Editorial that prompted the letters:
www.thelancet.com/pdfs/journals/lanchi/PIIS2352-4642(21)00139-5.pdf
Richard Armitage also has a published letter in response to the editorial and it's excellent:
The Editorial also states that “puberty blockers reduce suicidality.” However, in the systematic review3 cited in support, only one of the nine included studies involving pubertal suppression during adolescence reported suicidality as an outcome measure, specifically among transgender adults aged 18–36 years. In this cross-sectional survey,4 the 89 participants who wanted and received pubertal suppression were compared with the 3405 who wanted but had not received it. The adjusted odds ratio for lifetime suicide ideation was 0·3 (95% CI 0·2–0·6), and no significant difference was found for lifetime suicide attempts (0·7, 0·4–1·0). The study was limited by its non-probability sample design, unmatched controls, online self-reporting method, and inability to determine causation. As such, it is my opinion that this evidence is insufficient to support the Editorial's statement that removing puberty blockers “is to deny life.”
I believe that the Editorial appears to be agenda-driven, ideological, and highly partisan, and contains numerous claims that misrepresent the evidence cited to support them.
www.thelancet.com/journals/lanchi/article/PIIS2352-4642(21)00192-9/fulltext#%20
I hope the Lancet reconsiders its editorial because the flaws identified are substantial.