I am thinking of going to a retreat to take ayahuasca, psilocybin, mescaline or iboga (not sure which yet) for psycho-spiritual therapy to treat my lifelong depression and anxiety which seems to be completely resistant to normal anti-depressant treatment. I have heard that psychedelics can reset the brain and give some clarity. I don't think this will be a panacea but I think it could help me and give me some breathing space from my incessant negative self-talk.
Has anyone done such therapy, what did you take and how effective was it?