Not fair to split 6 ways. Equally wouldn't be fair to split per room.
I'm part of a group that has holidays like this regularly and as we are mostly mathsy geeks who like complex equations we don't mind using a complicated method and it works like this.
50% of the rental (effectively the "downstairs") and all the food and drink is split per head with babies counted as 0.25, kids age 2-14 counting as 0.5, 14-18 as 0.75.
The other 50% of the rental is split per room though bigger rooms with en-suite facilities or additional comforts counting as up to 1.2 rooms depending how luxurious they are and tiny or uncomfortable rooms being sometimes as low as 0.8.
Doing it this way means that some families of 4 will be able to spend a bit more for more space by having two bedrooms whereas another might choose to squeeze into one room to save some cash - but none of us would think it would be reasonable for the former family to pay double what the latter pay.
If you use this method and assuming that food and drink came to a total that was around half the total paid for the rental, and assuming all kids are in 2-14 bracket and the big room was a '1.1' and all others were a '1' then you would get:
Couples A,B,C and D (2 kids each and private room) = 18.3% of full cost
Couple E with 2 kids and only a share of a room:
= 16.1% of full cost
Couple F with no kids and only a share of a room:
= 10.1% of full cost.