Absolutely not he won't be anywhere near mature enough to cope alone on an emotional level even if he can on a practical one.
He's still very much a kid and you are the parent (I think - you're not being clear on this) therefore what you say goes whether he likes it or not generally it's a teens job not to like what you want them to do
He can either go with you or stay at grandparents
Any number of things can go wrong, from simple loneliness to running out of money for food, to unexpected visitors in the shape of tradesmen/cold callers (which could include con men or potential burglars) etc that he doesn't know how to handle to him or friends/acquaintances of his realising he has an "empty" and throwing crazy parties where your home gets wrecked etc to various accidents and emergencies from slip and falls to full on house fire.
He's too young to be expected to deal with or bear the burden of responsibility for anything like the worst ones.
I've experience in a voluntary capacity over several years with kids this age and they THINK that they can handle an emergency situation and I've even trained them on some actions but on an emotional level they can't always in fact rarely.
When it actually happens they panic and their brains freeze.
I've seen this many times and I'm not even talking major emergencies I'm talking sprains and strains from falls or breaking something they perceive to be expensive/they'll get into loads of trouble for breaking!