I can't find much information about the loss, just a lot about Manuel's initial wins. One thing is for sure though, mixed-sex boxing is happening beyond this Olympic scandal and I'm horrified.
https://sports.yahoo.com/transgender-boxer-patricio-manuel-disappointed-123746108.html?guccounter=1
'Patricio Manuel remained defiant after he suffered the first loss of his career last week. The first out transgender boxer in U.S. history was knocked out by Joshua Bryan Reyes 21 seconds into a bout in Indio, Calif., on April 4. Despite the quick exit, Manuel took to social media to assure fans he was not going to hide or step away from the ring.'
'Manuel was a five-time U.S. national champion in the amateur women’s division. When a shoulder injury forced his withdrawal from the women’s boxing trials for the 2012 Olympics, Manuel took the opportunity to embrace his gender identity.'