I haven't seen a thread on this. Hannah Barnes has written a very good article about the evidence on the harm caused by cross-sex hormones.
https://www.newstatesman.com/politics/health/2025/05/exclusive-why-wes-streeting-changed-his-mind-on-cross-sex-hormones
Archive link: https://archive.is/dRF4t
It's really worrying (though not surprising) to see just how harmful these hormones are:
"Research showed trans women (“natal males”) have a <a class="break-all" href="https://archive.is/o/dRF4t/pmc.ncbi.nlm.nih.gov/articles/PMC6636681/" rel="nofollow" target="_blank">substantially higher risk of ischemic stroke, venous thromboembolism (VTE) – which includes deep vein thrombosis and pulmonary embolism – and heart attacks. After eight years of oestrogen use, trans women had a risk of VTE nearly 17 times higher than other biological males, and 13.7 times than biological women. Studies have also suggested that females who take testosterone, have an increased risk of heart attacks."