People I know who can live anywhere, tend to live in beautiful places such as islands in Scotland, or by the beach. Not in northern towns
There are plenty of beautiful places on the outskirts of northern towns, so the best of both worlds. Even places like Burnley or Rotherham.
I took this photo a few miles outside Wakefield just last week. The town centre isn't particularly nice, but Leeds and Sheffield are very vibrant, with lots going on. You have lots of amenities and culture, but can be in real wilderness in under an hour or the coast in about an hour and a half.
Many people can easily afford housing. In this part of the country, we have just about everything most people could need. Including 4 national museums within less than an hour's travel.
Unless you have an income very much above the average, I fail to see how the quality of life in London and the South East can be significantly better. In fact it is probably worse for most people due to the cost of housing, congestion, pollution and overcrowdedness.