I am finding that being in a department that I've been in for a long time, and feeling underutilised and bored, it has affected my confidence and self-esteem negatively, and being turned down for another job earlier in the year really knocked me back. However, I did get another interview last week, and while I still haven't heard back, there were a couple of comments the interviewers made that made me think, I probably sell myself short, as there was one thing I mentioned as a passing comment which clearly impressed them, and they asked for more details. So even if I don't get this one, that's a useful thing to remember for the next one.
Also a couple of years ago, I went for another job, which I was offered but for a number of reasons, I really wasn't keen on. The recruitment agent was really trying to encourage me (because of course, he makes commission on me accepting), and I said, I wouldn't take the job for a salary which was about 25% more than I was earning at that point, thinking it would price me out of the running. It was quite a shock to me that they took this seriously and negotiated with their HR department, at which point I said I was really sorry, it wasn't just about the money. But again, it taught me that others might well value me more than I value myself.
So, work on your CV, work out what your current goals are, what you need to do to achieve them, what your transferrable skills are that can get you there, and get out there applying! If you don't get any interviews, find someone to review your CV - does it really present what you've got to offer, in a way that the recruiters for the job you're going for will be able to match to their requirements? Are you lacking skills or experience that you might be able to improve by taking a course or doing some job-shadowing in another department? And if you get interviews, but don't get past that, ask for feedback. Even if you don't get a job, every interview is practice, and I think most people come out of interviews thinking, "oh, I should have answered that one better, and why didn't I mention..." So listen to yourself, and make sure next time you do answer that sort of question better and mention whatever it was you left out - prepare some stock answers for typical interview questions, and be ready to refine them. I particularly need to work on "What's your biggest mistake?" because I was sat in my last interview with my mind filled up with, "Don't mention, 'believing I could trust my current manager to have my best interests in mind', too negative for an interview, what was my prepared example, can't remember anything!" And I ended up giving an example from about 14 years ago, but it was a safer answer.
I quite like John Lees' book on CVs, as it gives examples of different ways of presenting CVs according to whether you're going for promotion, changing sector, returning to work, all sorts. He's also done more than one book on interviews, and I've found the one about top answers to tough questions helpful, too. But there are loads of resources out there, free and paid for, and other people would recommend other ones. There may also be stuff available from your current employer - mine is currently really pushing personal development and so on, so there are some useful resources online, and some free courses to develop your skills - so make the most of what's available free.
(I also realise that I am writing this post as a displacement activity from some of my own career-related stuff which I told myself I'd complete this evening. Ahem.)