MIL is the loveliest woman on the planet, but to a fault, and it drives me insane when she visits. She's too polite to so much as ask for a glass of water, so we always end up waiting on her hand and foot when she visits. Being 33 weeks pregnant last time she came to visit, I was somewhat grumpy about it and did in the end ask her why on earth she thought she'd be inconveniencing us by making herself a cup of tea. I had to really insist that she used one our towels when she'd forgotten hers and needed shower, fgs.
I much prefer guests to ask for things, get their own drinks etc and not be polite about small things that don't matter.
Other things that guests, in general do that annoy me:
Saying 'I don't mind' in response to ANY question about preferences - do you want to walk or drive to x place, shall we eat in or go out, do you want to do x or y. PLEASE JUST HAVE A PREFERENCE. I want to be a good host and accommodate my guests!
Constant chatting. Fine if you're in for a flying visit for the evening, but I'm an autistic introvert and incessant small talk for 3 days isn't my jam. Sometimes I just want to be quiet for half an hour.
Ignoring my requests to ignore the dog when they meet him - he's touch-sensitive and there are a few rules around petting that need to be explained before people go bombing over to him for cuddles. He has growled at multiple guests who have ignored those boundaries and been way too touchy feely with him.