FDA puts warning on puberty blockers after children experience serious side effects

[ScreechingEchoChamber]

publications.aap.org/aapnews/news/20636/Risk-of-pseudotumor-cerebri-added-to-labeling-for

'The Food and Drug Administration (FDA) has added a warning about the risk of pseudotumor cerebri (idiopathic intracranial hypertension) to the labeling for gonadotropin-releasing hormone (GnRH) agonists that are approved for the treatment of central precocious puberty in pediatric patients. These products include Lupron Depot-Ped (leuprolide acetate), Fensolvi (leuprolide acetate), Synarel (nafarelin), Supprelin LA (histrelin) and Triptodur (triptorelin).'

The children involved were mostly receiving blockers because of precocious puberty, with one taking them for 'transgender care'.

Meanwhile, Rachel Levine says this:

Biden Assistant Secretary for Health Rachel Levine: We need to “empower” kids to go on puberty blockers and get sex reassignment surgery.

t.co/CRPRaFYtzK

Just looked at the symptoms of intracranial hypertension. Bloody awful.

It's absolutely awful.
I also think mainstream media not reporting on this sort of thing allows it to continue.
This is very concerning.
Poor kids.

It’s not surprising.

Yes, they should put a warning on the drugs but this doesn't seem like a highly common, dangerous or untreatable side-effect as far as most medication is concerned, nor a strong enough reason for people not to take them in itself.

My DS has IIH, it's absolutely bloody awful and has turned our lives upside down. It's incredibly rare in children and the symptoms are insidious, it slowly creeps up and before you know it you're in a full blown crisis with his sight having been permanently impaired. About 60 kids a year are diagnosed in the UK, it is challenging to treat (we're in year 2 of treatment and now looking at surgical options) and it has had serious implications for his schooling and social life.

So sorry, that sounds awful 😞

Levine is dreadful. Levine encapsulates everything that is wrong about the Democrats unthinking devotion to this nonsense. Which will be their undoing.
And I won't use Levine's pronouns.

Rachel Levine is a woman. You can tell this by her pronouns, and because she was named one of USA today's women of the year for 2022.

Clearly Levine has been a woman her whole life. Women born in the 50s had rich opportunities for illustrious medical and military careers.

Yay for women.

The children were all girls aged 5-12, so mostly not even close to puberty even.
Why take the risk of giving small children these untested drugs?
I don’t understand how it’s legal to prescribe drugs for children that are off label and untested.

The children were all girls aged 5-12, so mostly not even close to puberty even. Why take the risk of giving small children these untested drugs?

The report says that for most of the adverse effect cases reported, they were being administered for precocious puberty, which is not an off-label use (afaik).

The thing that upsets me most about "puberty blockers" is that girls and women who had been given them for precocious puberty have been fighting for years to highlight the awful side effects.

Girls in their teens losing teeth and having their jaw bones crumble, women whose spines are disintegrating, serious mental health problems. The problems have been known about for decades and yet these hideous drugs are spoken about as if they're magic pills.

Gnrh analogues are still off label for treating precocious puberty. It's one of the reasons that the girls and women experiencing side effects are having such a hard time getting redress.

I believe the only approved use is for treating prostate cancer and that has only been since 2018.

Long overdue but will be dismissed by all those determined to pursue their goal of transitioning vulnerable children.

Wondering if anyone knows the answer to this as I have no medical background but 'logic' is causing me confusion.

As far as I can find the only studies on effects of GnRHa's on children have been following use to stop precocious puberty.

The ones I've found state that bone density in girls is reduced while taking treatment but resolves once treatment ends and natural hormone levels return.

So.....

If a girl takes GnRHa's, bone density reduces but then they go onto testosterone, would they still have the increase in estrogen necessary to correct the reduced bone density?

If a girl takes GnRHa's, bone density reduces but then they go onto testosterone, would they still have the increase in estrogen necessary to correct the reduced bone density?

It appears not necessarily. Previous thread here:

www.mumsnet.com/talk/womens_rights/4235821-Puberty-blockers-effects-on-bone-density

From the Will Malone article being discussed there:

Dutch studies show that the accrual of bone density recommences when cross-sex hormones are taken from age 16, and so Z-scores increase (Klink et al 2015; Stoffers et al. 2019). But in many cases the recovery is partial, and the Z-scores do not return to the level registered at the onset of GnRHa.

(Snipped all the surrounding context about total lack of follow-up in general use at the Tavistock).

They still don't know if the early menopause effects of blocking puberty and taking testosterone will cause a significant increase in early-onset dementia in trans-identifying females. Play with the wrong toys as a toddler and end up with no breasts, osteoporosis, heart problems and dementia by middle-age.

I can never get over the drug ads on TV when I'm in the States. The way they rattle off all of the side effects of the drug being promoted, I would expect it desensitizes people to warnings.