10:07

Hillsmakeyoustrong · 30/04/2025 21:03

Cortisol levels are at their highest in the morning (so I was told!) and my anxiety was always raging in the mornings. But also when are you taking the tablet? Morning or evening?

Hello 👋 in the morning, around 8am as I was sleeping at all before. Is it better to take at nighttime for morning anxiety?x

OP posts:
Original poster
Francis24 · 01/05/2025 10:07

NippyNinjaCrab · 30/04/2025 20:52

Keep hanging on lady, one day the low just won't seem as black and bleak. Hugs xx

Thank you x

OP posts:
Original poster
Francis24 · 01/05/2025 10:07

Hankunamatata · 30/04/2025 20:39

Hang on there. 50mg is my maintenance dose qnd has been for years. I'm just not a nice person without it. Times of high stress I move to 100mg for a period. Obviously with doctors permission

Thank you x

OP posts:
ColdTofuSandwich · 01/05/2025 10:31

Yes exactly that. I felt better of an evening - not 100% but better, and that feeling gradually gets earlier in the day. I’m a good 10 days into that at the moment and I’m still struggling in the morning but it does pass quite quickly

Original poster
Francis24 · 01/05/2025 11:31

ColdTofuSandwich · 01/05/2025 10:31

Yes exactly that. I felt better of an evening - not 100% but better, and that feeling gradually gets earlier in the day. I’m a good 10 days into that at the moment and I’m still struggling in the morning but it does pass quite quickly

What dosage are you on and for how long?

OP posts:
ColdTofuSandwich · 01/05/2025 12:25

I have changed my meds to sertraline so am slightly different to you. I’m on 150mg and 8 weeks in.

ColdTofuSandwich · 01/05/2025 12:26

But two weeks on 150mg dose

WhereIsMyJumper · 01/05/2025 12:29

Not sertraline but I was on another SSRI. I was lucky in that the negative effects in the first weeks were minimal. I remember about week three all of a sudden having a positive thought pop in to my head. Like everything was going to be ok, so I think that’s when I first started feeling better. Then started feeling better and better and peaked around 3 months.
I came off them a year later with no ill effects and haven’t needed them since. Good luck.

abracadabra1980 · 01/05/2025 12:34

Sertraline was a life saver for me - started on 50mg then upped to 100mg. The first 2/3 weeks are pretty rough but stick with it, you're through the worst now. Good luck X

Original poster
Francis24 · 01/05/2025 13:09

abracadabra1980 · 01/05/2025 12:34

Sertraline was a life saver for me - started on 50mg then upped to 100mg. The first 2/3 weeks are pretty rough but stick with it, you're through the worst now. Good luck X

Thank you for this xx😊

OP posts:
Original poster
Francis24 · 01/05/2025 13:28

ColdTofuSandwich · 01/05/2025 12:26

But two weeks on 150mg dose

How soon after the morning does it pass for you?

OP posts:
ColdTofuSandwich · 01/05/2025 13:39

Couple of hours maybe? Much better if I get up as soon as I wake up - if I go back to sleep it’s harder to get going

Hillsmakeyoustrong · 01/05/2025 14:56

Well no not necessarily. I think I'm trying to figure out why you feel better in the evenings. If it's because the meds have had time to kick in given they need replenishing every 24 hours but then are you sleeping though the benefit?

I take them at nighttime because they make me sleepy and at the beginning it meant I slept through the worst of the side effects. And I wonder if they are optimal in my system for the mornings which is when I was most anxious.

I don't think there is a right or wrong time tbh but you do have to take them at the SAME time. I really notice if I don't! X

Hillsmakeyoustrong · 01/05/2025 14:57

But it's still early days so I'd stick with what you're doing and trust you'll feel the full benefits soon enough 🙏

Original poster
Francis24 · 01/05/2025 15:44

Hillsmakeyoustrong · 01/05/2025 14:56

Well no not necessarily. I think I'm trying to figure out why you feel better in the evenings. If it's because the meds have had time to kick in given they need replenishing every 24 hours but then are you sleeping though the benefit?

I take them at nighttime because they make me sleepy and at the beginning it meant I slept through the worst of the side effects. And I wonder if they are optimal in my system for the mornings which is when I was most anxious.

I don't think there is a right or wrong time tbh but you do have to take them at the SAME time. I really notice if I don't! X

Yeah I take them around 8am so Early morning around 6ish I feel terrible. So that would mean the tablets are nearly out of my system by?

OP posts:
NippyNinjaCrab · 01/05/2025 15:53

Hillsmakeyoustrong · 01/05/2025 14:56

Well no not necessarily. I think I'm trying to figure out why you feel better in the evenings. If it's because the meds have had time to kick in given they need replenishing every 24 hours but then are you sleeping though the benefit?

I take them at nighttime because they make me sleepy and at the beginning it meant I slept through the worst of the side effects. And I wonder if they are optimal in my system for the mornings which is when I was most anxious.

I don't think there is a right or wrong time tbh but you do have to take them at the SAME time. I really notice if I don't! X

I take my Sertraline in the morning and always have done but I take the quetiapine as directed at night because of the racing brain. My DH has just started Citalapram and I said to take it at night in case of side effects etc but the MH nurse said today to take it in the morning, I feel bad now but I thought it would be better. I just didn't want him to feel rubbish with side effects. Xx

ColdTofuSandwich · 01/05/2025 17:11

It’s quite common for anxiety to be at its worst in the morning - it’s when cortisol is at its highest.

I have always taken my anti depressants before I go to bed but they do effect different people in different ways

Original poster
Francis24 · 02/05/2025 11:37

Hello. I received some upsetting News yesterday, and since then I have been in a high state of panic and anxiety. The doctor did say sertraline can increase anxiety and panic in the beginning and after upon a dose until the serotonin levels. I guess I'm just wanting to hear if the same happened for anyone?

OP posts: