Does your potential new employer have flexible working arrangements, for example working from home on Monday and Friday? That would bring the "stay away" time down to 3 nights only (if you leave after 5 on Monday evening).
We moved about 180 miles from my base office in 2006, and this is more or less what I did, except I also had work elsewhere. People in my company don't need to be in their base office, there are 3 base offices + various non-base office locations where people work, depending on clients. I did it about 2.5 years, but in the summer I did work in one of those non-base locations chipping in with the local teams. Then I'd had enough and requested a base location change.
Currently, I'm away from home 2 or 3 nights per week, 2 or 3 weeks per month, sometimes every week (summers, usually) - but since my base office is only 25 miles away, hotel, etc, is paid for. My partner takes care of the house, so I have only my main things to do (laundry) when I get home.
I found (and find) the not having your things around the most difficult thing. I tend to work long hours when away, so go to bed early and start early. Most things I like to do in my spare time I can't do in a hotel room (music, cross-stitch (not enough light, usually)). So I mope around on-line and watch a bit of telly - caught a wonderful episode of DIY SOS several weeks ago. But it can get a bit draining.