He's in an industry where anyone could crash and burn at any point. As far as I can tell, with acting/celebrity you're hot, and then all of a sudden you're not.
I'd say he's making hay while the sun shines.
I agree that he sometimes comes off as though he's tired/jaded and in need of a break. I suspect that he's also seen the downsides of having a fanbase with an obsessive dedicated element.
It must be hard. If he stops and talk to fans all the time he'll come across nutty ones, ones who might cry or scream or shove mobile phones in his face and try to manhandle him. (the stuff in the interview about trying to deal with both fans and his security while getting into and out of cars is interesting). If he stops being nice to fans because of that, he'll labelled as thinking he's above them all or not caring or having let fame go to his head.
And he might have let fame go to his head. I think it must be very hard not to, TBH; I think being surrounded by people who enable and say yes to you at all turns, and have the money and power to basically do anything you want, must be very corrupting.
Having said all that 
, we also don't know exactly how that interview went, what other things they talked about that didn't end up in the published version, or what kind of questions and conversational paths the journalist may have used to elicit certain statements and responses.
Benedict has objected to being taken out of context at least once before (in the Guardian, about Julian Assange or a related privacy issue, I think). I'd put money on that kind of thing happening all the time.