Were I the hiring manager, I would want to know whether the person has the ability and the willingness to be a good worker in that role. If they have any physical characteristic that stands out (be they obese, skinny, tall, short, or anything else), I would just want to know that was not going to get in the way of doing the work and getting along with colleagues.
If you are the applicant then you can volunteer information to the hiring manager to reassure them on that, and if you are comfortable making light of yourself a little bit, then you can even turn it into a positive. For example, if the physical aspect involves carrying heavy things, something like this:
«I know this is a physically demanding job, from having had a similar role in the past. I actually have a lot of strength just from carrying all of myself around all day! I am really keen to put that to good use in this role because [reasons why you want to build a career and contribute in your chosen professional area]»
On the experience front, again as a hiring manager I would want reassurance that you can still do the job after such a long period, and I might be curious why you worked in different areas for 10 years and now want to come back to this area.
Employees who are self-motivated and competent are actually kind of rare, so if you are one of those and can make sure the hiring manager knows it, you should stand an excellent chance. Good luck!