I would look at it from the other way round. Rather than think of jobs that are designed around being at home, think about what skills and qualifications you have, your own interests and abilities, facilities you have to hand (storage for stock?, car access, phone, location - city centre based or out in the sticks - all affects type of work). Is this a stop gap before kdis get to school or hopefully a start to a new career opportunity?
What are you good at? team work or on your own, great on the phone or better working via internet and on paper, or in person etc etc. How "brave" are you feeling? would you be ok setting up your own business from scratch eg - a reseller working our of ebay with your own website linked and find your own suppliers.. or would you feel more comfortable working without the isolation - eg. something like Bodyshop party organiser.. What do you hate/are you limitations. Sounds obvious but worth doing. Also - how much time have you honestly got to do this every week? Are you prepared to sit up night after night answering emails, calls, wrapping up parcels or going out to stranger?s houses to run shopping parties etc? Do you have flexible hours or would it be better if it were fixed time slots with definite beginning and ending times to fit in with your homelife needs?
Put it all on paper and ask someone who knows you well enough to be honest with you and see what they think. Start with what you have already and you are more likely to be successful and realistic.
Both my husband and I work from home and are self employed, running a couple of businesses between us. It is not easy and some obvious and some less obvious disadvantages as well as advantages. My advice to you would be to not rush into anything at all but to take time to consider all options.