We have nothing to do with my MIL. She is a cold, selfish, idle, dirty woman, who cares not a jot for her son or our children.
When I was expecting, I handed her my pregnancy scan photo as a surprise with a big smile. There was silence, no smile, no "ooooh" or "aaaaah" - absolutely nothing
. I thought that perhaps she didn't know what she was seeing (she did, I was 3 months gone, so the picture showed a fully formed baby!) and had to prompt her for a response. I got a "hmmmmm" and she handed it back.
She told me that my baby son (less than a year old) "likes violence" because he used to stop and watch a certain advert with zooming cartoons and a catchy tune. Nothing violent about it at all. 
She showed no enthusiasm or grandmotherly delight for a picture my DD drew her, which took her ages and she was so excited about giving it to her. MIL took the picture, looked at it, said "hmmm, yes" and put it on the table. No thank you, nothing. The look on little DD's face crushed me and I had a hard time holding my tongue and my rage.

When I mentioned to DH that MIL only ever contacted him if she needed something doing and her other children couldn't do it for her, he realised and we decided not to contact her or visit, just to see how long it would take for her to just want to see us. That was over 10 years ago - she's never phoned, texted, or visited in that time. She only lives 5 minutes' drive away.
The loss is entirely hers. She has missed my DC's childhood and their love, and she cannot abuse my DH's kindness and compassionate nature.
When we last saw her, her home was utterly filthy. She has never been houseproud in the slightest, and the worst was the state of the toilet. Defies description! I refused to let the DC use it as it was that disgusting. And I would give a heave or two when seeing the state of the kitchen. 