It's a lottery, pure and simple.
Multiple likely factors including genetics and environment.
My cancer list:
DP - undiagnosed and virtually symptomless oesophageal cancer that metastised to his liver, lungs and brain - which caused catastrophic bleeds and took him out in three weeks. Only diagnosed post mortem.
DM - ovarian cancer (and / or peritoneal / omentum as it was only diagnosed at stage 4 because doctors dicked around putting her on the Fodmap diet for two years as they thought it was IBS. Picked up after a blood test when her GP thought HRT might help with her tiredness. She was 72 at this point)
DMs sister - ovarian cancer.
Step-father - liver cancer secondary to stomach cancer. Dismissed as constipation until he got referred shoulder pain.
Paternal GM - third bout of breast cancer finished her off about a week before her 90th birthday.
Paternal Aunt - breast cancer took her in her 60s.
Close family friend - bladder cancer - dismissed as anxiety until it was too late.
Another friend - survived lymphoma and in remission just shy of 30.
Friends partner - died of breast cancer about two months after my DP.
Very close friend diagnosed breast cancer a few months after DP died - fortunately in remission now.
DF has splenic lymphoma which is unlikely to finish him off as it's a slow one - he's going to be 84 in October. Hopefully. He is a nuclear test veteran, for what it's worth.
I have had my ovaries and tubes removed by the NHS despite no obvious genetic fault due to DM and Aunt both having ovarian cancer. I'm still high risk for peritoneal and omentum apparently.
DPs dad survived his oesophageal cancer - it was picked up accidentally during investigations for something else. He's just turned 80.
His sister, in her 70s, lives with an inoperable brain tumour.
This evening a young friend of mine told me about two people close to her both with recurrent cancers.
Cancer is an utterly indiscriminate scourge.