I work full time and have done since ds was 5 months old. He's now nearly 5, and will be going to full-time school in September.
He was in a day nursery for 2 years, and it was great while he was a baby / toddler, but I got disillusioned with it when he came out of the baby / toddler environment, and ended up taking him out of there - and I put him with a childminder - who is absolutely fantastic.
She now does drop off and pick up at his school, so that is fairless uncomplicated.
We had lots of sleep problems with him when he was 3, and that was really difficult in terms of trying to do my job properly when I'd had very little sleep, but we've managed ok when he's been ill - my dh's job is a lot more flexible than mine (I'm a teacher) - so he tends to do more of the 1 off unavoidable care.
I decided I'd go back full-time when pg, but also swore that seeing as I was doing that, I didn't want to spend valuable family time doing the housework - so we have a cleaner to do that, and what's left, dh and I split totally equally.
I'm now pg with dc2, and although I'm taking a longer maternity leave this time (we're more financially secure than when ds was born), I'm going back to work full-time after my maternity leave this time too.
I really love my job, which makes live a lot easier - I can imagine that it'd be more difficult if I didn't!