What are you passionate about?
Working from home is pants if you don't love what you're doing and believe in it because the motivation is the toughest part for most.
Having said that, it's the best if you love being productive, independent and free to follow your path.
There are many multi-level marketing opportunities that will come your way but beware, to be successful (and you can be very successful) you've got to be REALLY driven - it wasn't for me and cost me a lot of money in buying sample products, attending trainings etc. All valuable learnings but be clear about what motivates you.
I did some careers coaching which helped me see what I provided for people (my skill set which is transparent to me!), what I need from people (to fuel my fire and keep me feeling 'loved and appreciated') and what environment I need to work in.
Then there are franchises which come in so many shapes or sizes. They generally need a bigger investment to get set up, but with the right support are potentially bigger businesses.
Working for yourself, you'll almost certainly have to network and meet people, there are lots of networking and business clubs now in every town which can be lots of fun ...and also deadly boring. Cheesy, valuable, rewarding, expensive, lots of different formats and different times of day!
I think you need to start by looking at what/who/where you'd like to work.
I can think of a couple of great coaches I can recommend who might be able to help you, depends whether you've got finance/time to spend investigating!
It'll feel exciting and scary all at the same time!
Hope this helps!
Good luck