The daftest things about her tweets are that:
Her starting tweet does not actually answer the question asked (What is the objective difference btw a male and a female?).
Her second tweet refers the questioner to what she claims is the scientific answer to his query, but is actually a fairly basic guide to Health Care for Transgender Individuals. It has nothing to say about the question asked.
And last but not least, her entire line of argument is irrelevant to the claims being argued about, because we know that only a minute fraction of those who identify as trans present with any difference in sex development (DSD). The vast majority are unequivocal males or females with not a hint of a DSD in their physiological makeup.
They simply do not belong to the extreme outliers that these obfuscators like to drag out in support of the claim that humans are not dymorphic/sex is a spectrum/it's more complicated than biology 101
(IIRC, for instance all those referred to GIDS in the UK suffering from gender dysphoria (GD) were tested for DSDs and in over 5000 children presenting with GD, not one was found to have a DSD.)
So, whether or not there are new discoveries of genes or enzymes that influence the natural sex development in utero or adolescence (which that second doctor then talks about in the thread) is of no interest whatsoever when seeking to debate the question of whether men who identify as trans actually are women and vice versa.