I think the problem is that your averadge person in some forgotten northern town doesn't really care where those drugs and scientific breakthroughs occur, to them it doesn't make a difference if they happen in the uk.
And this highlights the problem of a yes/no vote on a complex question. EU membership has many effects and implications which are poorly understood by almost everybody.
Yes, your northern voter doesn't care about science or drug breakthroughs. If asked about the current science research budgets, they'd probably vote to cut them. (Despite the fact that science research is consistently shown to be one of the best returns for investment for a society: every £1 invested generates around £5 back on average, most of which enters the general pot of money i.e. returns from publicly funded research don't just make the rich richer.)
And it is directly relevant to these northern voters that breakthroughs are made in the UK. Not just in the obvious way, breakthroughs -> revenue -> more public spending, but also in terms of access to drugs and medical procedures. There are big fears that a hard Brexit is going to lead to time delays before we can access new drugs developed in Europe, for example. The European Medicines Agency
www.ema.europa.eu/ema/index.jsp?curl=pages/about_us/general/general_content_000091.jsp&mid=WC0b01ac0580028a42
is relocating from London and we are unlikely to retain access to it.
"Booting out" world leading doctors from the EU could mean that we could no longer offer certain new treatments in university hospitals due to lack of expertise.