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From bloodwise.org.uk/info-support/low-grade-non-hodgkin-lymphoma/symptoms
Tests to diagnose low-grade NHL
The only way to confirm a diagnosis of low-grade NHL is through a lymph node biopsy.
Lymph node biopsy
A lymph node biopsy is a minor surgical procedure that takes a sample of the lymph node affected by the cancer. This sample is then examined under the microscope in a laboratory.
This test may be done under general anaesthetic. You’ll often have one whole lymph node removed – you might hear this being called an excision biopsy. Increasingly a core of lymph node is removed under local anaesthetic with the help of an ultrasound or CT scan. This is called a core biopsy or incisional biopsy.
This is the definitive test that will confirm your diagnosis of lymphoma. After this test, your lymphoma will be ‘staged’ to understand the extent of the cancer.
Initial health tests
After your diagnosis, you’ll have more tests, which will give doctors more information about your health and the lymphoma.
Blood tests
These will give your healthcare team a full picture of your general health before you start any treatment.
Full blood count
A full blood count (FBC) measures the number of each type of cell in the blood: red cells, white cells and platelets.
Although the full blood count is often not affected in low-grade NHL, the test is still important. The FBC will help doctors spot if you develop anaemia (a condition caused by a lack of red blood cells which can lead to tiredness and breathlessness). Anaemia may occur because of your illness or your treatment. The FBC will also see if the lymphoma has affected your bone marrow and if this happens your treatment might be changed.