Humans were fine for millennia. We existed alongside other animals and didn't do too much to alter the balance one way or the other. Some people live like this still, but not many now.
I'm not saying we go back to that, as PP said people with even simple ailments would die/suffer e.g. short of a simple appendix operation.
I always remember the sheer disbelief expressed by native American Plains people when white hunters were shooting buffalo from trains.
https://blog.nativehope.org/how-the-destruction-of-the-buffalo-impacted-native-americans
Sadly, our progress in science, medicine and our affluent life etc came hand in hand with pollution, waste and exploitation of the environment, people and other animals. Gathering pace during the Victorian era, until here we in in late stage capitalism. Could we no undo the damage? Would we want to sacrifice things for a simpler, less materialistic life (and what?)
I don't think the majority of posters are misanthropists, I think they are realists in terms of our net impact on our planet.
Humans are massively clever (doesn't always show, and sometimes clever to the wrong ends), and it would be ironic if our ability to reason and organise becomes our downfall, I'd say that's tragic really considering our great potential to help solve problems for ourselves and the planet/other species.
To see how tragic this is isn't the same as being a nihilist.
From my point of view, I have a child and I would like him to 'inherit' a beautiful, amazing world that functions well for all.
I take conscious steps towards this, but I do think that the bigger players hold the cards - governments, multinationals etc and the chances of changing those, well I am not confident. They are partying on the good ship Titanic aren't they? And they don't care as long as the bubbly keeps flowing.
If Boris can say Covid is nature's way of killing off the old, god knows - they hold life pretty cheap.
Environmental disaster is nature's way of checking the global population? (Not my view but you can see a politician or two saying that)