I have 4 kids who are 5.5 years apart. I had to go back to work (part-time) when my youngest was 5 months old. When he was 2 I started a full time degree course, as well as continuing to work 16 hours a week. When he was 6 I was working school hours at a school plus evenings in a call centre. When he was 7 I went back to work full time.
The very worst time was when they all got chickenpox over the Xmas holidays one at a time, just 3 weeks after i'd started the new job, and I had to take time off to look after them. Otherwise we've been lucky and we've covered the odd day sick between us with annual leave.
My DH works permanent nights, so we worked around the children, and FIL retired just before I started uni and was available to step into the breach with playgroup pick ups and having odd children for odd afternoons. DH and I hardly saw eachother- we usually passed on the stairs at 7.30 pm as I came in and he went out!
It was hard work, and I don't think we'd have managed without FIL if I'm honest.
As for a life, me and DH have tried to have a week away every year without the kids since the youngest was 2, which is time to remember why we got married (we haven't been able to this year and it feels like we are falling apart at the seams). I went back to am dram and dancing around the time I went back to full time work. Sometimes I wish i'd had a bit more time for them when they were little but they've all turned out just fine and don't hold it against us.